scholarly journals TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

2010 ◽  
Vol 11 (5) ◽  
pp. 411-418 ◽  
Author(s):  
Fabio Martinon ◽  
Xi Chen ◽  
Ann-Hwee Lee ◽  
Laurie H Glimcher
Keyword(s):  
Transcription Factor ◽  
Immune Responses ◽  
Innate Immune ◽  
Innate Immune Responses

scholarly journals NSD3 keeps IRF3 active

2017 ◽  
Vol 214 (12) ◽  
pp. 3475-3476
Author(s):  
Takashi Mino ◽  
Osamu Takeuchi
Keyword(s):  
Transcription Factor ◽  
Immune Responses ◽  
Transcriptional Activity ◽  
Innate Immune ◽  
Innate Immune Responses

In this issue of JEM, Wang et al. (https://doi.org/10.1084/jem.20170856) show a novel antiviral innate mechanism by which methyltransferase NSD3 directly monomethylates a transcription factor IRF3 and maintains IRF3 phosphorylation to enhance its transcriptional activity, consequently promoting antiviral innate immune responses.

scholarly journals Lysosomal Protein Lamtor1 Controls Innate Immune Responses via Nuclear Translocation of Transcription Factor EB

2018 ◽  
Vol 200 (11) ◽  
pp. 3790-3800 ◽  
Author(s):  
Yoshitomo Hayama ◽  
Tetsuya Kimura ◽  
Yoshito Takeda ◽  
Shigeyuki Nada ◽  
Shohei Koyama ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Immune Responses ◽  
Nuclear Translocation ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Transcription Factor Eb ◽  
Lysosomal Protein

scholarly journals A conserved role for a GATA transcription factor in regulating epithelial innate immune responses

2006 ◽  
Vol 103 (38) ◽  
pp. 14086-14091 ◽  
Author(s):  
M. Shapira ◽  
B. J. Hamlin ◽  
J. Rong ◽  
K. Chen ◽  
M. Ronen ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Immune Responses ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Gata Transcription Factor

Oral Immune Activation by Disgust and Disease-Related Pictures

2015 ◽  
Vol 29 (3) ◽  
pp. 119-129 ◽  
Author(s):  
Richard J. Stevenson ◽  
Deborah Hodgson ◽  
Megan J. Oaten ◽  
Luba Sominsky ◽  
Mehmet Mahmut ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Innate Immune Response ◽  
Negative Control ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Immune Markers ◽  
Before And After ◽  
Secondary Analyses ◽  
Image Set

Abstract. Both disgust and disease-related images appear able to induce an innate immune response but it is unclear whether these effects are independent or rely upon a common shared factor (e.g., disgust or disease-related cognitions). In this study we directly compared these two inductions using specifically generated sets of images. One set was disease-related but evoked little disgust, while the other set was disgust evoking but with less disease-relatedness. These two image sets were then compared to a third set, a negative control condition. Using a wholly within-subject design, participants viewed one image set per week, and provided saliva samples, before and after each viewing occasion, which were later analyzed for innate immune markers. We found that both the disease related and disgust images, relative to the negative control images, were not able to generate an innate immune response. However, secondary analyses revealed innate immune responses in participants with greater propensity to feel disgust following exposure to disease-related and disgusting images. These findings suggest that disgust images relatively free of disease-related themes, and disease-related images relatively free of disgust may be suboptimal cues for generating an innate immune response. Not only may this explain why disgust propensity mediates these effects, it may also imply a common pathway.

Innate immune responses and type 1 diabetes: A role for a long non-coding RNA?

2014 ◽  
Vol 9 (S 01) ◽  
Author(s):  
MP Ashton ◽  
I Tan ◽  
L Mackin ◽  
C Elso ◽  
E Chu ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Immune Responses ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Non Coding Rna ◽  
Long Non Coding Rna
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