Selection of the cutaneous intraepithelial γδ+ T cell repertoire by a thymic stromal determinant

2006 ◽  
Vol 7 (8) ◽  
pp. 843-850 ◽  
Author(s):  
Julia M Lewis ◽  
Michael Girardi ◽  
Scott J Roberts ◽  
Susannah D Barbee ◽  
Adrian C Hayday ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Repertoire ◽  
Γδ T Cell ◽  
Cell Repertoire ◽  
Selection Of

Age-associated alteration of γδ T-cell repertoire and different profiles of activation-induced death of Vδ1 and Vδ2 T cells

2011 ◽  
Vol 94 (3) ◽  
pp. 230-240 ◽  
Author(s):  
Yoshihiro Michishita ◽  
Makoto Hirokawa ◽  
Yong-Mei Guo ◽  
Yukiko Abe ◽  
Jiajia Liu ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Repertoire ◽  
Γδ T Cell ◽  
Cell Repertoire

Homogeneous epithelial γδ T cell repertoire of the skin is shaped through peripheral selection

2001 ◽  
Vol 25 (2) ◽  
pp. 150-155 ◽  
Author(s):  
Masahiro Minagawa ◽  
Akiko Ito ◽  
Hideki Shimura ◽  
Katsuhiro Tomiyama ◽  
Masaaki Ito ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Repertoire ◽  
Γδ T Cell ◽  
Cell Repertoire

scholarly journals Changes in Human Mucosal γδ T Cell Repertoire and Function Associated with the Disease Process in Inflammatory Bowel Disease

1997 ◽  
Vol 3 (3) ◽  
pp. 183-203 ◽  
Author(s):  
Laila D. McVay ◽  
Baiqing Li ◽  
Renée Biancaniello ◽  
Mary Anne Creighton ◽  
Dale Bachwich ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
T Cell ◽  
Bowel Disease ◽  
Disease Process ◽  
T Cell Repertoire ◽  
Γδ T Cell ◽  
Cell Repertoire ◽  
Inflammatory Bowel ◽  
And Function

scholarly journals The Thymus Contains a High Frequency of Cells that Prevent Autoimmune Diabetes on Transfer into Prediabetic Recipients

1996 ◽  
Vol 184 (6) ◽  
pp. 2393-2398 ◽  
Author(s):  
Abdelhadi Saoudi ◽  
Benedict Seddon ◽  
Debbie Fowell ◽  
Don Mason
Keyword(s):  
T Cells ◽  
T Cell ◽  
Intravenous Injection ◽  
High Frequency ◽  
Autoimmune Diabetes ◽  
T Cell Repertoire ◽  
Γ Irradiation ◽  
Cell Repertoire ◽  
Peripheral T Cells ◽  
Selection Of

Rats of the PVG.RT1u strain develop autoimmune diabetes when thymectomized at 6 wk of age and are rendered relatively lymphopenic by a cumulative dose of 1,000 rads 137Cs γ-irradiation given in four split doses. Previous studies have shown that the disease is prevented by the intravenous injection of 5 × 106 CD4+ CD45RC− TCRαβ+ RT6+ peripheral T cells from normal syngeneic donors. These cells have a memory phenotype and are presumably primed to some extrathymic antigen. However, we now report that the CD4+ CD8− population of mature thymocytes is a very potent source of cells, with the capacity to prevent diabetes in our lymphopenic animals. As few as 6 × 105 of these cells protect ∼50% of recipients and the level of protection increases with cell dose. It appears that one characteristic of the intrathymic selection of the T cell repertoire is the generation of cells that regulate the autoimmune potential of peripheral T cells that have been neither clonally deleted intrathymically nor rendered irreversibly anergic in the periphery.

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