scholarly journals Noninvasive in vivo imaging of pancreatic islet cell biology

2008 ◽  
Vol 14 (5) ◽  
pp. 574-578 ◽  
Author(s):  
Stephan Speier ◽  
Daniel Nyqvist ◽  
Over Cabrera ◽  
Jia Yu ◽  
R Damaris Molano ◽  
...  
Keyword(s):  
Pancreatic Islet ◽  
In Vivo Imaging ◽  
Cell Biology ◽  
Islet Cell ◽  
Pancreatic Islet Cell

scholarly journals Immune Rejection after Pancreatic Islet Cell Transplantation: In Vivo Dual Contrast-enhanced MR Imaging in a Mouse Model

Radiology ◽  
2013 ◽  
Vol 266 (3) ◽  
pp. 822-830 ◽  
Author(s):  
Ping Wang ◽  
Christian Schuetz ◽  
Alana Ross ◽  
Guangping Dai ◽  
James F. Markmann ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Mouse Model ◽  
Cell Transplantation ◽  
Pancreatic Islet ◽  
Islet Cell ◽  
Immune Rejection ◽  
Islet Cell Transplantation ◽  
Pancreatic Islet Cell ◽  
Contrast Enhanced

Pancreatic islet cell biology after treatment with oxygenated perfluorocarbons in culture

2004 ◽  
Vol 112 (S 1) ◽  
Author(s):  
H Bergert ◽  
KP Knoch ◽  
R Meisterfeld ◽  
HD Saeger ◽  
M Solimena
Keyword(s):  
Pancreatic Islet ◽  
Cell Biology ◽  
Islet Cell ◽  
Pancreatic Islet Cell

scholarly journals Recent progress in pancreatic islet cell therapy

2021 ◽  
Vol 41 (1) ◽  
Author(s):  
Erinn Zixuan Sim ◽  
Nobuaki Shiraki ◽  
Shoen Kume
Keyword(s):  
Stem Cells ◽  
Pancreatic Islet ◽  
Islet Cell ◽  
Recent Progress ◽  
Disease Modeling ◽  
Islet Cells ◽  
Pancreatic Islet Cells ◽  
Pancreatic Islet Cell

AbstractHuman pluripotent stem cells (PSCs), including human embryonic stem cells and induced pluripotent stem cells, are promising cell sources in regenerating pancreatic islets through in vitro directed differentiation. Recent progress in this research field has made it possible to generate glucose-responsive pancreatic islet cells from PSCs. Single-cell RNA sequencing techniques have been applied to analyze PSC-derived endocrine beta-cells, which are then compared with human islets. This has led to the identification of novel signaling pathways and molecules involved in lineage commitment during pancreatic differentiation and maturation processes. Single-cell transcriptomics are also used to construct a detailed map of in vivo endocrine differentiation of developing mouse embryos to study pancreatic islet development. Mimicking those occurring in vivo, it was reported that differentiating PSCs can generate similar islet cell structures, while metabolomics analysis highlighted key components involved in PSC-derived pancreatic islet cell function, providing information for the improvement of in vitro pancreatic maturation procedures. In addition, cell transplantation into diabetic animal models, together with the cell delivery system, is studied to ensure the therapeutic potentials of PSC-derived pancreatic islet cells. Combined with gene-editing technology, the engineered mutation-corrected PSC lines originated from diabetes patients could be differentiated into functional pancreatic islet cells, suggesting possible autologous cell therapy in the future. These PSC-derived pancreatic islet cells are a potential tool for studies of disease modeling and drug testing. Herein, we outlined the directed differentiation procedures of PSC-derived pancreatic islet cells, novel findings through transcriptome and metabolome studies, and recent progress in disease modeling.

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