scholarly journals Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor

2017 ◽  
Vol 49 (7) ◽  
pp. 1141-1147 ◽  
Author(s):  
Zhaoming Wang ◽  
◽  
Katherine A McGlynn ◽  
Ewa Rajpert-De Meyts ◽  
D Timothy Bishop ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Association Studies ◽  
Meta Analysis ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Testicular Germ Cell ◽  
Genome Wide

scholarly journals A genome-wide association study of testicular germ cell tumor

2009 ◽  
Vol 41 (7) ◽  
pp. 807-810 ◽  
Author(s):  
Elizabeth A Rapley ◽  
◽  
Clare Turnbull ◽  
Ali Amin Al Olama ◽  
Emmanouil T Dermitzakis ◽  
...  
Keyword(s):  
Germ Cell ◽  
Association Study ◽  
Germ Cell Tumor ◽  
Genome Wide Association Study ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Genome Wide Association ◽  
Testicular Germ Cell ◽  
Genome Wide ◽  
A Genome

scholarly journals Meta-Analysis of Gene Expressions in Testicular Germ Cell Tumor Histologies

2020 ◽  
Vol 21 (12) ◽  
pp. 4487
Author(s):  
Finn Edler von Eyben ◽  
Jorge Parraga-Alava
Keyword(s):  
Germ Cell ◽  
Candidate Genes ◽  
Germ Cell Tumor ◽  
Meta Analysis ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Rna Expression ◽  
Tumor Type ◽  
Testicular Germ Cell ◽  
Histologic Types

There is no consensus as to how a precursor lesion, germ cell neoplasia in situ (GCNIS), develops into the histologic types of testicular germ cell tumor type II (TGCT). The present meta-analysis examined RNA expressions of 24 candidate genes in three datasets. They included 203 samples of normal testis (NT) and histologic types of TGCT. The Fisher’s test for combined p values was used for meta-analysis of the RNA expressions in the three datasets. The histologic types differed in RNA expression of PRAME, KIT, SOX17, NANOG, KLF4, POU5F1, RB1, DNMT3B, and LIN28A (p < 0.01). The histologic types had concordant differences in RNA expression of the genes in the three datasets. Eight genes had overlap with a high RNA expression in at least two histologic types. In contrast, only seminoma (SE) had a high RNA expression of KLF4 and only embryonal carcinoma (EC) had a high RNA expression of DNMT3B. In conclusion, the meta-analysis showed that the development of the histologic types of TGCT was driven by changes in RNA expression of candidate genes. According to the RNA expressions of the ten genes, TGCT develops from NT over GCNIS, SE, EC, to the differentiated types of TGCT.

scholarly journals Meta-analysis identifies four new loci associated with testicular germ cell tumor

2013 ◽  
Vol 45 (6) ◽  
pp. 680-685 ◽  
Author(s):  
Charles C Chung ◽  
Peter A Kanetsky ◽  
Zhaoming Wang ◽  
Michelle A T Hildebrandt ◽  
Roelof Koster ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Meta Analysis ◽  
Testicular Germ Cell Tumor ◽  
Cell Tumor ◽  
Testicular Germ Cell
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