A BATF-ling connection between B cells and follicular helper T cells

2011 ◽  
Vol 12 (6) ◽  
pp. 519-520 ◽  
Author(s):  
Julia I Ellyard ◽  
Carola G Vinuesa
Keyword(s):  
T Cells ◽  
B Cells ◽  
Helper T Cells ◽  
Follicular Helper T Cells ◽  
Follicular Helper

scholarly journals CD10 delineates a subset of human IL-4 producing follicular helper T cells involved in the survival of follicular lymphoma B cells

Blood ◽  
2015 ◽  
Vol 125 (15) ◽  
pp. 2381-2385 ◽  
Author(s):  
Patricia Amé-Thomas ◽  
Sylvia Hoeller ◽  
Catherine Artchounin ◽  
Jan Misiak ◽  
Mounia Sabrina Braza ◽  
...  
Keyword(s):  
T Cells ◽  
B Cells ◽  
Follicular Lymphoma ◽  
B Cell ◽  
Germinal Center ◽  
Helper T Cells ◽  
Follicular Helper T Cells ◽  
Follicular Helper ◽  
Key Points ◽  
Cell Niche

Key Points CD10 identifies a unique subset of fully functional germinal center TFH that are activated and amplified within the FL cell niche. FL CD10pos TFH specifically display an IL-4hiIFN-γlo cytokine profile and encompass the malignant B-cell-supportive TFH subset.

scholarly journals Intralymphatic GAD-alum Injection Modulates B Cell Response and Induces Follicular Helper T Cells and PD-1+ CD8+ T Cells in Patients With Recent-Onset Type 1 Diabetes

2022 ◽  
Vol 12 ◽  
Author(s):  
Hugo Barcenilla ◽  
Mikael Pihl ◽  
Jeanette Wahlberg ◽  
Johnny Ludvigsson ◽  
Rosaura Casas
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
B Cells ◽  
Lymph Nodes ◽  
Cd8 T Cells ◽  
Helper T Cells ◽  
Follicular Helper T Cells ◽  
Recent Onset ◽  
Follicular Helper

Antigen-specific immunotherapy is an appealing strategy to preserve beta-cell function in type 1 diabetes, although the approach has yet to meet its therapeutic endpoint. Direct administration of autoantigen into lymph nodes has emerged as an alternative administration route that can improve the efficacy of the treatment. In the first open-label clinical trial in humans, injection of aluminum-formulated glutamic acid decarboxylase (GAD-alum) into an inguinal lymph node led to the promising preservation of C-peptide in patients with recent-onset type 1 diabetes. The treatment induced a distinct immunomodulatory effect, but the response at the cell level has not been fully characterized. Here we used mass cytometry to profile the immune landscape in peripheral blood mononuclear cells from 12 participants of the study before and after 15 months of treatment. The immunomodulatory effect of the therapy included reduction of naïve and unswitched memory B cells, increase in follicular helper T cells and expansion of PD-1+ CD69+ cells in both CD8+ and double negative T cells. In vitro stimulation with GAD65 only affected effector CD8+ T cells in samples collected before the treatment. However, the recall response to antigen after 15 months included induction of CXCR3+ and CD11c+Tbet+ B cells, PD-1+ follicular helper T cells and exhausted-like CD8+ T cells. This study provides a deeper insight into the immunological changes associated with GAD-alum administration directly into the lymph nodes.

scholarly journals Alteration of circulating type 2 follicular helper T cells and regulatory B cells underlies the comorbid association of allergic rhinitis with bronchial asthma

2015 ◽  
Vol 158 (2) ◽  
pp. 204-211 ◽  
Author(s):  
Ryuta Kamekura ◽  
Katsunori Shigehara ◽  
Satsuki Miyajima ◽  
Sumito Jitsukawa ◽  
Koji Kawata ◽  
...  
Keyword(s):  
T Cells ◽  
Allergic Rhinitis ◽  
B Cells ◽  
Bronchial Asthma ◽  
Helper T Cells ◽  
Regulatory B Cells ◽  
Follicular Helper T Cells ◽  
Follicular Helper

scholarly journals Imbalance favoring follicular helper T cells over IL10+ regulatory B cells is detrimental for the kidney allograft

2020 ◽  
Vol 98 (3) ◽  
pp. 732-743 ◽  
Author(s):  
Rocio Laguna-Goya ◽  
Alberto Utrero-Rico ◽  
Francisco Luis Cano-Romero ◽  
Elena Gómez-Massa ◽  
Esther González ◽  
...  
Keyword(s):  
T Cells ◽  
B Cells ◽  
Helper T Cells ◽  
Regulatory B Cells ◽  
Follicular Helper T Cells ◽  
Kidney Allograft ◽  
Follicular Helper

scholarly journals Memory B cells contribute to rapid Bcl6 expression by memory follicular helper T cells

2014 ◽  
Vol 111 (32) ◽  
pp. 11792-11797 ◽  
Author(s):  
W. Ise ◽  
T. Inoue ◽  
J. B. McLachlan ◽  
K. Kometani ◽  
M. Kubo ◽  
...  
Keyword(s):  
T Cells ◽  
B Cells ◽  
Memory B Cells ◽  
Helper T Cells ◽  
Follicular Helper T Cells ◽  
Follicular Helper ◽  
Bcl6 Expression

scholarly journals Proportions of circulating follicular helper T cells are reduced and correlate with memory B cells in HIV-infected children

PLoS ONE ◽  
2017 ◽  
Vol 12 (4) ◽  
pp. e0175570 ◽  
Author(s):  
Daniel M. Muema ◽  
Gladys N. Macharia ◽  
Babatunde A. Olusola ◽  
Amin S. Hassan ◽  
Greg W. Fegan ◽  
...  
Keyword(s):  
T Cells ◽  
B Cells ◽  
Memory B Cells ◽  
Helper T Cells ◽  
Follicular Helper T Cells ◽  
Follicular Helper ◽  
With Memory
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