The skin-resident and migratory immune system in steady state and memory: innate lymphocytes, dendritic cells and T cells

2013 ◽  
Vol 14 (10) ◽  
pp. 978-985 ◽  
Author(s):  
William R Heath ◽  
Francis R Carbone
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Steady State ◽  
Immune System ◽  
Innate Lymphocytes

scholarly journals The proliferative response of CD4 T cells to steady-state CD8+ dendritic cells is restricted by post-activation death

2006 ◽  
Vol 18 (3) ◽  
pp. 415-423 ◽  
Author(s):  
Alexandra Rizzitelli ◽  
Edwin Hawkins ◽  
Hilary Todd ◽  
Philip D. Hodgkin ◽  
Ken Shortman
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Steady State ◽  
Cd4 T Cells ◽  
Proliferative Response

scholarly journals Common variable immunodeficiency – case report

2013 ◽  
Vol 3 (2) ◽  
pp. 170-172
Author(s):  
Emina Vukas ◽  
Aida Dizdarević ◽  
Senka Mesihović - Dinarević ◽  
Adisa Čengić
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Case Report ◽  
Immune System ◽  
Primary Immunodeficiency ◽  
Common Variable Immunodeficiency ◽  
Clinical Picture ◽  
Clinical Signs ◽  
Common Variable

Common variable immunodeficiency (CVID) or acquired hypogammaglobulinemia is the type of primary immunodeficiency. Deregulation of the immune system, leading to hypogammaglobulinemia, defective activation and proliferation of T cells and dendritic cells, and malfunction of the cytokines are observed in CVID. The clinical picture of CVID varies, any organ or system can be affected, therefore the diagnosis is often difficult and delayed and sometimes is not always possible. This article describes a twelve years old boy with all the clinical signs of immunodeficiency, as confi rmed by laboratory. The main treatment consists of life-long immunoglobulin substitution in intravenous or subcutaneous form.

scholarly journals FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells

2009 ◽  
Vol 107 (1) ◽  
pp. 199-203 ◽  
Author(s):  
A. Schildknecht ◽  
S. Brauer ◽  
C. Brenner ◽  
K. Lahl ◽  
H. Schild ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Steady State ◽  
T Cell ◽  
Regulatory T Cells ◽  
Cd8 T Cell ◽  
T Cell Tolerance ◽  
Cell Tolerance

Steady-state dendritic cells expressing cognate antigen terminate memory CD8+ T-cell responses

Blood ◽  
2008 ◽  
Vol 111 (4) ◽  
pp. 2091-2100 ◽  
Author(s):  
Tony J. Kenna ◽  
Ranjeny Thomas ◽  
Raymond J. Steptoe
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Steady State ◽  
T Cell ◽  
Developmental Plasticity ◽  
Naive T Cells ◽  
Naïve T Cells ◽  
Cognate Antigen ◽  
Costimulatory Signals

Antigen stimulation of naive T cells in conjunction with strong costimulatory signals elicits the generation of effector and memory populations. Such terminal differentiation transforms naive T cells capable of differentiating along several terminal pathways in response to pertinent environmental cues into cells that have lost developmental plasticity and exhibit heightened responsiveness. Because these cells exhibit little or no need for the strong costimulatory signals required for full activation of naive T cells, it is generally considered memory and effector T cells are released from the capacity to be inactivated. Here, we show that steady-state dendritic cells constitutively presenting an endogenously expressed antigen inactivate fully differentiated memory and effector CD8+ T cells in vivo through deletion and inactivation. These findings indicate that fully differentiated effector and memory T cells exhibit a previously unappreciated level of plasticity and provide insight into how memory and effector T-cell populations may be regulated.

scholarly journals Steady state migratory RelB+ langerin+ dermal dendritic cells mediate peripheral induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells

2011 ◽  
Vol 41 (5) ◽  
pp. 1420-1434 ◽  
Author(s):  
Hiroaki Azukizawa ◽  
Anja Döhler ◽  
Nobuo Kanazawa ◽  
Arnab Nayak ◽  
Martin Lipp ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Steady State ◽  
Regulatory T Cells

scholarly journals RelB+ Steady-State Migratory Dendritic Cells Control the Peripheral Pool of the Natural Foxp3+ Regulatory T Cells

2017 ◽  
Vol 8 ◽  
Author(s):  
Anja Döhler ◽  
Theresa Schneider ◽  
Ina Eckert ◽  
Eliana Ribechini ◽  
Nico Andreas ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Steady State ◽  
Regulatory T Cells

scholarly journals DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8+ T cells independently of PD-1 and PD-L1

2013 ◽  
Vol 25 (11) ◽  
pp. 651-660 ◽  
Author(s):  
Gayatri Mukherjee ◽  
Ari Geliebter ◽  
Jeffrey Babad ◽  
Pere Santamaria ◽  
David V. Serreze ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Steady State ◽  
Cd8 T Cells
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