Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell–mediated immune responses

Jr-Wen Shui; Jonathan S Boomer; Jin Han; Jun Xu; Gregory A Dement; Guisheng Zhou; Tse-Hua Tan

doi:10.1038/ni1416

Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell–mediated immune responses

Nature Immunology ◽

10.1038/ni1416 ◽

2006 ◽

Vol 8 (1) ◽

pp. 84-91 ◽

Cited By ~ 94

Author(s):

Jr-Wen Shui ◽

Jonathan S Boomer ◽

Jin Han ◽

Jun Xu ◽

Gregory A Dement ◽

...

Keyword(s):

T Cell ◽

Immune Responses ◽

T Cell Receptor ◽

Cell Receptor ◽

Receptor Signaling ◽

Hematopoietic Progenitor ◽

T Cell Receptor Signaling ◽

Cell Receptor Signaling

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Infant T cells are developmentally adapted for robust lung immune responses through enhanced T cell receptor signaling

Science Immunology ◽

10.1126/sciimmunol.abj0789 ◽

2021 ◽

Vol 6 (66) ◽

Author(s):

Puspa Thapa ◽

Rebecca S. Guyer ◽

Alexander Y. Yang ◽

Christopher A. Parks ◽

Todd M. Brusko ◽

...

Keyword(s):

T Cells ◽

T Cell ◽

Immune Responses ◽

T Cell Receptor ◽

Cell Receptor ◽

Receptor Signaling ◽

T Cell Receptor Signaling ◽

Cell Receptor Signaling

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Involvement of Hematopoietic Progenitor Kinase 1 in T Cell Receptor Signaling

Journal of Biological Chemistry ◽

10.1074/jbc.m101485200 ◽

2001 ◽

Vol 276 (22) ◽

pp. 18908-18914 ◽

Cited By ~ 39

Author(s):

Pin Ling ◽

Christian F. Meyer ◽

Lisa P. Redmond ◽

Jr-Wen Shui ◽

Beckley Davis ◽

...

Keyword(s):

T Cell ◽

T Cell Receptor ◽

Cell Receptor ◽

Receptor Signaling ◽

Hematopoietic Progenitor ◽

T Cell Receptor Signaling ◽

Cell Receptor Signaling

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Faculty Opinions recommendation of T cell receptor signaling precedes immunological synapse formation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1004974.58104 ◽

2002 ◽

Author(s):

Andre Veillette

Keyword(s):

T Cell ◽

T Cell Receptor ◽

Synapse Formation ◽

Immunological Synapse ◽

Cell Receptor ◽

Receptor Signaling ◽

T Cell Receptor Signaling ◽

Cell Receptor Signaling

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Faculty Opinions recommendation of Regulation of T cell receptor signaling by activation-induced zinc influx.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.10059956.11264055 ◽

2011 ◽

Author(s):

Donna Farber ◽

Minjun Yu

Keyword(s):

T Cell ◽

T Cell Receptor ◽

Cell Receptor ◽

Receptor Signaling ◽

T Cell Receptor Signaling ◽

Cell Receptor Signaling

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Faculty Opinions recommendation of T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13373008.15147061 ◽

2012 ◽

Author(s):

Elizabeth Mellins ◽

Michael Strohman

Keyword(s):

Major Histocompatibility Complex ◽

T Cell ◽

T Cell Receptor ◽

Cell Receptor ◽

Receptor Signaling ◽

Major Histocompatibility ◽

Histocompatibility Complex ◽

T Cell Receptor Signaling ◽

Cell Receptor Signaling

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Faculty Opinions recommendation of The Ca(v)1.4 calcium channel is a critical regulator of T cell receptor signaling and naive T cell homeostasis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13411045.14782172 ◽

2011 ◽

Author(s):

Markus Hoth

Keyword(s):

T Cell ◽

Calcium Channel ◽

T Cell Receptor ◽

Cell Receptor ◽

Receptor Signaling ◽

T Cell Homeostasis ◽

Cell Homeostasis ◽

T Cell Receptor Signaling ◽

Cell Receptor Signaling ◽

Naive T Cell

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Faculty Opinions recommendation of Distinct temporal patterns of T cell receptor signaling during positive versus negative selection in situ.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718145624.793487806 ◽

2013 ◽

Author(s):

Valerie Horsley ◽

Natalie Roberts

Keyword(s):

T Cell ◽

T Cell Receptor ◽

Negative Selection ◽

Temporal Patterns ◽

Cell Receptor ◽

Receptor Signaling ◽

T Cell Receptor Signaling ◽

Cell Receptor Signaling

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Faculty Opinions recommendation of Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.723619637.793515738 ◽

2016 ◽

Author(s):

Miguel Vicente-Manzanares

Keyword(s):

Cell Death ◽

T Cell ◽

Programmed Cell Death ◽

T Cell Receptor ◽

Cell Receptor ◽

Receptor Signaling ◽

Programmed Cell Death 1 ◽

T Cell Receptor Signaling ◽

Cell Receptor Signaling

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Faculty Opinions recommendation of Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726375245.793551467 ◽

2018 ◽

Author(s):

Andrea Reboldi

Keyword(s):

T Cell ◽

T Cell Receptor ◽

Cell Receptor ◽

Membrane Cholesterol ◽

Receptor Signaling ◽

Cholesterol Sulfate ◽

Naturally Occurring ◽

T Cell Receptor Signaling ◽

Cell Receptor Signaling

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Faculty Opinions recommendation of Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726922889.793528475 ◽

2017 ◽

Author(s):

Benjamin Kile

Keyword(s):

T Cell ◽

T Cell Receptor ◽

Cell Receptor ◽

T Cell Exhaustion ◽

Receptor Signaling ◽

Cell Exhaustion ◽

T Cell Receptor Signaling ◽

Cell Receptor Signaling

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