S100-alarmin-induced innate immune programming protects newborn infants from sepsis

2017 ◽  
Vol 18 (6) ◽  
pp. 622-632 ◽  
Author(s):  
Thomas Ulas ◽  
Sabine Pirr ◽  
Beate Fehlhaber ◽  
Marie S Bickes ◽  
Torsten G Loof ◽  
...  
Keyword(s):  
Newborn Infants ◽  
Innate Immune ◽  
Immune Programming

scholarly journals Erratum: Corrigendum: S100-alarmin-induced innate immune programming protects newborn infants from sepsis

2017 ◽  
Vol 18 (10) ◽  
pp. 1173-1173 ◽  
Author(s):  
Thomas Ulas ◽  
Sabine Pirr ◽  
Beate Fehlhaber ◽  
Marie S Bickes ◽  
Torsten G Loof ◽  
...  
Keyword(s):  
Newborn Infants ◽  
Innate Immune ◽  
Immune Programming

scholarly journals Characterisation of morphological differences in well-differentiated nasal epithelial cell cultures from preterm and term infants at birth and one-year

2018 ◽  
Author(s):  
Helen E. Groves ◽  
Hong Guo-Parke ◽  
Lindsay Broadbent ◽  
Michael D. Shields ◽  
Ultan F. Power
Keyword(s):  
Epithelial Cell ◽  
Immune Responses ◽  
Airway Epithelium ◽  
Newborn Infants ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Nasal Epithelial Cell ◽  
Age Related ◽  
Well Differentiated ◽  
One Year

AbstractBackgroundInnate immune responses of airway epithelium are important defences against respiratory pathogens and allergens. Newborn infants are at greater risk of severe respiratory infections compared to older infants. However, very little is known regarding human neonatal airway epithelium immune responses and whether age-related morphological and/or innate immune changes contribute to the development of airway disease.MethodsWe collected nasal epithelial cells from 41 newborn infants (23 term, 18 preterm) within 5 days of birth. Repeat sampling was achieved for 24 infants (13 term, 11 preterm) at a median age of 12.5 months. Morphologically and physiologically authentic well-differentiated primary paediatric nasal epithelial cell (WD-PNEC) cultures were generated and characterised using light microscopy and immunofluorescence.ResultsWD-PNEC cultures were established for 15/23 (65%) term and 13/18 (72%) preterm samples at birth, and 9/13 (69%) term and 8/11 (73%) preterm samples at one-year. Newborn and infant WD-PNEC cultures demonstrated extensive cilia coverage, mucous production and tight junction integrity. Newborn WD-PNECs took significantly longer to reach full differentiation and were noted to have much greater proportions of goblet cells compared to one-year repeat WD-PNECs. No differences were evident in ciliated/goblet cell proportions between term- and preterm-derived WD-PNECs at birth or one-year old.ConclusionWD-PNEC culture generation from newborn infants is feasible and represents a powerful and exciting opportunity to study differential innate immune responses in human airway epithelium very early in life.

Oral Immune Activation by Disgust and Disease-Related Pictures

2015 ◽  
Vol 29 (3) ◽  
pp. 119-129 ◽  
Author(s):  
Richard J. Stevenson ◽  
Deborah Hodgson ◽  
Megan J. Oaten ◽  
Luba Sominsky ◽  
Mehmet Mahmut ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Innate Immune Response ◽  
Negative Control ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Immune Markers ◽  
Before And After ◽  
Secondary Analyses ◽  
Image Set

Abstract. Both disgust and disease-related images appear able to induce an innate immune response but it is unclear whether these effects are independent or rely upon a common shared factor (e.g., disgust or disease-related cognitions). In this study we directly compared these two inductions using specifically generated sets of images. One set was disease-related but evoked little disgust, while the other set was disgust evoking but with less disease-relatedness. These two image sets were then compared to a third set, a negative control condition. Using a wholly within-subject design, participants viewed one image set per week, and provided saliva samples, before and after each viewing occasion, which were later analyzed for innate immune markers. We found that both the disease related and disgust images, relative to the negative control images, were not able to generate an innate immune response. However, secondary analyses revealed innate immune responses in participants with greater propensity to feel disgust following exposure to disease-related and disgusting images. These findings suggest that disgust images relatively free of disease-related themes, and disease-related images relatively free of disgust may be suboptimal cues for generating an innate immune response. Not only may this explain why disgust propensity mediates these effects, it may also imply a common pathway.

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