scholarly journals Erratum: Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy

2007 ◽  
Vol 13 (12) ◽  
pp. 1521-1521 ◽  
Author(s):  
Sam E Day ◽  
Mikko I Kettunen ◽  
Ferdia A Gallagher ◽  
De-En Hu ◽  
Mathilde Lerche ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Tumor Response ◽  
Response To Treatment ◽  
Resonance Imaging ◽  
Hyperpolarized 13C ◽  
Imaging And Spectroscopy

Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy

2007 ◽  
Vol 13 (11) ◽  
pp. 1382-1387 ◽  
Author(s):  
Sam E Day ◽  
Mikko I Kettunen ◽  
Ferdia A Gallagher ◽  
De-En Hu ◽  
Mathilde Lerche ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Tumor Response ◽  
Response To Treatment ◽  
Resonance Imaging ◽  
Hyperpolarized 13C ◽  
Imaging And Spectroscopy

Diffusion Magnetic Resonance Imaging: A Biomarker for Treatment Response in Oncology

2007 ◽  
Vol 25 (26) ◽  
pp. 4104-4109 ◽  
Author(s):  
Daniel A. Hamstra ◽  
Alnawaz Rehemtulla ◽  
Brian D. Ross
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Treatment Response ◽  
Diffusion Magnetic Resonance Imaging ◽  
Tumor Response ◽  
Surrogate Marker ◽  
Response To Treatment ◽  
Resonance Imaging ◽  
Clinical Protocol ◽  
Complicated Process

Imaging of response to oncology treatments, either on clinical protocol or as part of standard practice, is a complicated process that has evolved during the last 10 years due to the improvement of existing imaging technologies and the introduction of newer modalities. Diffusion magnetic resonance imaging is a technique that measures the mobility of water within tissues and, as such, may function as a surrogate marker for both tissue cellularity and response to treatment that occur earlier than usual measures of tumor response. This review highlights the development of this technique and the state of current clinical understanding of its utility.

Magnetic Resonance Imaging and Spectroscopy: New Noninvasive In Vivo Approaches in Toxicology Research

1993 ◽  
Vol 21 (4) ◽  
pp. 411-425
Author(s):  
Manfred Brauer
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Fatty Infiltration ◽  
Chronic Ethanol ◽  
Ethanol Administration ◽  
Resonance Imaging ◽  
Human Patient ◽  
Hypoxic Injury ◽  
Imaging And Spectroscopy

Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS) give anatomical and biochemical information about a human patient or animal in a non-invasive manner. This unique quality permits the study of toxicological responses of an organ within an intact animal and in a manner in which many fewer animals are needed than by conventional methods of investigation. The use of MRI and MRS in the study of hepatotoxicants, particularly bromobenzene and ethanol, is reviewed. Bromobenzene causes localised hepatic oedema and bioenergetic deterioration; these changes were followed with time by 1H MRI and 31P MRS, respectively. Phosphocholine levels in the liver were found to increase dramatically during bromobenzene-induced damage, possibly related to an intracellular control mechanism in response to tissue damage. The ability of the bromobenzene-challenged liver to metabolise a fructose load was followed by dynamic 31P MRS. Chronic ethanol administration damages the liver. This toxicological process results in the accumulation of fat in the liver, which was followed by fat-selective 1H MRI. When ethanol is no longer administered to the subject, the fatty infiltration subsides, and this process was followed over 16 days in the same animal using fat-selective 1H MRI. Chronic ethanol renders the liver in situ more susceptible to hypoxic injury and less likely to recover afterwards, as shown by 31P MRS.

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