Soft gels select tumorigenic cells

2012 ◽  
Vol 11 (8) ◽  
pp. 662-663 ◽  
Author(s):  
Jae-Won Shin ◽  
Dennis E. Discher
Keyword(s):  
Tumorigenic Cells ◽  
Soft Gels

scholarly journals Peppers: A “Hot” Natural Source for Antitumor Compounds

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1521
Author(s):  
Micael Rodrigues Cunha ◽  
Maurício Temotheo Tavares ◽  
Thais Batista Fernandes ◽  
Roberto Parise-Filho
Keyword(s):  
Cell Death ◽  
Cellular Responses ◽  
Biological Applications ◽  
Traditional Use ◽  
Cytotoxic Effects ◽  
Antiproliferative Effects ◽  
Naturally Occurring ◽  
Antitumor Compounds ◽  
Tumorigenic Cells ◽  
Ancient Civilizations

Piper, Capsicum, and Pimenta are the main genera of peppers consumed worldwide. The traditional use of peppers by either ancient civilizations or modern societies has raised interest in their biological applications, including cytotoxic and antiproliferative effects. Cellular responses upon treatment with isolated pepper-derived compounds involve mechanisms of cell death, especially through proapoptotic stimuli in tumorigenic cells. In this review, we highlight naturally occurring secondary metabolites of peppers with cytotoxic effects on cancer cell lines. Available mechanisms of cell death, as well as the development of analogues, are also discussed.

scholarly journals Author Correction: Soft fibrin gels promote selection and growth of tumorigenic cells

2021 ◽  
Author(s):  
Jing Liu ◽  
Youhua Tan ◽  
Huafeng Zhang ◽  
Yi Zhang ◽  
Pingwei Xu ◽  
...  
Keyword(s):  
Fibrin Gels ◽  
Tumorigenic Cells

Quantitation of a 55K cellular protein: similar amount and instability in normal and malignant mouse cells

1982 ◽  
Vol 2 (7) ◽  
pp. 763-771
Author(s):  
P T Mora ◽  
K Chandrasekaran ◽  
J C Hoffman ◽  
V W McFarland
Keyword(s):  
Half Life ◽  
Simian Virus 40 ◽  
Simian Virus ◽  
Cellular Protein ◽  
T Antigen ◽  
Similar Amount ◽  
Parent Cell ◽  
Primary Cells ◽  
Quantitative Expression ◽  
Tumorigenic Cells

Quantitative expression of a specific 55,000 (55K)-molecular-weight cellular protein was studied in two groups of mouse embryo fibroblast (clonal) cells originating from two parent clones, one of which possessed high tumorigenicity and the other of which possessed very low tumorigenicity. From the clone with low tumorigenicity, tumor lines and clones were obtained by selecting rare spontaneously transformed highly tumorigenic (mutant) cells. Cells were labeled during exponential growth for 3 h at 37 degrees C, with [35S]methionine, and the cellular 55K protein was immunoprecipitated with a monoclonal antibody and quantitated. There were low and approximately equal amounts of 55K protein in cells (clones) with both low and high tumorigenicity from both groups of cells, and there was no correlation at all between quantitative expression of 55K protein and of cellular tumorigenicity. There was approximately 10- to 20-fold more 55K protein in all simian virus 40-transformed T antigen-positive derivative clones, as shown previously. The T antigen-negative revertant tumor lines and clones obtained by an immunological in vivo selection method had low amounts of 55K protein, similar to the parent cell before simian virus 40 transformation. In all of the T antigen-negative cells, including the highly tumorigenic cells, degradation (turnover?) of the 55K protein was rapid, and a half-life of 15 to 60 min was estimated from pulse-chase experiments. In all of the T antigen-positive cells the 55K protein was stable (half-life greater than 10 h). In primary cells established from the tumors induced by highly tumorigenic cells there was a very low or no detectable amount of the 55K protein. This is in contrast to the primary cells obtained from early murine embryos in which we have reported high amounts of (stable) 55K proteins.

scholarly journals Formation of Spatially and Geometrically Controlled Three-Dimensional Tissues in Soft Gels by Sacrificial Micromolding

2015 ◽  
Vol 21 (6) ◽  
pp. 541-547 ◽  
Author(s):  
Alec Cerchiari ◽  
James C. Garbe ◽  
Michael E. Todhunter ◽  
Noel Y. Jee ◽  
James R. Pinney ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Soft Gels

scholarly journals THE MECHANISM OF THE INFLAMMATORY PROCESS

1928 ◽  
Vol 11 (6) ◽  
pp. 743-756 ◽  
Author(s):  
Harold A. Abramson
Keyword(s):  
Magnetic Force ◽  
Marked Change ◽  
Polymorphonuclear Leucocyte ◽  
Red Cells ◽  
Fibrin Gels ◽  
Gelatin Gels ◽  
Order Of Magnitude ◽  
And Migration ◽  
Soft Gels ◽  
Mechanical Nature

1. Quartz particles and certain other particles move cataphoretically in certain soft gelatin gels, with the same velocity as in the sol. The speed is a function of the true viscosity of the sol or gel, and it is See PDF for Structure apparently not altered in these soft gels by the presence of gel structure. It is proportional to the applied difference of potential. 2. This finding is compatible with the fact that certain sols undergo gelation with no increase of the true viscosity although a marked change in the apparent viscosity takes place. 3. Red cells in soft gelatin-serum gels show a distinct difference in behavior. They migrate through the sol or gel with a speed that is about twice as great as the leucocytes and quartz particles, which latter particles migrate with the same velocity. This ratio has been found to hold for serum and plasma. The absolute velocities are comparatively slightly decreased by the presence of the gel. 4. In more concentrated or stiffer gels, leucocytes, red cells and quartz particles all move at first with the same velocity. By producing mechanical softening of these gels (shearing from cataphoretic movement of the micells within the cell) the red cells presently resume their previous property of independent migration through the gel. 5. The movements of particles in gelatin gels produced by a magnetic force or the force of gravity are of a different nature than those movements produced by cataphoresis. 6. The mechanical nature of obstruction to the cataphoretic migration of leucocytes and red cells in fibrin gels is briefly described. 7. The correlation of cataphoresis of microscopic particles in gels with the order of magnitude and nature of the potential differences in the capillary wall, lends additional evidence to the theory that polymorphonuclear leucocyte emigration and migration are dependent upon these potential differences.

Detection of Tumorigenic Cells in Friend Virus-Infected Mice: An In Vivo Methodological Investigation2, 3

1981 ◽  
Vol 66 (6) ◽  
pp. 1121-1127 ◽  
Author(s):  
Françoise Moreau-Gachelin ◽  
Françoise Wendling ◽  
Paule Bucau-Varlet ◽  
Martine Charon ◽  
Pierre Tambourin
Keyword(s):  
Friend Virus ◽  
Tumorigenic Cells
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