scholarly journals Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1

2012 ◽  
Vol 18 (8) ◽  
pp. 1232-1238 ◽  
Author(s):  
Kristin Stock ◽  
Jitender Kumar ◽  
Michael Synowitz ◽  
Stefania Petrosino ◽  
Roberta Imperatore ◽  
...  
Keyword(s):  
Cell Death ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
High Grade ◽  
Induce Cell Death ◽  
Stimulation Of

Abstract 215: Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1.

2013 ◽  
Author(s):  
Michael Synowitz ◽  
Kristin Stock ◽  
Jitender Kumar ◽  
Stefania Petrosino ◽  
Roberta Imperatore ◽  
...  
Keyword(s):  
Cell Death ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
High Grade ◽  
Induce Cell Death ◽  
Stimulation Of

scholarly journals P17.36 * ENDOGENOUS NEURAL PRECURSOR CELLS INDUCE CELL DEATH OF HIGH-GRADE ASTROCYTOMAS AND HAVE A TROPISM TO TUMORS IN THE HUMAN BRAIN

2014 ◽  
Vol 16 (suppl 2) ◽  
pp. ii95-ii95
Author(s):  
R. Glass ◽  
K. Stock ◽  
J. Macas ◽  
H. Kettenmann ◽  
S. Momma ◽  
...  
Keyword(s):  
Cell Death ◽  
Human Brain ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
High Grade ◽  
Induce Cell Death

Human neural precursor cells continue to proliferate and exhibit low cell death after transplantation to the injured rat spinal cord

2009 ◽  
Vol 1278 ◽  
pp. 15-26 ◽  
Author(s):  
Mia Emgård ◽  
Lena Holmberg ◽  
Eva-Britt Samuelsson ◽  
Ben A. Bahr ◽  
Scott Falci ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cell Death ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Rat Spinal Cord

scholarly journals Viral mitochondria-localized inhibitor of apoptosis (UL37 exon 1 protein) does not protect human neural precursor cells from human cytomegalovirus-induced cell death

2012 ◽  
Vol 93 (11) ◽  
pp. 2436-2446 ◽  
Author(s):  
Richard L. Hildreth ◽  
Matthew D. Bullough ◽  
Aiping Zhang ◽  
Hui-Ling Chen ◽  
Philip H. Schwartz ◽  
...  
Keyword(s):  
Cell Death ◽  
Human Cytomegalovirus ◽  
Hcmv Infection ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Inhibitor Of Apoptosis ◽  
Neural Precursor ◽  
Wild Type ◽  
Exon 1 ◽  
Oxygen Tensions

Congenital human cytomegalovirus (HCMV) infection can cause severe brain abnormalities. Apoptotic HCMV-infected brain cells have been detected in a congenitally infected infant. In biologically relevant human neural precursor cells (hNPCs), cultured in physiological oxygen tensions, HCMV infection (m.o.i. of 1 or 3) induced cell death within 3 days post-infection (p.i.) and increased thereafter. Surprisingly, its known anti-apoptotic genes, including the potent UL37 exon 1 protein (pUL37x1) or viral mitochondria-localized inhibitor of apoptosis (vMIA), which protects infected human fibroblasts (HFFs) from apoptosis and from caspase-independent, mitochondrial serine protease-mediated cell death, were expressed by 2 days p.i. Consistent with this finding, an HCMV UL37x1 mutant, BADsubstitutionUL37x1 (BADsubUL37x1) induced cell death in hNPCs (m.o.i. = 1) to level which were indistinguishable from parental virus (BADwild-type)-infected hNPCs. Surprisingly, although BADsubUL37x1 is growth defective in permissive HFFs, it produced infectious progeny in hNPCs with similar kinetics and to levels comparable to BADwild-type-infected hNPCs (m.o.i. = 1). While delayed at a lower multiplicity (m.o.i. = 0.3), the BADsubUL37x1 mutant reached similar levels to revertant within 12 days, in contrast to its phenotype in HFFs. The inability of pUL37x1/vMIA to protect hNPCs from HCMV-induced cell death did not result from impaired trafficking as pUL37x1/vMIA trafficked efficiently to mitochondria in transfected hNPCs and in HCMV-infected hNPCs. These results establish that pUL37x1/vMIA, although protective in permissive HFFs, does not protect HCMV-infected hNPCs from cell death under physiologically relevant oxygen tensions. They further suggest that pUL37x1/vMIA is not essential for HCMV growth in hNPCs and has different cell type-specific roles.

scholarly journals Isoflurane Inhibits Growth but Does Not Cause Cell Death in Hippocampal Neural Precursor Cells Grown in Culture

2009 ◽  
Vol 110 (4) ◽  
pp. 826-833 ◽  
Author(s):  
Jeffrey W. Sall ◽  
Greg Stratmann ◽  
Jason Leong ◽  
William McKleroy ◽  
Daniel Mason ◽  
...  
Keyword(s):  
Cell Death ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor

scholarly journals Impact of lactic acid on cell proliferation and free radical-induced cell death in monolayer cultures of neural precursor cells

2009 ◽  
Vol 103 (6) ◽  
pp. 1214-1223 ◽  
Author(s):  
Kyle J. Lampe ◽  
Rachael M. Namba ◽  
Tyler R. Silverman ◽  
Kimberly B. Bjugstad ◽  
Melissa J. Mahoney
Keyword(s):  
Cell Proliferation ◽  
Cell Death ◽  
Lactic Acid ◽  
Free Radical ◽  
Precursor Cells ◽  
Neural Precursor Cells ◽  
Neural Precursor ◽  
Monolayer Cultures
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