scholarly journals Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging

2009 ◽  
Vol 15 (10) ◽  
pp. 1219-1223 ◽  
Author(s):  
Benjamin J Vakoc ◽  
Ryan M Lanning ◽  
James A Tyrrell ◽  
Timothy P Padera ◽  
Lisa A Bartlett ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Frequency Domain ◽  
Three Dimensional ◽  
Optical Frequency ◽  
Optical Frequency Domain Imaging

Abstract 11863: Enhanced Adventitial Vasa Vasorum Formation in Patients With Vasospastic Angina -Assessment With Optical Frequency Domain Imaging-

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Kensuke Nishimiya ◽  
Yasuharu Matsumoto ◽  
Jun Takahashi ◽  
Takeshi Kato ◽  
Kazuma Oyama ◽  
...  
Keyword(s):  
Frequency Domain ◽  
Coronary Spasm ◽  
Vasa Vasorum ◽  
Vasospastic Angina ◽  
Optical Frequency ◽  
Cardiovascular Risks ◽  
Optical Frequency Domain Imaging ◽  
Control Subjects ◽  
And Control

Background: We have previously demonstrated that adventitial inflammation, including enhanced formation of adventitial vasa vasorum (VV), is involved in the pathogenesis of coronary spasm in porcine models and that optical frequency domain imaging (OFDI) allows us to visualize adventitial VV in humans in vivo. However, it remains to be elucidated whether adventitial VV is also involved in the coronary hyperconstriction in patients with vasospastic angina (VSA). In this study, we thus examined the extent of VV formation in VSA patients and control subjects by using OFDI. Methods: OFDI image acquisition of the left anterior descending coronary artery (LAD) was performed along the LAD at every 10 mm length after intracoronary administration of isosorbide dinitrate in 21 patients with acetylcholine-induced spasm and 10 control subjects without the spasm. Results: Patient characteristics were comparable between VSA patients and control subjects, including sex, age, cardiovascular risks and medications. OFDI and reconstructed 3D-OFDI images clearly visualized enhanced VV formation in VSA patients as compared with control subjects (Figure). Quantitative analysis showed that VV area was significantly larger in VSA patients than in control subjects (VSA, 0.093±0.006 vs. control, 0.040±0.006 mm 2 , P<0.0001), whereas vessel diameter, wall thickness and coronary lesion types were all comparable between the 2 groups. Conclusions: These results demonstrate for the first time that adventitial VV formation is enhanced at the spastic coronary segment in VSA patients, suggesting the important role of adventitial VV in the pathogenesis of coronary spasm.

Optical Frequency Domain Imaging: In Vivo Volumetric Microscopy Of The Airway Wall And Beyond

2011 ◽  
Author(s):  
Melissa J. Suter ◽  
Milen Shishkov ◽  
Lida P. Hariri ◽  
Matthew B. Applegate ◽  
Guillermo J. Tearney ◽  
...  
Keyword(s):  
Frequency Domain ◽  
Optical Frequency ◽  
Airway Wall ◽  
Optical Frequency Domain Imaging

scholarly journals In Vivo Visualization of Adventitial Vasa Vasorum of the Human Coronary Artery on Optical Frequency Domain Imaging

2014 ◽  
Vol 78 (10) ◽  
pp. 2516-2518 ◽  
Author(s):  
Kensuke Nishimiya ◽  
Yasuharu Matsumoto ◽  
Jun Takahashi ◽  
Hironori Uzuka ◽  
Yuji Odaka ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Frequency Domain ◽  
Vasa Vasorum ◽  
Optical Frequency ◽  
Human Coronary Artery ◽  
Optical Frequency Domain Imaging
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