Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis

2005 ◽  
Vol 37 (9) ◽  
pp. 964-968 ◽  
Author(s):  
Olivier Gribouval ◽  
Marie Gonzales ◽  
Thomas Neuhaus ◽  
Jacqueline Aziza ◽  
Eric Bieth ◽  
...  
Keyword(s):  
Autosomal Recessive ◽  
Renin Angiotensin System ◽  
Renal Tubular Dysgenesis ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Renal Tubular

Spectrum of mutations in the renin-angiotensin system genes in autosomal recessive renal tubular dysgenesis

2011 ◽  
Vol 33 (2) ◽  
pp. 316-326 ◽  
Author(s):  
Olivier Gribouval ◽  
Vincent Morinière ◽  
Audrey Pawtowski ◽  
Christelle Arrondel ◽  
Satu-Leena Sallinen ◽  
...  
Keyword(s):  
Autosomal Recessive ◽  
Renin Angiotensin System ◽  
Renal Tubular Dysgenesis ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Renal Tubular

Renal tubular dysgenesis

2015 ◽  
Author(s):  
Michiel F. Schreuder
Keyword(s):  
Renin Angiotensin System ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Genetic Mutation ◽  
Recessive Trait ◽  
Angiotensin Ii Receptor ◽  
Renal Tubular Dysgenesis ◽  
Converting Enzyme Inhibitors ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Renal Tubular

Renal tubular dysgenesis involves the absence or incomplete differentiation of proximal tubular nephron segments. Due to the lack of a patent nephron, it is characterized by (fetal) anuria and subsequent oligohydramnios, pulmonary hypoplasia, premature birth with severe and refractory arterial hypotension, and fetal or neonatal death. The main cause for renal tubular dysgenesis is a genetic mutation in the renin–angiotensin system, which has shown an autosomal recessive trait. Maternal use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers during pregnancy can have similar blocking effects on the fetal renin–angiotensin system, which may lead to renal tubular dysgenesis. Even though there is no actual renal function, ultrasound usually shows kidneys of normal size and architecture with an intact corticomedullary differentiation. Most patients with renal tubular dysgenesis do not survive beyond the neonatal period. A few patients have been described to survive with respiratory support, vasopressor treatment, and dialysis.

Resveratrol ameliorates the cyclosporine-induced vascular and renal impairments: possible impact of the modulation of renin–angiotensin system

2019 ◽  
Vol 97 (12) ◽  
pp. 1115-1123 ◽  
Author(s):  
Seldag Bekpinar ◽  
Ece Karaca ◽  
Selin Yamakoğlu ◽  
F. İlkay Alp-Yıldırım ◽  
Vakur Olgac ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Angiotensin Converting Enzyme ◽  
Renin Angiotensin System ◽  
Immunosuppressive Drug ◽  
Oxidative Stress Marker ◽  
Converting Enzyme ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
System Components ◽  
Renal Tubular

Cyclosporine, an immunosuppressive drug, exhibits a toxic effect on renal and vascular systems. The present study investigated whether resveratrol treatment alleviates renal and vascular injury induced by cyclosporine. Cyclosporine (25 mg/kg per day, s.c.) was given for 7 days to rats either alone or in combination with resveratrol (10 mg/kg per day, i.p.). Relaxation and contraction responses of aorta were examined. Serum levels of blood urea nitrogen, creatinine, angiotensin II, and angiotensin 1-7 were measured. Histopathological examinations as well as immunostaining for 4-hydroxynonenal and nitrotyrosine were performed in the kidney. RNA expressions of renin–angiotensin system components were also measured in renal and aortic tissues. Cyclosporine decreased the endothelium-dependent relaxation and increased vascular contraction in the aorta. It caused renal tubular degeneration and increased immunostaining for 4-hydroxynonenal, an oxidative stress marker. Cyclosporine also caused upregulations of the vasoconstrictive renin–angiotensin system components in renal (angiotensin-converting enzyme) and aortic (angiotensin II type 1 receptor) tissues. Resveratrol co-treatment prevented the cyclosporine-related deteriorations. Moreover, it induced the expressions of vasodilatory effective angiotensin-converting enzyme 2 and angiotensin II type 2 receptor in aorta and kidney, respectively. We conclude that resveratrol may be effective in preventing cyclosporine-induced renal tubular degeneration and vascular dysfunction at least in part by modulating the renin–angiotensin system.

RENAL TUBULAR RENIN-ANGIOTENSIN SYSTEM AS A MAJOR DETERMINANT OF BLOOD PRESSURE IN LOW RENIN HYPERTENSIVE WOMEN

2004 ◽  
Vol 22 (Suppl. 2) ◽  
pp. S43
Author(s):  
P. Lantelme ◽  
A. Rohrwasser ◽  
M. Vincent ◽  
M. O. Rial ◽  
L. Legedz ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renin Angiotensin System ◽  
Major Determinant ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Renal Tubular
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