scholarly journals PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans

2010 ◽  
Vol 42 (10) ◽  
pp. 859-863 ◽  
Author(s):  
Ingrid L Berg ◽  
Rita Neumann ◽  
Kwan-Wood G Lam ◽  
Shriparna Sarbajna ◽  
Linda Odenthal-Hesse ◽  
...  
Keyword(s):  
Hot Spot ◽  
Spot Activity ◽  
Meiotic Instability

scholarly journals Analysis of the outer divertor hot spot activity in the protection video camera recordings at JET

2019 ◽  
Vol 139 ◽  
pp. 115-123
Author(s):  
A. Drenik ◽  
S. Brezinsek ◽  
P. Carvalho ◽  
V. Huber ◽  
N. Osterman ◽  
...  
Keyword(s):  
Hot Spot ◽  
Video Camera ◽  
Spot Activity

Origin of the lithospheric tension causing basin formation

1982 ◽  
Vol 305 (1489) ◽  
pp. 319-324 ◽  
Keyword(s):  
Hot Spot ◽  
Plate Boundary ◽  
High Heat ◽  
Continental Lithosphere ◽  
Normal Faulting ◽  
High Heat Flow ◽  
Elastic Part ◽  
Early Mesozoic ◽  
Spot Activity ◽  
Basin Formation

Most fault-controlled basin formation within plate interiors occurs by normal faulting in response to horizontal deviatoric tension in the continental crust. It is suggested that the tension originates either from the plate boundary forces acting at trenches or as a result of isostatically compensated uplifted regions such as East Africa. The tension produced by both mechanisms is greatest in high heat-flow regions where the upper elastic part of the lithosphere is thinned and weakened. Particularly widespread tension in the continental lithosphere occurs when subduction takes place on opposite sides of a large continental mass, such as Pangaea in the early Mesozoic, where it led to widespread graben formation and, in association with hot spot activity, to continental splitting.

Rec-mediated recombinational hot spot activity in bacteriophage λ

1975 ◽  
Vol 140 (1) ◽  
pp. 29-37 ◽  
Author(s):  
Franklin W. Stahl ◽  
Mary M. Stahl
Keyword(s):  
Hot Spot ◽  
Bacteriophage Λ ◽  
Spot Activity

Hot spot activity and the break-up of Pangea

2000 ◽  
Vol 161 (1-2) ◽  
pp. 49-69 ◽  
Author(s):  
Jan Golonka ◽  
Natalia Yurevna Bocharova
Keyword(s):  
Hot Spot ◽  
Spot Activity ◽  
Break Up

scholarly journals REC-MEDIATED RECOMBINATIONAL HOT SPOT ACTIVITY IN BACTERIOPHAGE LAMBDA. I. HOT SPOT ACTIVITY ASSOCIATED WITH SPI-DELETIONS AND bio SUBSTITUTIONS

Genetics ◽  
1974 ◽  
Vol 77 (3) ◽  
pp. 409-423
Author(s):  
Kenneth D McMilin ◽  
Mary M Stahl ◽  
Franklin W Stahl
Keyword(s):  
Dna Synthesis ◽  
Genetic Marker ◽  
Density Gradient ◽  
Hot Spot ◽  
The Other ◽  
Bacteriophage Λ ◽  
Chromosomal Distribution ◽  
Recombinant Phage ◽  
Spot Activity ◽  
The Right

ABSTRACT In order to survey the distribution along the bacteriophage λ chromosome of Rec-mediated recombination events, crosses are performed using conditions which block essentially all DNA synthesis. One parent is density-labeled and carries a genetic marker in the left terminal λ gene (A), while the other parent is unlabeled and carries a genetic marker in the right terminal λ gene (R). Both parents are deleted for the λ recombination genes int and red, together with other recombination-associated genes, by virtue of either (1) a pure deletion or (2) a bio insertion-deletion. The distribution in a cesium density gradient of the resulting A+R+ recombinant phage reflects the chromosomal distribution of the recombination events which gave rise to those phage.

scholarly journals Control of Meiotic Recombination and Gene Expression in Yeast by a Simple Repetitive DNA Sequence That Excludes Nucleosomes

1999 ◽  
Vol 19 (11) ◽  
pp. 7661-7671 ◽  
Author(s):  
David T. Kirkpatrick ◽  
Yuh-Hwa Wang ◽  
Margaret Dominska ◽  
Jack D. Griffith ◽  
Thomas D. Petes
Keyword(s):  
Meiotic Recombination ◽  
Tandem Repeats ◽  
Hot Spot ◽  
Cold Spot ◽  
Regulatory Sequences ◽  
Spot Activity ◽  
In Vivo Effects ◽  
Upstream Regulatory Sequences

ABSTRACT Tandem repeats of the pentanucleotide 5′-CCGNN (where N indicates any base) were previously shown to exclude nucleosomes in vitro (Y.-H. Wang and J. D. Griffith, Proc. Natl. Acad. Sci. USA 93:8863–8867, 1996). To determine the in vivo effects of these sequences, we replaced the upstream regulatory sequences of the HIS4 gene ofSaccharomyces cerevisiae with either 12 or 48 tandem copies of CCGNN. Both tracts activated HIS4 transcription. We found that (CCGNN)12 tracts elevated meiotic recombination (hot spot activity), whereas the (CCGNN)48 tract repressed recombination (cold spot activity). In addition, a “pure” tract of (CCGAT)12 activated both transcription and meiotic recombination. We suggest that the cold spot activity of the (CCGNN)48 tract is related to the phenomenon of the suppressive interactions of adjacent hot spots previously described in yeast (Q.-Q. Fan, F. Xu, and T. D. Petes, Mol. Cell. Biol. 15:1679–1688, 1995; Q.-Q. Fan, F. Xu, M. A. White, and T. D. Petes, Genetics 145:661–670, 1997; T.-C. Wu and M. Lichten, Genetics 140:55–66, 1995; L. Xu and N. Kleckner, EMBO J. 16:5115–5128, 1995).

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