Role of the Y5 neuropeptide Y receptor in feeding and obesity

1998 ◽  
Vol 4 (6) ◽  
pp. 718-721 ◽  
Author(s):  
Donald J. Marsh ◽  
Gunther Hollopeter ◽  
Kathy E. Kafer ◽  
Richard D. Palmiter
Keyword(s):  
Neuropeptide Y ◽  
Neuropeptide Y Receptor

scholarly journals Role of the Y5 neuropeptide Y receptor in limbic seizures

1999 ◽  
Vol 96 (23) ◽  
pp. 13518-13523 ◽  
Author(s):  
D. J. Marsh ◽  
S. C. Baraban ◽  
G. Hollopeter ◽  
R. D. Palmiter
Keyword(s):  
Neuropeptide Y ◽  
Limbic Seizures ◽  
Neuropeptide Y Receptor

Role of a hydrophobic pocket of the human Y1 neuropeptide Y receptor in ligand binding

1995 ◽  
Vol 112 (2) ◽  
pp. 215-222 ◽  
Author(s):  
Martine Sautel ◽  
Raquel Martinez ◽  
Munoz Miguel ◽  
Manuel C. Peitsch ◽  
Annette G. Beck-Sickinger ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Neuropeptide Y ◽  
Hydrophobic Pocket ◽  
Neuropeptide Y Receptor

The Role of Neuropeptide Y and Peptide YY in the Development of Obesity via Gut-brain Axis

2019 ◽  
Vol 20 (7) ◽  
pp. 750-758 ◽  
Author(s):  
Yi Wu ◽  
Hengxun He ◽  
Zhibin Cheng ◽  
Yueyu Bai ◽  
Xi Ma
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Neuropeptide Y ◽  
Metabolic Diseases ◽  
Peptide Yy ◽  
Vital Role ◽  
Gut Peptides ◽  
Nonalcoholic Fatty Liver ◽  
The Central Nervous System

Obesity is one of the main challenges of public health in the 21st century. Obesity can induce a series of chronic metabolic diseases, such as diabetes, dyslipidemia, hypertension and nonalcoholic fatty liver, which seriously affect human health. Gut-brain axis, the two-direction pathway formed between enteric nervous system and central nervous system, plays a vital role in the occurrence and development of obesity. Gastrointestinal signals are projected through the gut-brain axis to nervous system, and respond to various gastrointestinal stimulation. The central nervous system regulates visceral activity through the gut-brain axis. Brain-gut peptides have important regulatory roles in the gut-brain axis. The brain-gut peptides of the gastrointestinal system and the nervous system regulate the gastrointestinal movement, feeling, secretion, absorption and other complex functions through endocrine, neurosecretion and paracrine to secrete peptides. Both neuropeptide Y and peptide YY belong to the pancreatic polypeptide family and are important brain-gut peptides. Neuropeptide Y and peptide YY have functions that are closely related to appetite regulation and obesity formation. This review describes the role of the gutbrain axis in regulating appetite and maintaining energy balance, and the functions of brain-gut peptides neuropeptide Y and peptide YY in obesity. The relationship between NPY and PYY and the interaction between the NPY-PYY signaling with the gut microbiota are also described in this review.

scholarly journals A possible role of neuropeptide Y, agouti-related protein and leptin receptor isoforms in hypothalamic programming by perinatal feeding in the rat

Diabetologia ◽  
2004 ◽  
Vol 48 (1) ◽  
pp. 140-148 ◽  
Author(s):  
M. L�pez ◽  
L. M. Seoane ◽  
S. Tovar ◽  
M. C. Garc�a ◽  
R. Nogueiras ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Leptin Receptor ◽  
Related Protein ◽  
Receptor Isoforms ◽  
Agouti Related Protein

scholarly journals The Role of Neuropeptide Y in the Nucleus Accumbens

2021 ◽  
Vol 22 (14) ◽  
pp. 7287
Author(s):  
Masaki Tanaka ◽  
Shunji Yamada ◽  
Yoshihisa Watanabe
Keyword(s):  
Nervous System ◽  
Nucleus Accumbens ◽  
Neuropeptide Y ◽  
Emotional Behavior ◽  
Characteristic Functions ◽  
Receptor Subtypes ◽  
Neuroendocrine Mechanisms ◽  
Fear And Anxiety ◽  
The Brain

Neuropeptide Y (NPY), an abundant peptide in the central nervous system, is expressed in neurons of various regions throughout the brain. The physiological and behavioral effects of NPY are mainly mediated through Y1, Y2, and Y5 receptor subtypes, which are expressed in regions regulating food intake, fear and anxiety, learning and memory, depression, and posttraumatic stress. In particular, the nucleus accumbens (NAc) has one of the highest NPY concentrations in the brain. In this review, we summarize the role of NPY in the NAc. NPY is expressed principally in medium-sized aspiny neurons, and numerous NPY immunoreactive fibers are observed in the NAc. Alterations in NPY expression under certain conditions through intra-NAc injections of NPY or receptor agonists/antagonists revealed NPY to be involved in the characteristic functions of the NAc, such as alcohol intake and drug addiction. In addition, control of mesolimbic dopaminergic release via NPY receptors may take part in these functions. NPY in the NAc also participates in fat intake and emotional behavior. Accumbal NPY neurons and fibers may exert physiological and pathophysiological actions partly through neuroendocrine mechanisms and the autonomic nervous system.

Role of Neuropeptide Y and Galanin in High Altitude Induced Anorexia in Rats

2001 ◽  
Vol 4 (4) ◽  
pp. 323-331 ◽  
Author(s):  
S.N. Singh ◽  
P. Vats ◽  
Radhey Shyam ◽  
S. Suri ◽  
M.M.L. Kumria ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
High Altitude
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