DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader

Jeremy M Rock; Ulla F Lang; Michael R Chase; Christopher B Ford; Elias R Gerrick; Richa Gawande; Mireia Coscolla; Sebastien Gagneux; Sarah M Fortune; Meindert H Lamers

doi:10.1038/ng.3269

DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader

Nature Genetics ◽

10.1038/ng.3269 ◽

2015 ◽

Vol 47 (6) ◽

pp. 677-681 ◽

Cited By ~ 37

Author(s):

Jeremy M Rock ◽

Ulla F Lang ◽

Michael R Chase ◽

Christopher B Ford ◽

Elias R Gerrick ◽

...

Keyword(s):

Mycobacterium Tuberculosis ◽

Dna Replication ◽

Replication Fidelity ◽

Dna Replication Fidelity

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DNA Replication Fidelity in the Mycobacterium tuberculosis Complex

Advances in Experimental Medicine and Biology - Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control ◽

10.1007/978-3-319-64371-7_13 ◽

2017 ◽

pp. 247-262 ◽

Cited By ~ 5

Author(s):

Digby F. Warner ◽

Jeremy M. Rock ◽

Sarah M. Fortune ◽

Valerie Mizrahi

Keyword(s):

Mycobacterium Tuberculosis ◽

Dna Replication ◽

Mycobacterium Tuberculosis Complex ◽

Tuberculosis Complex ◽

Replication Fidelity ◽

Dna Replication Fidelity

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Faculty Opinions recommendation of Reduction of dNTP levels enhances DNA replication fidelity in vivo.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717985983.793472231 ◽

2013 ◽

Author(s):

Martin Marinus

Keyword(s):

Dna Replication ◽

Replication Fidelity ◽

Dna Replication Fidelity

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DNA-replication fidelity, mismatch repair and genome instability in cancer cells

EJB Reviews 1996 ◽

10.1007/978-3-642-60659-5_9 ◽

1996 ◽

pp. 163-173 ◽

Cited By ~ 1

Author(s):

Asad Umar ◽

Thomas A. Kunkel

Keyword(s):

Dna Replication ◽

Cancer Cells ◽

Mismatch Repair ◽

Genome Instability ◽

Replication Fidelity ◽

Dna Replication Fidelity

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Reduction of dNTP levels enhances DNA replication fidelity in vivo

DNA Repair ◽

10.1016/j.dnarep.2013.01.009 ◽

2013 ◽

Vol 12 (4) ◽

pp. 300-305 ◽

Cited By ~ 10

Author(s):

Luisa Laureti ◽

Marjorie Selva ◽

Julien Dairou ◽

Ivan Matic

Keyword(s):

Dna Replication ◽

Replication Fidelity ◽

Dna Replication Fidelity

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Role of Watson-Crick-Like Mismatches in DNA Replication Fidelity

Biophysical Journal ◽

10.1016/j.bpj.2016.11.419 ◽

2017 ◽

Vol 112 (3) ◽

pp. 70a

Author(s):

Eric S. Szymanski ◽

Isaac J. Kimsey ◽

Hashim M. Al-Hashimi

Keyword(s):

Dna Replication ◽

Replication Fidelity ◽

Dna Replication Fidelity

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DNA replication fidelity and cancer

Seminars in Cancer Biology ◽

10.1016/j.semcancer.2010.10.009 ◽

2010 ◽

Vol 20 (5) ◽

pp. 281-293 ◽

Cited By ~ 90

Author(s):

Bradley D. Preston ◽

Tina M. Albertson ◽

Alan J. Herr

Keyword(s):

Dna Replication ◽

Replication Fidelity ◽

Dna Replication Fidelity

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A quantitative, non-radioactive single-nucleotide insertion assay for analysis of DNA replication fidelity by using an automated DNA sequencer

Biotechnology Letters ◽

10.1023/b:bile.0000030047.32578.82 ◽

2004 ◽

Vol 26 (12) ◽

pp. 999-1005 ◽

Cited By ~ 7

Author(s):

Michiko Kimoto ◽

Shigeyuki Yokoyama ◽

Ichiro Hirao

Keyword(s):

Dna Replication ◽

Single Nucleotide ◽

Replication Fidelity ◽

Nucleotide Insertion ◽

Dna Replication Fidelity ◽

Dna Sequencer

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The Enhanced DNA Replication Fidelity of a Mutant Herpes Simplex Virus Type 1 DNA Polymerase Is Mediated by an Improved Nucleotide Selectivity and Reduced Mismatch Extension Ability

Journal of Virology ◽

10.1128/jvi.00911-08 ◽

2008 ◽

Vol 82 (17) ◽

pp. 8937-8941 ◽

Cited By ~ 7

Author(s):

Wang Tian ◽

Ying T. Hwang ◽

Charles B. C. Hwang

Keyword(s):

Herpes Simplex Virus ◽

Dna Replication ◽

Herpes Simplex ◽

Dna Polymerase ◽

Herpes Simplex Virus Type ◽

Wild Type ◽

Replication Fidelity ◽

Simplex Virus ◽

Dna Replication Fidelity

ABSTRACT We previously demonstrated that a recombinant herpes simplex virus containing a mutation within the finger domain of DNA polymerase replicated DNA with increased fidelity. In this study, we demonstrate that, compared with wild-type polymerase, the mutant enzyme exhibited improved nucleotide selectivity and a reduced ability to extend from mismatched primer termini, which would contribute to the increased DNA replication fidelity.

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