Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer

10.1038/ng747 ◽  
2001 ◽  
Vol 29 (4) ◽  
pp. 418-425 ◽  
Author(s):  
Jos Jonkers ◽  
Ralph Meuwissen ◽  
Hanneke van der Gulden ◽  
Hans Peterse ◽  
Martin van der Valk ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Mouse Model ◽  
Suppressor Activity ◽  
Tumor Suppressor Activity ◽  
Conditional Mouse Model

scholarly journals Tumor Suppressor Activity of Klotho in Breast Cancer Is Revealed by Structure–Function Analysis

2015 ◽  
Vol 13 (10) ◽  
pp. 1398-1407 ◽  
Author(s):  
Hagai Ligumsky ◽  
Tami Rubinek ◽  
Keren Merenbakh-Lamin ◽  
Adva Yeheskel ◽  
Rotem Sertchook ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Structure Function ◽  
Function Analysis ◽  
Suppressor Activity ◽  
Tumor Suppressor Activity

scholarly journals Tumor-suppressor activity of RRIG1 in breast cancer

BMC Cancer ◽  
2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Guihong Zhang ◽  
Abenaa Brewster ◽  
Baoxiang Guan ◽  
Zhen Fan ◽  
Powel H Brown ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Suppressor Activity ◽  
Tumor Suppressor Activity

scholarly journals The Tumor Suppressor Activity of the Lysyl Oxidase Propeptide Reverses the Invasive Phenotype of Her-2/neu–Driven Breast Cancer

2007 ◽  
Vol 67 (3) ◽  
pp. 1105-1112 ◽  
Author(s):  
Chengyin Min ◽  
Kathrin H. Kirsch ◽  
Yingshe Zhao ◽  
Sébastien Jeay ◽  
Amitha H. Palamakumbura ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Lysyl Oxidase ◽  
Suppressor Activity ◽  
Invasive Phenotype ◽  
Tumor Suppressor Activity ◽  
Her 2 ◽  
Lysyl Oxidase Propeptide

scholarly journals Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Nathan F. Schachter ◽  
Jessica R. Adams ◽  
Patryk Skowron ◽  
Katelyn. J. Kozma ◽  
Christian A. Lee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Cooperative Networks ◽  
Loss Of Function ◽  
Suppressor Activity ◽  
Cancer Pathways ◽  
Chromosome Arm ◽  
Tumor Suppressor Activity ◽  
Single Allele ◽  
Genomic Regions

AbstractThe most common events in breast cancer (BC) involve chromosome arm losses and gains. Here we describe identification of 1089 gene-centric common insertion sites (gCIS) from transposon-based screens in 8 mouse models of BC. Some gCIS are driver-specific, others driver non-specific, and still others associated with tumor histology. Processes affected by driver-specific and histology-specific mutations include well-known cancer pathways. Driver non-specific gCIS target the Mediator complex, Ca++ signaling, Cyclin D turnover, RNA-metabolism among other processes. Most gCIS show single allele disruption and many map to genomic regions showing high-frequency hemizygous loss in human BC. Two gCIS, Nf1 and Trps1, show synthetic haploinsufficient tumor suppressor activity. Many gCIS act on the same pathway responsible for tumor initiation, thereby selecting and sculpting just enough and just right signaling. These data highlight ~1000 genes with predicted conditional haploinsufficient tumor suppressor function and the potential to promote chromosome arm loss in BC.

Targeting the p53 tumor suppressor activity in glioblastomas using small molecule MDM2-inhibitor

2011 ◽  
Vol 42 (01) ◽  
Author(s):  
P. Monfared ◽  
T. Viel ◽  
G. Schneider ◽  
Y. Waerzeggers ◽  
S. Rapic ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Small Molecule ◽  
Suppressor Activity ◽  
P53 Tumor Suppressor ◽  
Tumor Suppressor Activity ◽  
Mdm2 Inhibitor
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