PML-RARA–targeted DNA vaccine induces protective immunity in a mouse model of leukemia

10.1038/nm949 ◽  
2003 ◽  
Vol 9 (11) ◽  
pp. 1413-1417 ◽  
Author(s):  
Rose Ann Padua ◽  
Jerome Larghero ◽  
Marie Robin ◽  
Carol le Pogam ◽  
Marie-Helene Schlageter ◽  
...  
Keyword(s):  
Mouse Model ◽  
Dna Vaccine ◽  
Protective Immunity

scholarly journals Enhanced Prophylactic and Therapeutic Effects of Polylysine-Modified Ara h 2 DNA Vaccine in a Mouse Model of Peanut Allergy

2016 ◽  
Vol 171 (3-4) ◽  
pp. 241-250 ◽  
Author(s):  
Zhenlai Zhu ◽  
Jinlei Yu ◽  
Yuan Niu ◽  
Shuhong Sun ◽  
Yufeng Liu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Dna Vaccine ◽  
Peanut Allergy ◽  
Therapeutic Effects ◽  
Ara H 2

Development and Evaluation of a DNA Vaccine Based on Helicobacter pylori urease B: Failure to Prevent Experimental Infection in the Mouse Model

Helicobacter ◽  
2006 ◽  
Vol 11 (6) ◽  
pp. 517-522 ◽  
Author(s):  
Livania Zavala-Spinetti ◽  
Mary B. Breslin ◽  
Hernán Correa ◽  
Rodolfo E. Bégué
Keyword(s):  
Helicobacter Pylori ◽  
Mouse Model ◽  
Dna Vaccine ◽  
Experimental Infection

Evaluation of DNA vaccine encoding BCSP31 surface protein of Brucella abortus for protective immunity

2018 ◽  
Vol 125 ◽  
pp. 514-520 ◽  
Author(s):  
Waqar Imtiaz ◽  
Ahrar Khan ◽  
Shafia Tehseen Gul ◽  
Muhammad Saqib ◽  
Muhammad Kashif Saleemi ◽  
...  
Keyword(s):  
Dna Vaccine ◽  
Brucella Abortus ◽  
Protective Immunity ◽  
Surface Protein

scholarly journals Intranasal Delivery of Cationic PLGA Nano/Microparticles- Loaded FMDV DNA Vaccine Encoding IL-6 Elicited Protective Immunity against FMDV Challenge

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e27605 ◽  
Author(s):  
Gang Wang ◽  
Li Pan ◽  
Yongguang Zhang ◽  
Yonglu Wang ◽  
Zhongwang Zhang ◽  
...  
Keyword(s):  
Dna Vaccine ◽  
Protective Immunity ◽  
Intranasal Delivery

scholarly journals Evaluation of Protection Afforded by Brucella abortus and Brucella melitensis Unmarked Deletion Mutants Exhibiting Different Rates of Clearance in BALB/c Mice

2006 ◽  
Vol 74 (7) ◽  
pp. 4048-4057 ◽  
Author(s):  
M. M. Kahl-McDonagh ◽  
T. A. Ficht
Keyword(s):  
Mouse Model ◽  
Brucella Abortus ◽  
Protective Immunity ◽  
Brucella Melitensis ◽  
Deletion Mutants ◽  
Heterologous Challenge ◽  
Current Vaccine ◽  
Protection Against Infection ◽  
Ideal Vaccine

ABSTRACT Research for novel Brucella vaccines has focused upon the development of live vaccine strains, which have proven more efficacious than killed or subunit vaccines. In an effort to develop improved vaccines, signature-tagged mutant banks were screened to identify mutants attenuated for survival. Mutants selected from these screens exhibited various degrees of attenuation characterized by the rate of clearance, ranging from a failure to grow in macrophages after 24 h of infection to a failure to persist in the mouse model beyond 8 weeks. Ideal vaccine candidates should be safe to the host, while evoking protective immunity. In the present work, we constructed unmarked deletion mutants of three gene candidates, manBA, virB2, and asp24, in both Brucella abortus and Brucella melitensis. The Δasp24 mutants, which persist for extended periods in vivo, are superior to current vaccine strains and to other deletion strains tested in the mouse model against homologous challenge infection after 12, 16, and 20 weeks postvaccination. The Δasp24 mutants also display superior protection compared to ΔmanBA and ΔvirB2 mutants against heterologous challenge in mice. From this study, a direct association between protection against infection and cytokine response was not apparent between all vaccine groups and, therefore, correlates of protective immunity will need to be considered further. A distinct correlation between persistence of the vaccine strain and protection against infection was corroborated.

scholarly journals Improving the potency of DNA vaccine encoding HIV-1 Nef antigen using two endogenous adjuvants in mouse model

2017 ◽  
Vol 118 (09) ◽  
pp. 564-569 ◽  
Author(s):  
B. S. Jafarzade ◽  
S. M. Sadat ◽  
R. Yaghobi ◽  
A. Bolhassani
Keyword(s):  
Mouse Model ◽  
Dna Vaccine ◽  
Hiv 1
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