scholarly journals Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination

2016 ◽  
Vol 22 (12) ◽  
pp. 1456-1464 ◽  
Author(s):  
Jiwon Lee ◽  
Daniel R Boutz ◽  
Veronika Chromikova ◽  
M Gordon Joyce ◽  
Christopher Vollmers ◽  
...  
Keyword(s):  
Young Adults ◽  
Influenza Vaccination ◽  
Seasonal Influenza ◽  
Molecular Level ◽  
Serum Antibody ◽  
Antibody Repertoire ◽  
Seasonal Influenza Vaccination ◽  
Before And After ◽  
Level Analysis

scholarly journals Serology in the 21st century: the molecular-level analysis of the serum antibody repertoire

2015 ◽  
Vol 35 ◽  
pp. 89-97 ◽  
Author(s):  
Yariv Wine ◽  
Andrew P Horton ◽  
Gregory C Ippolito ◽  
George Georgiou
Keyword(s):  
21St Century ◽  
Molecular Level ◽  
Serum Antibody ◽  
Antibody Repertoire ◽  
Level Analysis

scholarly journals Heterotypic Neuraminidase Antibodies Against Different A(H1N1) Strains are Elicited after Seasonal Influenza Vaccination

Vaccines ◽  
2019 ◽  
Vol 7 (1) ◽  
pp. 30 ◽  
Author(s):  
Jose Mendez-Legaza ◽  
Raúl Ortiz de Lejarazu ◽  
Ivan Sanz
Keyword(s):  
Immune Response ◽  
Influenza Vaccination ◽  
Seasonal Influenza ◽  
Geometric Mean ◽  
Age Groups ◽  
Influenza Vaccines ◽  
Serum Samples ◽  
Seasonal Influenza Vaccination ◽  
Before And After ◽  
Original Antigenic Sin

Neuraminidase (NA) content is not standardized in current seasonal influenza vaccines; neither anti-NA antibodies (anti-NA Abs) are measured nor is it well-defined as a correlate of humoral protection. In this work, the presence of NA1 antibodies against classical A(H1N1) and A(H1N1) pdm09 subtypes was studied before and after vaccination with seasonal vaccines containing A/California/07/2009 strain (A(H1N1) pdm09 subtype). By Enzyme-Linked Lectin Assay (ELLA; Consortium for the Standardization of Influenza Seroepidemiology), we analyzed serum samples from two different cohorts (adults and elderly). The presence of anti-NA Abs at titers ≥1/40 against classical A(H1N1) and A(H1N1) pdm09 subtypes were frequently found in both age groups, in 81.3% and 96.3% of adults and elderly, respectively. The higher titers of anti-NA Abs (NAI titers) were detected more frequently against classical A(H1N1) strains according to the expected age when the first flu infection takes place. In this way, an Original Antigenic Sin phenomenon related to NA seems to be part of the immune response against flu. Seasonal-vaccination induced homologous seroconversion against NA of A(H1N1) pdm09 subtype in 52.5% and 55.0%, and increased the Geometric Mean Titers (GMTs) in 70.0% and 78.8% of adults and elderly, respectively. Seasonal vaccination also induced a heterotypic anti-NA Abs response against classical A(H1N1) strains (seroconversion at least in 8.8% and 11.3% of adults and elderly, respectively, and an increase in GMTs of at least 28.0% in both age groups). These anti-NA Abs responses occur even though the seasonal vaccine does not contain a standardized amount of NA. This work demonstrates that seasonal vaccines containing the A(H1N1) pdm09 subtype induce a broad antibody response against NA1, that may be a target for future influenza vaccines. Our study is one of the first to analyze the presence of Abs against NA and the response mediated by NAI titers after seasonal influenza vaccination.

scholarly journals Impact of national influenza vaccination strategy in severe influenza outcomes among the high-risk Portuguese population

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Ausenda Machado ◽  
Irina Kislaya ◽  
Amparo Larrauri ◽  
Carlos Matias Dias ◽  
Baltazar Nunes
Keyword(s):  
High Risk ◽  
Influenza Vaccination ◽  
Seasonal Influenza ◽  
Vaccine Coverage ◽  
Vaccination Strategy ◽  
High Risk Population ◽  
Risk Population ◽  
Seasonal Influenza Vaccination ◽  
Severe Influenza ◽  
The Impact

