Digenic inheritance of severe insulin resistance in a human pedigree

10.1038/ng926 ◽  
2002 ◽  
Vol 31 (4) ◽  
pp. 379-384 ◽  
Author(s):  
David B. Savage ◽  
Maura Agostini ◽  
Inês Barroso ◽  
Mark Gurnell ◽  
Jian'an Luan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Severe Insulin Resistance ◽  
Digenic Inheritance

scholarly journals Erratum: Digenic inheritance of severe insulin resistance in a human pedigree

2002 ◽  
Vol 32 (1) ◽  
pp. 211-211 ◽  
Author(s):  
D B Savage ◽  
M Agostini ◽  
I Barroso ◽  
M Gurnell ◽  
J Luan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Severe Insulin Resistance ◽  
Digenic Inheritance

In vivo chloroquine-induced inhibition of insulin degradation in a diabetic patient with severe insulin resistance

Diabetes ◽  
1984 ◽  
Vol 33 (12) ◽  
pp. 1133-1137 ◽  
Author(s):  
B. R. Blazar ◽  
C. B. Whitley ◽  
A. E. Kitabchi ◽  
M. Y. Tsai ◽  
J. Santiago ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Diabetic Patient ◽  
Insulin Degradation ◽  
Severe Insulin Resistance

scholarly journals Structural Basis and Genotype–Phenotype Correlations of INSR Mutations Causing Severe Insulin Resistance

Diabetes ◽  
2017 ◽  
Vol 66 (10) ◽  
pp. 2713-2723 ◽  
Author(s):  
Jun Hosoe ◽  
Hiroko Kadowaki ◽  
Fuyuki Miya ◽  
Katsuya Aizu ◽  
Tomoyuki Kawamura ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Structural Basis ◽  
Severe Insulin Resistance

Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus

1982 ◽  
Vol 243 (1) ◽  
pp. E15-E30 ◽  
Author(s):  
J. M. Olefsky ◽  
O. G. Kolterman ◽  
J. A. Scarlett
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Insulin Receptor ◽  
Insulin Action ◽  
Insulin Receptors ◽  
Tissue Level ◽  
Dependent Diabetes Mellitus ◽  
Target Tissue ◽  
Severe Insulin Resistance ◽  
Glucose Clamp Technique

Resistance to the action of insulin can result from a variety of causes, including the formation of abnormal insulin or proinsulin molecules, the presence of circulating antagonists to insulin or the insulin receptor, or defects in insulin action at the target tissue level. Defects of the latter type are characteristic of obesity and of noninsulin-dependent diabetes mellitus. Analysis of the nature of the insulin resistance in those disorders has been investigated in intact subjects with the use of the euglycemic glucose clamp technique, and both insulin receptors and insulin-mediated glucose metabolism have been studied in adipocytes and monocytes from affected individuals. In both conditions, the cause of insulin resistance is heterogeneous. In some, insulin resistance appears to be due to a defect in the insulin receptor, whereas others have a defect both in the receptor and at the postreceptor level. In both groups, more severe insulin resistance is due to the postreceptor lesion and is correctable with appropriate therapy.

scholarly journals SEVERE INSULIN RESISTANCE DUE TO C.576C>G (P.I119M) MUTATION IN THE INSR GENE: CASE REPORT

2017 ◽  
Vol 3 (1) ◽  
pp. e17-e21
Author(s):  
Raya A. Almazrouei ◽  
Juma Alkaabi ◽  
Fatima M. Alkaabi ◽  
Hanan Alshamsi
Keyword(s):  
Insulin Resistance ◽  
Case Report ◽  
Severe Insulin Resistance ◽  
Insr Gene
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