scholarly journals Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating β2 integrins

2008 ◽  
Vol 9 (8) ◽  
pp. 880-886 ◽  
Author(s):  
Jingsong Xu ◽  
Xiao-Pei Gao ◽  
Ramaswamy Ramchandran ◽  
You-Yang Zhao ◽  
Stephen M Vogel ◽  
...  
Keyword(s):  
Light Chain ◽  
Lung Inflammation ◽  
Myosin Light Chain Kinase ◽  
Myosin Light Chain ◽  
Nonmuscle Myosin ◽  
Β2 Integrins

scholarly journals MicroRNA Regulation of Nonmuscle Myosin Light Chain Kinase Expression in Human Lung Endothelium

2013 ◽  
Vol 49 (1) ◽  
pp. 58-66 ◽  
Author(s):  
Djanybek M. Adyshev ◽  
Nurgul Moldobaeva ◽  
Brandon Mapes ◽  
Venkate Elangovan ◽  
Joe G. N. Garcia
Keyword(s):  
Light Chain ◽  
Myosin Light Chain Kinase ◽  
Myosin Light Chain ◽  
Human Lung ◽  
Nonmuscle Myosin ◽  
Microrna Regulation ◽  
Lung Endothelium ◽  
Kinase Expression

scholarly journals Nonmuscle Myosin IIA Regulates Platelet Contractile Forces Through Rho Kinase and Myosin Light-Chain Kinase

2016 ◽  
Vol 138 (10) ◽  
Author(s):  
Shirin Feghhi ◽  
Wes W. Tooley ◽  
Nathan J. Sniadecki
Keyword(s):  
Atpase Activity ◽  
Light Chain ◽  
Myosin Light Chain Kinase ◽  
Myosin Light Chain ◽  
Rho Kinase ◽  
Myosin Atpase ◽  
Nonmuscle Myosin ◽  
Myosin Phosphorylation ◽  
Myosin Atpase Activity ◽  
Contractile Forces

Platelet contractile forces play a major role in clot retraction and help to hold hemostatic clots against the vessel wall. Platelet forces are produced by its cytoskeleton, which is composed of actin and nonmuscle myosin filaments. In this work, we studied the role of Rho kinase, myosin light-chain kinase, and myosin in the generation of contractile forces by using pharmacological inhibitors and arrays of flexible microposts to measure platelet forces. When platelets were seeded onto microposts, they formed aggregates on the tips of the microposts. Forces produced by the platelets in the aggregates were measured by quantifying the deflection of the microposts, which bent in proportion to the force of the platelets. Platelets were treated with small molecule inhibitors of myosin activity: Y-27632 to inhibit the Rho kinase (ROCK), ML-7 to inhibit myosin light-chain kinase (MLCK), and blebbistatin to inhibit myosin ATPase activity. ROCK inhibition reduced platelet forces, demonstrating the importance of the assembly of actin and myosin phosphorylation in generating contractile forces. Similarly, MLCK inhibition caused weaker platelet forces, which verifies that myosin phosphorylation is needed for force generation in platelets. Platelets treated with blebbistatin also had weaker forces, which indicates that myosin's ATPase activity is necessary for platelet forces. Our studies demonstrate that myosin ATPase activity and the regulation of actin–myosin assembly by ROCK and MLCK are needed for the generation of platelet forces. Our findings illustrate and explain the importance of myosin for clot compaction in hemostasis and thrombosis.

scholarly journals Nonmuscle Myosin Light Chain Kinase Activity Modulates Radiation-Induced Lung Injury

2016 ◽  
Vol 6 (2) ◽  
pp. 234-239 ◽  
Author(s):  
Ting Wang ◽  
Biji Mathew ◽  
Xiaomin Wu ◽  
Yuka Shimizu ◽  
Alicia N. Rizzo ◽  
...  
Keyword(s):  
Lung Injury ◽  
Light Chain ◽  
Myosin Light Chain Kinase ◽  
Myosin Light Chain ◽  
Kinase Activity ◽  
Nonmuscle Myosin ◽  
Radiation Induced

scholarly journals Nonmuscle Myosin Light Chain Kinase: A Key Player in Intermittent Hypoxia‐Induced Vascular Alterations

2018 ◽  
Vol 7 (3) ◽  
Author(s):  
Claire Arnaud ◽  
Sophie Bouyon ◽  
Sylvain Recoquillon ◽  
Sandrine Brasseur ◽  
Emeline Lemarié ◽  
...  
Keyword(s):  
Light Chain ◽  
Myosin Light Chain Kinase ◽  
Intermittent Hypoxia ◽  
Myosin Light Chain ◽  
Nonmuscle Myosin ◽  
Kinase A

Nonmuscle Myosin Light Chain Kinase

2012 ◽  
pp. 1254-1254
Author(s):  
Rüdiger Horstkorte ◽  
Bettina Büttner ◽  
Kaya Bork ◽  
Navdeep Sahota ◽  
Sarah Sabir ◽  
...  
Keyword(s):  
Light Chain ◽  
Myosin Light Chain Kinase ◽  
Myosin Light Chain ◽  
Nonmuscle Myosin
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