A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

2005 ◽  
Vol 11 (5) ◽  
pp. 551-555 ◽  
Author(s):  
Mark H Tuszynski ◽  
Leon Thal ◽  
Mary Pay ◽  
David P Salmon ◽  
Hoi Sang U ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Gene Therapy ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Alzheimer Disease ◽  
Phase 1 ◽  
Nerve Growth ◽  
Factor Gene ◽  
Phase 1 Clinical Trial ◽  
Growth Factor Gene

scholarly journals Nerve Growth Factor Gene Therapy Using Adeno-Associated Viral Vectors Prevents Cardiomyopathy in Type 1 Diabetic Mice

Diabetes ◽  
2011 ◽  
Vol 61 (1) ◽  
pp. 229-240 ◽  
Author(s):  
M. Meloni ◽  
B. Descamps ◽  
A. Caporali ◽  
L. Zentilin ◽  
I. Floris ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Viral Vectors ◽  
Diabetic Mice ◽  
Nerve Growth ◽  
Factor Gene ◽  
Growth Factor Gene

scholarly journals SP, CGRP changes in pyridoxine induced neuropathic dogs with nerve growth factor gene therapy

2016 ◽  
Vol 17 (1) ◽  
Author(s):  
Joo-Yeon Kang ◽  
Dae Young Yoo ◽  
Kwon-Young Lee ◽  
Wooseok Im ◽  
Manho Kim ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Nerve Growth ◽  
Factor Gene ◽  
Growth Factor Gene

scholarly journals Nerve Growth Factor Gene Therapy

2015 ◽  
Vol 72 (10) ◽  
pp. 1139 ◽  
Author(s):  
Mark H. Tuszynski ◽  
Jennifer H. Yang ◽  
David Barba ◽  
Hoi-Sang U ◽  
Roy A. E. Bakay ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Nerve Growth ◽  
Factor Gene ◽  
Growth Factor Gene

Nerve growth factor gene therapy for alzheimer’s disease

2002 ◽  
Vol 19 (1-2) ◽  
pp. 207-207 ◽  
Author(s):  
Mark H. Tuszynski ◽  
Leon Thal ◽  
Hoi-Sang U ◽  
Mary Margaret Pay ◽  
Armin Blesch ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gene Therapy ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Nerve Growth ◽  
Factor Gene ◽  
Growth Factor Gene

Growth factor gene therapy for Alzheimer disease

2002 ◽  
Vol 13 (5) ◽  
pp. 1-5 ◽  
Author(s):  
Mark H. Tuszynski ◽  
Hoi Sang U ◽  
John Alksne ◽  
Roy A. Bakay ◽  
Mary Margaret Pay ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Nervous System ◽  
Growth Factors ◽  
Growth Factor ◽  
Alzheimer Disease ◽  
Neuronal Degeneration ◽  
Significant Advance ◽  
Factor Gene ◽  
Growth Factor Gene ◽  
Effective Manner

The capacity to prevent neuronal degeneration and death during the course of progressive neurological disorders such as Alzheimer disease (AD) would represent a significant advance in therapy. Nervous system growth factors are families of naturally produced proteins that, in animal models, exhibit extensive potency in preventing neuronal death due to a variety of causes, reversing age-related atrophy of neurons, and ameliorating functional deficits. The main challenge in translating growth factor therapy to the clinic has been delivery of growth factors to the brain in sufficient concentrations to influence neuronal function. One means of achieving growth factor delivery to the central nervous system in a highly targeted, effective manner may be gene therapy. In this article the authors summarize the development and implementation of nerve growth factor gene delivery as a potential means of reducing cell loss in AD.

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