Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1998 ◽  
Vol 4 (1) ◽  
pp. 97-100 ◽  
Author(s):  
Leigh Holcomb ◽  
Marcia N. Gordon ◽  
Eileen McGowan ◽  
Xin Yu ◽  
Stan Benkovic ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Presenilin 1 ◽  
Alzheimer Type

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Nature ◽  
1995 ◽  
Vol 373 (6514) ◽  
pp. 523-527 ◽  
Author(s):  
Dora Games ◽  
David Adams ◽  
Ree Alessandrini ◽  
Robin Barbour ◽  
Patricia Borthelette ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Alzheimer Type ◽  
Β Amyloid

scholarly journals Vitamin A Deficiency Exacerbates Gut Microbiota Dysbiosis and Cognitive Deficits in Amyloid Precursor Protein/Presenilin 1 Transgenic Mice

2021 ◽  
Vol 13 ◽  
Author(s):  
Bo-Wen Chen ◽  
Kai-Wen Zhang ◽  
Si-Jia Chen ◽  
Chun Yang ◽  
Peng-Gao Li
Keyword(s):  
Cognitive Function ◽  
Vitamin A ◽  
Gut Microbiota ◽  
Transgenic Mice ◽  
Amyloid Precursor Protein ◽  
Intestinal Microbiota ◽  
Gaba Receptors ◽  
Vitamin A Deficiency ◽  
Precursor Protein ◽  
Presenilin 1

Vitamin A deficiency (VAD) plays an essential role in the pathogenesis of Alzheimer’s disease (AD). However, the specific mechanism by which VAD aggravates cognitive impairment is still unknown. At the intersection of microbiology and neuroscience, the gut-brain axis is undoubtedly contributing to the formation and function of neurological systems, but most of the previous studies have ignored the influence of gut microbiota on the cognitive function in VAD. Therefore, we assessed the effect of VAD on AD pathology and the decline of cognitive function in AD model mice and determined the role played by the intestinal microbiota in the process. Twenty 8-week-old male C57BL/6J amyloid precursor protein/presenilin 1 (APP/PS1) transgenic mice were randomly assigned to either a vitamin A normal (VAN) or VAD diet for 45 weeks. Our results show that VAD aggravated the behavioral learning and memory deficits, reduced the retinol concentration in the liver and the serum, decreased the transcription of vitamin A (VA)-related receptors and VA-related enzymes in the cortex, increased amyloid-β peptides (Aβ40 and Aβ42) in the brain and gut, upregulate the translation of beta-site APP-cleaving enzyme 1 (BACE1) and phosphorylated Tau in the cortex, and downregulate the expression of brain-derived neurotrophic factor (BDNF) and γ-aminobutyric acid (GABA) receptors in the cortex. In addition, VAD altered the composition and functionality of the fecal microbiota as exemplified by a decreased abundance of Lactobacillus and significantly different α- and β-diversity. Of note, the functional metagenomic prediction (PICRUSt analysis) indicated that GABAergic synapse and retinol metabolism decreased remarkably after VAD intervention, which was in line with the decreased expression of GABA receptors and the decreased liver and serum retinol. In summary, the present study provided valuable facts that VAD exacerbated the morphological, histopathological, molecular biological, microbiological, and behavioral impairment in the APP/PS1 transgenic mice, and the intestinal microbiota may play a key mediator role in this mechanism.

Reelin in plaques of β-amyloid precursor protein and presenilin-1 double-transgenic mice

2001 ◽  
Vol 316 (3) ◽  
pp. 145-148 ◽  
Author(s):  
Oliver Wirths ◽  
Gerd Multhaup ◽  
Christian Czech ◽  
Véronique Blanchard ◽  
Günter Tremp ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Presenilin 1 ◽  
Β Amyloid ◽  
Double Transgenic Mice

Central cholinergic functions in human amyloid precursor protein knock-in/presenilin-1 transgenic mice

Neuroscience ◽  
2004 ◽  
Vol 125 (4) ◽  
pp. 1009-1017 ◽  
Author(s):  
J Hartmann ◽  
C Erb ◽  
U Ebert ◽  
K.H Baumann ◽  
A Popp ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Presenilin 1

Nitrosylation of Vesicular Transporters in Brain of Amyloid Precursor Protein/Presenilin 1 Double Transgenic Mice

2016 ◽  
Vol 55 (4) ◽  
pp. 1683-1692 ◽  
Author(s):  
Ying Wang ◽  
Zhu Zhou ◽  
Hua Tan ◽  
Shenghua Zhu ◽  
Yiran Wang ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Presenilin 1 ◽  
Vesicular Transporters ◽  
Double Transgenic Mice

Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes

2001 ◽  
Vol 891 (1-2) ◽  
pp. 42-53 ◽  
Author(s):  
Gary W. Arendash ◽  
David L. King ◽  
Marcia N. Gordon ◽  
Dave Morgan ◽  
Jaime M. Hatcher ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Presenilin 1 ◽  
Age Related ◽  
Behavioral Impairments
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