Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system

2007 ◽  
Vol 13 (12) ◽  
pp. 1483-1489 ◽  
Author(s):  
Manuel A Friese ◽  
Matthew J Craner ◽  
Ruth Etzensperger ◽  
Sandra Vergo ◽  
John A Wemmie ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Ion Channel ◽  
Axonal Degeneration ◽  
Autoimmune Inflammation ◽  
The Central Nervous System

scholarly journals Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System

Immunity ◽  
2015 ◽  
Vol 43 (6) ◽  
pp. 1174-1185 ◽  
Author(s):  
Matteo M. Guerrini ◽  
Kazuo Okamoto ◽  
Noriko Komatsu ◽  
Shinichiro Sawa ◽  
Lynett Danks ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Autoimmune Inflammation ◽  
The Central Nervous System ◽  
Family Cytokine

scholarly journals IL-9 is important for T-cell activation and differentiation in autoimmune inflammation of the central nervous system

2011 ◽  
Vol 41 (8) ◽  
pp. 2197-2206 ◽  
Author(s):  
Hongmei Li ◽  
Bardia Nourbakhsh ◽  
Melissa Cullimore ◽  
Guang-Xian Zhang ◽  
Abdolmohamad Rostami
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Autoimmune Inflammation ◽  
The Central Nervous System

Genomic scale profiling of autoimmune inflammation in the central nervous system: the nervous response to inflammation

2002 ◽  
Vol 133 (1-2) ◽  
pp. 95-107 ◽  
Author(s):  
Ruaidhrı́ J Carmody ◽  
Brendan Hilliard ◽  
Kimberly Maguschak ◽  
Lewis A Chodosh ◽  
Youhai H Chen
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Autoimmune Inflammation ◽  
Genomic Scale ◽  
The Central Nervous System

scholarly journals Death of developing neurons: New insights and implications for connectivity

2013 ◽  
Vol 203 (3) ◽  
pp. 385-393 ◽  
Author(s):  
Martijn P.J. Dekkers ◽  
Vassiliki Nikoletopoulou ◽  
Yves-Alain Barde
Keyword(s):  
Central Nervous System ◽  
Cell Death ◽  
Nervous System ◽  
Growth Factors ◽  
Axonal Degeneration ◽  
Neuronal Development ◽  
Critical Role ◽  
Synaptic Function ◽  
The Central Nervous System ◽  
Developing Neurons

The concept that target tissues determine the survival of neurons has inspired much of the thinking on neuronal development in vertebrates, not least because it is supported by decades of research on nerve growth factor (NGF) in the peripheral nervous system (PNS). Recent discoveries now help to understand why only some developing neurons selectively depend on NGF. They also indicate that the survival of most neurons in the central nervous system (CNS) is not simply regulated by single growth factors like in the PNS. Additionally, components of the cell death machinery have begun to be recognized as regulators of selective axonal degeneration and synaptic function, thus playing a critical role in wiring up the nervous system.

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