Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results

2011 ◽  
Vol 17 (10) ◽  
pp. 1315-1319 ◽  
Author(s):  
Gooitzen M van Dam ◽  
George Themelis ◽  
Lucia M A Crane ◽  
Niels J Harlaar ◽  
Rick G Pleijhuis ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Fluorescence Imaging ◽  
Folate Receptor ◽  
Specific Fluorescence

A folate receptor-specific activatable probe for near-infrared fluorescence imaging of ovarian cancer

2014 ◽  
Vol 50 (56) ◽  
pp. 7507-7510 ◽  
Author(s):  
Hawon Lee ◽  
Jisu Kim ◽  
Hyunjin Kim ◽  
Youngmi Kim ◽  
Yongdoo Choi
Keyword(s):  
Ovarian Cancer ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Folate Receptor ◽  
Near Infrared Fluorescence ◽  
Background Ratio ◽  
Near Infrared Fluorescence Imaging ◽  
Activatable Probe

A folate receptor-specific activatable probe for in vivo near-infrared fluorescence imaging with a high target-to-background ratio was synthesized.

T-Cell Immunity to the Folate Receptor Alpha Is Prevalent in Women With Breast or Ovarian Cancer

2006 ◽  
Vol 24 (26) ◽  
pp. 4254-4261 ◽  
Author(s):  
Keith L. Knutson ◽  
Christopher J. Krco ◽  
Courtney L. Erskine ◽  
Karin Goodman ◽  
Linda E. Kelemen ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Immune System ◽  
T Cell ◽  
Cancer Patients ◽  
Folate Receptor ◽  
Prediction Algorithm ◽  
Amino Terminus ◽  
Folate Receptor Alpha ◽  
Receptor Alpha ◽  
Healthy Donors

Purpose Studies have demonstrated that the generation of immunity to tumor antigens is associated with improved prognosis for many cancers. A candidate antigen is the folate receptor alpha (FRα), which is overexpressed in breast and ovarian cancers. Our goal in this study was to attain a better understanding of the extent of endogenous FRα immunity. Methods Using a CD4+ T cell epitope prediction algorithm, we predicted promiscuous epitopes of FRα, and tested for immunity in 30 breast (n = 17) or ovarian (n = 13) cancer patients and 18 healthy donors using enzyme-linked immunospot analysis. Results Fourteen peptides were predicted, seven each from the carboxy- and amino-terminus halves of the protein. More than 70% of patients demonstrated immunity to at least one FRα peptide. Patients responded to an average of 3 ± 0.5 peptides, whereas healthy donors responded to 1 ± 0.4 peptides (P = .004). Five peptides were recognized by more than 25% of patients. Responses to three peptides were higher (P < .05) in patients than in healthy donors, suggesting augmented immunity. Compared with healthy individuals, patients developed higher immunity to the amino-terminus half of the receptor (P = .03). There was no difference between each group in the responses to nonspecific (P = .2) and viral stimuli (P = .5). Lastly, patients demonstrated elevated levels of FRα antibodies consistent with a coordinated immune response. Conclusion These findings demonstrate that the FRα is a target of the immune system in breast and ovarian cancer patients. Understanding which antigens are targeted by the immune system may be important for prognosis or immune-based therapies.

Folate receptor: a potential target in ovarian cancer

Pteridines ◽  
2015 ◽  
Vol 26 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Marie Bartouskova ◽  
Bohuslav Melichar ◽  
Beatrice Mohelnikova-Duchonova
Keyword(s):  
Ovarian Cancer ◽  
Anticancer Agents ◽  
Poor Prognosis ◽  
Current Knowledge ◽  
Folate Receptor ◽  
Gynecological Cancer ◽  
Predictive Biomarkers ◽  
Receptor Expression ◽  
Advanced Stage ◽  
Potential Therapeutic Target

AbstractOvarian cancer is the most frequent cause of gynecological cancer-related death. Unfortunately, many patients are diagnosed at an advanced stage and have a poor prognosis. The standard treatment for advanced disease involves maximal cytoreductive surgery and chemotherapy based on platinum compounds and taxanes. Patients presenting at an advanced stage have a higher risk of recurrence. The development of drug resistance currently represents a major obstacle in the systematic treatment and, therefore, the discovery of new anticancer agents and approaches should improve the poor prognosis of these patients. Folate receptor α is overexpressed in epithelial ovarian cancer (EOC), but has limited expression in nonmalignant human tissues. The degree of folate receptor expression corresponds with the stage and grade of the disease. Because of this, folate receptor α seems to be a potential therapeutic target for the treatment of ovarian cancer. Currently, several approaches have been studied to target this protein in ovarian cancer treatment. This review summarizes current knowledge about the potential usage of folate receptors as prognostic and predictive biomarkers as well as their role in the management and targeted therapy of ovarian cancer.

scholarly journals Improved Synthesis Strategy for Peptide Nucleic Acids (PNA) appropriate for Cell-specific Fluorescence Imaging

2012 ◽  
Vol 9 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Rüdiger Pipkorn ◽  
Manfred Wiessler ◽  
Waldemar Waldeck ◽  
Ute Hennrich ◽  
Kiyoshi Nokihara ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Fluorescence Imaging ◽  
Peptide Nucleic Acids ◽  
Specific Fluorescence ◽  
Synthesis Strategy

A Strategy for Specific Fluorescence Imaging of Monoamine Oxidase A in Living Cells

2017 ◽  
Vol 129 (48) ◽  
pp. 15521-15525 ◽  
Author(s):  
Xiaofeng Wu ◽  
Wen Shi ◽  
Xiaohua Li ◽  
Huimin Ma
Keyword(s):  
Monoamine Oxidase ◽  
Fluorescence Imaging ◽  
Living Cells ◽  
Monoamine Oxidase A ◽  
Specific Fluorescence

“Dual Lock-and-Key”-Controlled Nanoprobes for Ultrahigh Specific Fluorescence Imaging in the Second Near-Infrared Window

2018 ◽  
Vol 30 (31) ◽  
pp. 1801140 ◽  
Author(s):  
Yufu Tang ◽  
Yuanyuan Li ◽  
Xiaoming Hu ◽  
Hui Zhao ◽  
Yu Ji ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Near Infrared ◽  
Specific Fluorescence ◽  
Infrared Window

scholarly journals A Molecularly Targeted Intraoperative Near-Infrared Fluorescence Imaging Agent for High-Grade Serous Ovarian Cancer

2020 ◽  
Vol 17 (8) ◽  
pp. 3140-3147 ◽  
Author(s):  
Kimberly Fung ◽  
Sai Kiran Sharma ◽  
Outi Keinänen ◽  
Kara Long Roche ◽  
Jason S. Lewis ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Imaging Agent ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Near Infrared Fluorescence ◽  
Near Infrared Fluorescence Imaging
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