Abstract Background All aged individuals with a chronic condition and those with 65 and more years are at increased risk of severe influenza post-infection complications. There is limited research on cases averted by the yearly vaccination programs in high-risk individuals. The objective was to estimate the impact of trivalent seasonal influenza vaccination on averted hospitalizations and death among the high-risk population in Portugal. Methods The impact of trivalent seasonal influenza vaccination was estimated using vaccine coverage, vaccine effectiveness and the number of influenza-related hospitalizations and deaths. The number of averted events (NAE), prevented fraction (PF) and number needed to vaccinate (NVN) were estimated for seasons 2014/15 to 2016/17. Results The vaccination strategy averted on average approximately 1833 hospitalizations and 383 deaths per season. Highest NAE was observed in the ≥65 years population (85% of hospitalizations and 95% deaths) and in the 2016/17 season (1957 hospitalizations and 439 deaths). On average, seasonal vaccination prevented 21% of hospitalizations in the population aged 65 and more, and 18.5% in the population with chronic conditions. The vaccination also prevented 29% and 19.5% of deaths in each group of the high-risk population. It would be needed to vaccinate 3360 high-risk individuals, to prevent one hospitalization and 60,471 high-risk individuals to prevent one death. Conclusion The yearly influenza vaccination campaigns had a sustained positive benefit for the high-risk population, reducing hospitalizations and deaths. These results can support public health plans toward increased vaccine coverage in high-risk groups.

scholarly journals Seasonal influenza vaccination coverage and its determinants among nursing homes personnel in western France

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Christelle Elias ◽  
Anna Fournier ◽  
Anca Vasiliu ◽  
Nicolas Beix ◽  
Rémi Demillac ◽  
...  
Keyword(s):  
Nursing Homes ◽  
Influenza Vaccination ◽  
Vaccination Coverage ◽  
Seasonal Influenza ◽  
Seasonal Influenza Vaccination

scholarly journals Support for Seasonal Influenza Vaccination Requirements among US Healthcare Personnel

2012 ◽  
Vol 33 (3) ◽  
pp. 213-221 ◽  
Author(s):  
Jürgen Maurer ◽  
Katharine M. Harris ◽  
Carla L. Black ◽  
Gary L. Euler
Keyword(s):  
Influenza Vaccination ◽  
Seasonal Influenza ◽  
Safety Issue ◽  
Healthcare Personnel ◽  
Sampling Frame ◽  
Staff Support ◽  
Term Care ◽  
Seasonal Influenza Vaccination ◽  
Care Facilities ◽  
Serious Disease

Objective.To measure support for seasonal influenza vaccination requirements among US healthcare personnel (HCP) and its associations with attitudes regarding influenza and influenza vaccination and self-reported coverage by existing vaccination requirements.Design.Between lune 1 and June 30, 2010, we surveyed a sample of US HCP (n = 1,664) recruited using an existing probability-based online research panel of participants representing the US general population as a sampling frame.Setting.General community.Participants.Eligible HCP who (1) reported having worked as medical doctors, health technologists, healthcare support staff, or other health practitioners or who (2) reported having worked in hospitals, ambulatory care facilities, long-term care facilities, or other health-related settings.Methods.We analyzed support for seasonal influenza vaccination requirements for HCP using proportion estimation and multivariable probit models.Results.A total of 57.4% (95% confidence interval, 53.3%–61.5%) of US HCP agreed that HCP should be required to be vaccinated for seasonal influenza. Support for mandatory vaccination was statistically significantly higher among HCP who were subject to employer-based influenza vaccination requirements, who considered influenza to be a serious disease, and who agreed that influenza vaccine was safe and effective.Conclusions.A majority of HCP support influenza vaccination requirements. Moreover, providing HCP with information about the safety of influenza vaccination and communicating that immunization of HCP is a patient safety issue may be important for generating staff support for influenza vaccination requirements.Infect Control Hosp Epidemiol 2012;33(3):213-221

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