Essential role of Src-family protein tyrosine kinases in NF-κB activation during B cell development

10.1038/ni893 ◽  
2003 ◽  
Vol 4 (3) ◽  
pp. 274-279 ◽  
Author(s):  
Kaoru Saijo ◽  
Christian Schmedt ◽  
I-hsin Su ◽  
Hajime Karasuyama ◽  
Clifford A. Lowell ◽  
...  
Keyword(s):  
B Cell ◽  
Tyrosine Kinases ◽  
Essential Role ◽  
Cell Development ◽  
B Cell Development ◽  
Protein Tyrosine Kinases ◽  
Protein Tyrosine ◽  
Family Protein

Association between B-lymphocyte membrane immunoglobulin and multiple members of the Src family of protein tyrosine kinases

1992 ◽  
Vol 12 (5) ◽  
pp. 2315-2321
Author(s):  
M A Campbell ◽  
B M Sefton
Keyword(s):  
B Cells ◽  
B Cell ◽  
Tyrosine Kinases ◽  
B Lymphocyte ◽  
Protein Tyrosine Kinases ◽  
Cell Type ◽  
Protein Tyrosine ◽  
Membrane Immunoglobulin ◽  
Family Protein

Treatment of B lymphocytes with antibodies to membrane immunoglobulin (Ig) stimulates protein tyrosine phosphorylation. We have examined the phosphorylation in vitro of proteins associated with membrane Ig. The Src family protein tyrosine kinases p53/56lyn, p59fyn, and p56lck are associated with membrane Ig in spleen B cells and B-cell lines and undergo phosphorylation in vitro. The pattern of expression of Src family protein tyrosine kinases in B cells varied. Our studies suggest that multiple kinases can potentially interact with membrane Ig and that within any one B-cell type, all of the Src family kinases expressed can be found in association with membrane Ig. We also observed that the Ig-associated Ig alpha protein, multiple forms of Ig beta, and proteins of 100 and 25 kDa were tyrosine phosphorylated in vitro. The 100- and 25-kDa proteins remain unidentified.

scholarly journals COX-1–derived thromboxane A2 plays an essential role in early B-cell development via regulation of JAK/STAT5 signaling in mouse

Blood ◽  
2014 ◽  
Vol 124 (10) ◽  
pp. 1610-1621 ◽  
Author(s):  
Qiong Yang ◽  
Maohua Shi ◽  
Yujun Shen ◽  
Yingjiao Cao ◽  
Shengkai Zuo ◽  
...  
Keyword(s):  
B Cell ◽  
Essential Role ◽  
Suppressive Effect ◽  
Cell Development ◽  
B Cell Development ◽  
Dose Aspirin ◽  
Key Points ◽  
Low Dose Aspirin ◽  
Cox 1

Key Points This study demonstrated an essential role of COX-1 in early B-cell development. Low-dose aspirin may have a potential suppressive effect on B-cell development in humans.

scholarly journals Cutting Edge: Essential Role of Phospholipase C-γ2 in B Cell Development and Function

2000 ◽  
Vol 165 (4) ◽  
pp. 1738-1742 ◽  
Author(s):  
Ari Hashimoto ◽  
Kiyoshi Takeda ◽  
Muneo Inaba ◽  
Masayuki Sekimata ◽  
Tsuneyasu Kaisho ◽  
...  
Keyword(s):  
B Cell ◽  
Phospholipase C ◽  
Essential Role ◽  
Cell Development ◽  
B Cell Development ◽  
Cutting Edge ◽  
And Function

scholarly journals Association between B-lymphocyte membrane immunoglobulin and multiple members of the Src family of protein tyrosine kinases.

1992 ◽  
Vol 12 (5) ◽  
pp. 2315-2321 ◽  
Author(s):  
M A Campbell ◽  
B M Sefton
Keyword(s):  
B Cells ◽  
B Cell ◽  
Tyrosine Kinases ◽  
B Lymphocyte ◽  
Protein Tyrosine Kinases ◽  
Cell Type ◽  
Protein Tyrosine ◽  
Membrane Immunoglobulin ◽  
Family Protein

Treatment of B lymphocytes with antibodies to membrane immunoglobulin (Ig) stimulates protein tyrosine phosphorylation. We have examined the phosphorylation in vitro of proteins associated with membrane Ig. The Src family protein tyrosine kinases p53/56lyn, p59fyn, and p56lck are associated with membrane Ig in spleen B cells and B-cell lines and undergo phosphorylation in vitro. The pattern of expression of Src family protein tyrosine kinases in B cells varied. Our studies suggest that multiple kinases can potentially interact with membrane Ig and that within any one B-cell type, all of the Src family kinases expressed can be found in association with membrane Ig. We also observed that the Ig-associated Ig alpha protein, multiple forms of Ig beta, and proteins of 100 and 25 kDa were tyrosine phosphorylated in vitro. The 100- and 25-kDa proteins remain unidentified.

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