Sustained exposure to bacterial antigen induces interferon-γ-dependent T cell receptor ζ down-regulation and impaired T cell function

10.1038/ni975 ◽  
2003 ◽  
Vol 4 (10) ◽  
pp. 957-964 ◽  
Author(s):  
Noemí Bronstein-Sitton ◽  
Leonor Cohen-Daniel ◽  
Ilan Vaknin ◽  
Analía V Ezernitchi ◽  
Benny Leshem ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Function ◽  
Cell Receptor ◽  
Interferon Γ ◽  
Bacterial Antigen ◽  
Down Regulation ◽  
T Cell Function

scholarly journals Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function

2012 ◽  
Vol 109 (5) ◽  
pp. 1625-1630 ◽  
Author(s):  
A. Zanin-Zhorov ◽  
J. Lin ◽  
J. Scher ◽  
S. Kumari ◽  
D. Blair ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Regulatory T Cell ◽  
Cell Function ◽  
Cell Receptor ◽  
Scaffold Protein ◽  
T Cell Function

Loss of T-cell receptor-CD3ζ and T-cell function in tumor-infiltrating lymphocytes but not in tumor-associated lymphocytes in ovarian carcinoma

Surgery ◽  
2001 ◽  
Vol 129 (6) ◽  
pp. 749-756 ◽  
Author(s):  
Diane C. Lockhart ◽  
Allen K. Chan ◽  
Simona Mak ◽  
Hong-Gu Joo ◽  
Heather A. Daust ◽  
...  
Keyword(s):  
T Cell ◽  
Ovarian Carcinoma ◽  
T Cell Receptor ◽  
Cell Function ◽  
Tumor Infiltrating Lymphocytes ◽  
Cell Receptor ◽  
T Cell Function ◽  
Infiltrating Lymphocytes

T cell function and expression are dramatically altered in T cell receptor Vγ1.1Jγ4Cγ4 transgenic mice

Cell ◽  
1989 ◽  
Vol 57 (3) ◽  
pp. 483-492 ◽  
Author(s):  
David A. Ferrick ◽  
Suryaprakash R. Sambhara ◽  
Wolfgang Ballhausen ◽  
Aikichi Iwamoto ◽  
Hanspeter Pircher ◽  
...  
Keyword(s):  
T Cell ◽  
Transgenic Mice ◽  
T Cell Receptor ◽  
Cell Function ◽  
Cell Receptor ◽  
T Cell Function

Redox regulation of T-cell receptor signaling

2015 ◽  
Vol 396 (5) ◽  
pp. 555-569 ◽  
Author(s):  
Luca Simeoni ◽  
Ivan Bogeski
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
T Cell Activation ◽  
Cell Activation ◽  
Redox Regulation ◽  
Molecular Mechanisms ◽  
Cell Function ◽  
Cell Receptor ◽  
T Cell Function

Abstract T-cell receptor (TCR) triggering by antigens activates a sophisticated intracellular signaling network leading to transcriptional activation, proliferation and differentiation of T cells. These events ultimately culminate in adaptive immune responses. Over recent years it has become evident that reactive oxygen species (ROS) play an important role in T-cell activation. It is now clear that ROS are involved in the regulation of T-cell mediated physiological and pathological processes. Upon TCR triggering, T cells produce oxidants, which originate from different cellular sources. In addition, within inflamed tissues, T cells are exposed to exocrine ROS produced by activated phagocytes or other ROS-producing cells. Oxidative modifications can have different effects on T-cell function. Indeed, they can stimulate T-cell activation but they can be also detrimental. These opposite effects of oxidation likely depend on different factors such as ROS concentration and source and also on the differentiation status of the T cells. Despite the well-stablished fact that ROS represent important modulators of T-cell activation, the precise molecular mechanisms of their action are far from clear. Here, we summarize the present knowledge on redox regulation of T-cell function with a particular emphasis on the redox regulation of TCR signaling.

scholarly journals Genetic disruption of p38α Tyr323 phosphorylation prevents T-cell receptor–mediated p38α activation and impairs interferon-γ production

Blood ◽  
2009 ◽  
Vol 113 (10) ◽  
pp. 2229-2237 ◽  
Author(s):  
Ludmila Jirmanova ◽  
Dandapantula N. Sarma ◽  
Dragana Jankovic ◽  
Paul R. Mittelstadt ◽  
Jonathan D. Ashwell
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Function ◽  
Alternative Pathway ◽  
Cell Receptor ◽  
Interferon Γ ◽  
Wild Type ◽  
T Helper 1 ◽  
Ifn Γ

AbstractT cells possess a p38 activation alternative pathway in which stimulation via the antigen receptor (T-cell receptor [TCR]) induces phosphorylation of p38α and β on Tyr323. To assess the contribution of this pathway to normal T-cell function, we generated p38α knockin mice in which Tyr323 was replaced with Phe (p38αY323F). TCR-mediated stimulation failed to activate p38αY323F as measured by phosphorylation of the Thr-Glu-Tyr activation motif and p38α catalytic activity. Cell-cycle entry was delayed in TCR-stimulated p38αY323F T cells, which also produced less interferon (IFN)–γ than wild-type T cells in response to TCR-mediated but not TCR-independent stimuli. p38αY323F mice immunized with T-helper 1 (Th1)–inducing antigens generated normal Th1 effector cells, but these cells produced less IFN-γ than wild-type cells when stimulated through the TCR. Thus, the Tyr323-dependent pathway and not the classic mitogen-activated protein (MAP) kinase cascade is the physiologic means of p38α activation through the TCR and is necessary for normal Th1 function but not Th1 generation.

scholarly journals The E3 Ubiquitin Ligase GRAIL Regulates T Cell Tolerance and Regulatory T Cell Function by Mediating T Cell Receptor-CD3 Degradation

Immunity ◽  
2010 ◽  
Vol 32 (5) ◽  
pp. 670-680 ◽  
Author(s):  
Roza I. Nurieva ◽  
Shuling Zheng ◽  
Wei Jin ◽  
Yeonseok Chung ◽  
Yongliang Zhang ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Ubiquitin Ligase ◽  
Regulatory T Cell ◽  
Cell Function ◽  
E3 Ubiquitin Ligase ◽  
Cell Receptor ◽  
T Cell Tolerance ◽  
Cell Tolerance ◽  
T Cell Function

scholarly journals Yellow Fever Virus, but Not Zika Virus or Dengue Virus, Inhibits T-Cell Receptor–Mediated T-Cell Function by an RNA-Based Mechanism

2017 ◽  
Vol 216 (9) ◽  
pp. 1164-1175 ◽  
Author(s):  
James H McLinden ◽  
Nirjal Bhattarai ◽  
Jack T Stapleton ◽  
Qing Chang ◽  
Thomas M Kaufman ◽  
...  
Keyword(s):  
T Cell ◽  
Dengue Virus ◽  
T Cell Receptor ◽  
Yellow Fever ◽  
Zika Virus ◽  
Cell Function ◽  
Yellow Fever Virus ◽  
Cell Receptor ◽  
Fever Virus ◽  
T Cell Function

scholarly journals Linc00402 Regulates Allogeneic T-Cell Function and T-Cell Receptor Signal Transduction

2021 ◽  
Vol 27 (3) ◽  
pp. S6-S7
Author(s):  
Daniel Peltier ◽  
Sethuramasundaram Pitchiaya ◽  
Visweswaran Ravikumar ◽  
Thomas Decoville ◽  
Sherri Wood ◽  
...  
Keyword(s):  
Signal Transduction ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Function ◽  
Cell Receptor ◽  
T Cell Function ◽  
Receptor Signal
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