scholarly journals Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

2010 ◽  
Vol 16 (5) ◽  
pp. 535-543 ◽  
Author(s):  
Li Yang ◽  
Tatiana Y Besschetnova ◽  
Craig R Brooks ◽  
Jagesh V Shah ◽  
Joseph V Bonventre
Keyword(s):  
Cell Cycle ◽  
Epithelial Cell ◽  
Cell Cycle Arrest ◽  
Kidney Fibrosis ◽  
Cycle Arrest

scholarly journals MicroRNA‐493 targets STMN‐1 and promotes hypoxia‐induced epithelial cell cycle arrest in G 2 /M and renal fibrosis

2018 ◽  
Vol 33 (2) ◽  
pp. 1565-1577 ◽  
Author(s):  
Ting Liu ◽  
Limin Liu ◽  
Minna Liu ◽  
Rui Du ◽  
Yangjie Dang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Epithelial Cell ◽  
Cell Cycle Arrest ◽  
Renal Fibrosis ◽  
Cycle Arrest

scholarly journals Sonic Hedgehog Opposes Epithelial Cell Cycle Arrest

1999 ◽  
Vol 147 (1) ◽  
pp. 71-76 ◽  
Author(s):  
Hongran Fan ◽  
Paul A. Khavari
Keyword(s):  
Cell Cycle ◽  
Epithelial Cell ◽  
Cell Cycle Arrest ◽  
Sonic Hedgehog ◽  
Growth Arrest ◽  
Epidermal Hyperplasia ◽  
Shh Pathway ◽  
Cycle Arrest ◽  
Pathway Activation

Stratified epithelium displays an equilibrium between proliferation and cell cycle arrest, a balance that is disrupted in basal cell carcinoma (BCC). Sonic hedgehog (Shh) pathway activation appears sufficient to induce BCC, however, the way it does so is unknown. Shh-induced epidermal hyperplasia is accompanied by continued cell proliferation in normally growth arrested suprabasal cells in vivo. Shh-expressing cells fail to exit S and G2/M phases in response to calcium-induced differentiation and also resist exhaustion of replicative growth capacity. In addition, Shh blocks p21CIP1/WAF1-induced growth arrest. These data indicate that Shh promotes neoplasia by opposing normal stimuli for epithelial cell cycle arrest.

Sepsis from Pseudomonas aeruginosa pneumonia decreases intestinal proliferation and induces gut epithelial cell cycle arrest*

2003 ◽  
Vol 31 (6) ◽  
pp. 1630-1637 ◽  
Author(s):  
Craig M. Coopersmith ◽  
Paul E. Stromberg ◽  
Christopher G. Davis ◽  
W. Michael Dunne ◽  
Daniel M. Amiot ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Pseudomonas Aeruginosa ◽  
Epithelial Cell ◽  
Cell Cycle Arrest ◽  
Cycle Arrest ◽  
Intestinal Proliferation

scholarly journals Retinoblastoma protein promotes uterine epithelial cell cycle arrest and necroptosis for embryo invasion

EMBO Reports ◽  
2021 ◽  
Author(s):  
Shun Akaeda ◽  
Yasushi Hirota ◽  
Yamato Fukui ◽  
Shizu Aikawa ◽  
Ryoko Shimizu‐Hirota ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Epithelial Cell ◽  
Cell Cycle Arrest ◽  
Retinoblastoma Protein ◽  
Uterine Epithelial Cell ◽  
Cycle Arrest

scholarly journals Lipocalin-2 abrogates epithelial cell cycle arrest by PPARγ inhibition

2018 ◽  
Vol 98 (11) ◽  
pp. 1408-1422 ◽  
Author(s):  
Michaela Jung ◽  
Bernhard Brüne ◽  
Andreas von Knethen ◽  
Roser Guiteras ◽  
Josep Maria Cruzado ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Epithelial Cell ◽  
Cell Cycle Arrest ◽  
Lipocalin 2 ◽  
Cycle Arrest
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