scholarly journals A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33

2010 ◽  
Vol 42 (3) ◽  
pp. 224-228 ◽  
Author(s):  
Gloria M Petersen ◽  
Laufey Amundadottir ◽  
Charles S Fuchs ◽  
Peter Kraft ◽  
Rachael Z Stolzenberg-Solomon ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Cancer Susceptibility ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Genome Wide ◽  
A Genome

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3

2008 ◽  
Vol 40 (5) ◽  
pp. 623-630 ◽  
Author(s):  
Ian PM Tomlinson ◽  
◽  
Emily Webb ◽  
Luis Carvajal-Carmona ◽  
Peter Broderick ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Cancer Susceptibility ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Genome Wide ◽  
A Genome

scholarly journals Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

2009 ◽  
Vol 41 (10) ◽  
pp. 1116-1121 ◽  
Author(s):  
Rosalind A Eeles ◽  
◽  
Zsofia Kote-Jarai ◽  
Ali Amin Al Olama ◽  
Graham G Giles ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Cancer Susceptibility ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Prostate Cancer Susceptibility ◽  
Genome Wide ◽  
A Genome

A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12

2013 ◽  
Vol 45 (8) ◽  
pp. 918-922 ◽  
Author(s):  
Yongyong Shi ◽  
Li Li ◽  
Zhibin Hu ◽  
Shuang Li ◽  
Shixuan Wang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Cancer Susceptibility ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Genome Wide ◽  
A Genome

scholarly journals Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

2019 ◽  
Author(s):  
Haoyu Zhang ◽  
Thomas U. Ahearn ◽  
Julie Lecarpentier ◽  
Daniel Barnes ◽  
Jonathan Beesley ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Genome Wide Association ◽  
European Ancestry ◽  
Susceptibility Loci ◽  
Genome Wide ◽  
A Genome

AbstractBreast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype. To identify novel loci, we performed a genome-wide association study (GWAS) including 133,384 breast cancer cases and 113,789 controls, plus 18,908 BRCA1 mutation carriers (9,414 with breast cancer) of European ancestry, using both standard and novel methodologies that account for underlying tumor heterogeneity by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status and tumor grade. We identified 32 novel susceptibility loci (P<5.0×10-8), 15 of which showed evidence for associations with at least one tumor feature (false discovery rate <0.05). Five loci showed associations (P<0.05) in opposite directions between luminal- and non-luminal subtypes. In-silico analyses showed these five loci contained cell-specific enhancers that differed between normal luminal and basal mammary cells. The genetic correlations between five intrinsic-like subtypes ranged from 0.35 to 0.80. The proportion of genome-wide chip heritability explained by all known susceptibility loci was 37.6% for triple-negative and 54.2% for luminal A-like disease. These findings provide an improved understanding of genetic predisposition to breast cancer subtypes and will inform the development of subtype-specific polygenic risk scores.

scholarly journals A Genome-Wide Association Study in Early COPD: Identification of One Major Susceptibility Loci

2020 ◽  
Vol Volume 15 ◽  
pp. 2967-2975
Author(s):  
Ye-Jin Lee ◽  
SeungHo Choi ◽  
Sung-Youn Kwon ◽  
Yunhwan Lee ◽  
Jung Kyu Lee ◽  
...  
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Genome Wide ◽  
A Genome
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