Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent

2001 ◽  
Vol 7 (11) ◽  
pp. 1241-1244 ◽  
Author(s):  
Ming Zhao ◽  
Daniel A. Beauregard ◽  
Louiza Loizou ◽  
Bazbek Davletov ◽  
Kevin M. Brindle
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Resonance Imaging ◽  
Non Invasive ◽  
Targeted Contrast Agent

scholarly journals Chronic Thrombus Detection With In Vivo Magnetic Resonance Imaging and a Fibrin-Targeted Contrast Agent

Circulation ◽  
2005 ◽  
Vol 112 (11) ◽  
pp. 1594-1600 ◽  
Author(s):  
Marc Sirol ◽  
Valentin Fuster ◽  
Juan J. Badimon ◽  
John T. Fallon ◽  
Jean-François Toussaint ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Resonance Imaging ◽  
Targeted Contrast Agent

scholarly journals Magnetic resonance imaging of inflammation with a specific selectin-targeted contrast agent

2005 ◽  
Vol 53 (4) ◽  
pp. 800-807 ◽  
Author(s):  
S�bastien Boutry ◽  
Carmen Burtea ◽  
Sophie Laurent ◽  
G�rard Toubeau ◽  
Luce Vander Elst ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Resonance Imaging ◽  
Targeted Contrast Agent

Magnetic resonance imaging of osteosarcoma using a bis(alendronate)-based bone-targeted contrast agent

2016 ◽  
Vol 84 ◽  
pp. 423-429 ◽  
Author(s):  
Pingju Ge ◽  
Fugeng Sheng ◽  
Yiguang Jin ◽  
Li Tong ◽  
Lina Du ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Resonance Imaging ◽  
Targeted Contrast Agent

scholarly journals Preparation and animal experiment of lymphatic system-targeted contrast agent in magnetic resonance imaging

2011 ◽  
Vol 41 (11) ◽  
pp. 1712-1718
Author(s):  
Wei SHANG ◽  
YuanYong FENG ◽  
Yue SUN ◽  
Tao JIANG ◽  
Jing WU ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Animal Experiment ◽  
Lymphatic System ◽  
Resonance Imaging ◽  
Targeted Contrast Agent

scholarly journals Molecular Magnetic Resonance Imaging of Tumors with a PTPµ Targeted Contrast Agent

2013 ◽  
Vol 6 (3) ◽  
pp. 329-337 ◽  
Author(s):  
Susan M Burden-Gulley ◽  
Zhuxian Zhou ◽  
Sonya E.L. Craig ◽  
Zheng-Rong Lu ◽  
Susann M Brady-Kalnay
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Resonance Imaging ◽  
Targeted Contrast Agent

Molecular Magnetic Resonance Imaging of Deep Vein Thrombosis Using a Fibrin-Targeted Contrast Agent

2009 ◽  
Vol 44 (3) ◽  
pp. 146-150 ◽  
Author(s):  
Marcus Katoh ◽  
Patrick Haage ◽  
Andrea J. Wiethoff ◽  
Rolf W. Günther ◽  
Arno Bücker ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Deep Vein Thrombosis ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Resonance Imaging ◽  
Vein Thrombosis ◽  
Deep Vein ◽  
Targeted Contrast Agent

Abstract 1935: A Magnetic Resonance Imaging Contrast Agent Targeted Towards Activated Platelets Allows In Vivo Detection of Thrombosis and Monitoring of Thrombolysis

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Constantin von zur Muehlen ◽  
Dominik Elverfeldt ◽  
Julia Moeller ◽  
Robin Choudhury ◽  
Christoph Hagemeyer ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Carotid Artery ◽  
Contrast Agent ◽  
Resonance Imaging ◽  
Non Invasive ◽  
Activated Platelets ◽  
Signal Void

Platelets are the key to thrombus formation in atherothrombosis and play a major role in plaque rupture. Non-invasive imaging of activated platelets would be of great clinical interest. Here, we evaluate the ability of a magnetic resonance imaging (MRI) contrast agent consisting of microparticles of iron oxide (MPIO) and a single-chain antibody targeting ligand-induced binding sites (LIBS) on activated GPIIb/IIIa to image carotid artery thrombosis and. Anti-LIBS or control antibody were conjugated to 1μm-sized MPIOs (LIBS-MPIO/control-MPIO). Non-occlusive wall-adherent thrombi were induced in BL/6 mice using 6% ferric chloride. MRI (at 9.4 Tesla) of the carotid artery was performed once before (figure , A) and repeatedly in 12min long sequences after LIBS-MPIO/control-MPIO injection. After 36min, a significant signal void, which is the typical effect of iron oxide-based contrast agents, was observed with LIBS-MPIO (figure , B), but not control-MPIO (P<0.01) and corresponded to LIBS-MPIO binding as confirmed by histology. After thrombolysis, in LIBS-MPIO injected mice the signal void subsided, indicating successful thrombolysis (figure , C). On histology, MPIO-content of thrombus, as well as thrombus size, correlated significantly with LIBS-MPIO-induced signal void (both P<0.01). LIBS-MPIO allows in vivo MRI of activated platelets with excellent contrast properties and monitoring of thrombolytic therapy. This approach represents a novel non-invasive technique allowing rapid detection and quantification of platelet-containing thrombi, such as found on the surface of ruptured atherosclerotic plaques.

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