scholarly journals Understanding multicellular function and disease with human tissue-specific networks

2015 ◽  
Vol 47 (6) ◽  
pp. 569-576 ◽  
Author(s):  
Casey S Greene ◽  
Arjun Krishnan ◽  
Aaron K Wong ◽  
Emanuela Ricciotti ◽  
Rene A Zelaya ◽  
...  
Keyword(s):  
Human Tissue ◽  
Tissue Specific

Tissue specific expression and serum levels of human tissue factor in patients with urological cancer

2003 ◽  
Vol 193 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Yvonne Förster ◽  
Axel Meye ◽  
Sybille Albrecht ◽  
Matthias Kotzsch ◽  
Susanne Füssel ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Human Tissue ◽  
Serum Levels ◽  
Urological Cancer ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression

scholarly journals TissueCoCoPUTs: Novel Human Tissue-Specific Codon and Codon-Pair Usage Tables Based on Differential Tissue Gene Expression

2020 ◽  
Vol 432 (11) ◽  
pp. 3369-3378 ◽  
Author(s):  
Jacob Kames ◽  
Aikaterini Alexaki ◽  
David D. Holcomb ◽  
Luis V. Santana-Quintero ◽  
John C. Athey ◽  
...  
Keyword(s):  
Gene Expression ◽  
Human Tissue ◽  
Tissue Specific ◽  
Codon Pair ◽  
Differential Tissue ◽  
Tissue Gene Expression

scholarly journals Biclustering of transcriptome sequencing data reveals human tissue-specific circular RNAs

BMC Genomics ◽  
2018 ◽  
Vol 19 (S1) ◽  
Author(s):  
Yu-Chen Liu ◽  
Yu-Jung Chiu ◽  
Jian-Rong Li ◽  
Chuan-Hu Sun ◽  
Chun-Chi Liu ◽  
...  
Keyword(s):  
Human Tissue ◽  
Transcriptome Sequencing ◽  
Circular Rnas ◽  
Sequencing Data ◽  
Tissue Specific

scholarly journals Scope and limitations of yeast as a model organism for studying human tissue-specific pathways

2015 ◽  
Vol 9 (1) ◽  
Author(s):  
Shahin Mohammadi ◽  
Baharak Saberidokht ◽  
Shankar Subramaniam ◽  
Ananth Grama
Keyword(s):  
Human Tissue ◽  
Model Organism ◽  
Tissue Specific

scholarly journals Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

2013 ◽  
Vol 13 (2) ◽  
pp. 397-406 ◽  
Author(s):  
Linn Fagerberg ◽  
Björn M. Hallström ◽  
Per Oksvold ◽  
Caroline Kampf ◽  
Dijana Djureinovic ◽  
...  
Keyword(s):  
Human Tissue ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression ◽  
Genome Wide

scholarly journals A convex optimization approach for identification of human tissue-specific interactomes

2016 ◽  
Author(s):  
Shahin Mohammadi ◽  
Ananth Grama
Keyword(s):  
Human Tissue ◽  
Drug Targets ◽  
Protein Complexes ◽  
Disease Genes ◽  
Optimization Approach ◽  
Cell Type Specificity ◽  
Tissue Specific ◽  
Parkinson’S Diseases ◽  
Coordinated Expression ◽  
Validation Tests

AbstractMotivation:Analysis of organism-specific interactomes has yielded novel insights into cellular function and coordination, understanding of pathology, and identification of markers and drug targets. Genes, however, can exhibit varying levels of cell-type specificity in their expression, and their coordinated expression manifests in tissue-specific function and pathology. Tissue-specific/ selective interaction mechanisms have significant applications in drug discovery, as they are more likely to reveal drug targets. Furthermore, tissue-specific transcription factors (tsTFs) are significantly implicated in human disease, including cancers. Finally, disease genes and protein complexes have the tendency to be differentially expressed in tissues in which defects cause pathology. These observations motivate the construction of refined tissue-specific interactomes from organism-specific interactomes.Results:We present a novel technique for constructing human tissue-specific interactomes. Using a variety of validation tests (ESEA, GO Enrichment, Disease-Gene Subnetwork Compactness), we show that our proposed approach significantly outperforms state of the art techniques. Finally, using case studies of Alzheimer’s and Parkinson’s diseases, we show that tissue-specific interactomes derived from our study can be used to construct pathways implicated in pathology and demonstrate the use of these pathways in identifying novel targets.Availability:http://www.cs.purdue.edu/homes/mohammas/projects/ActPro.html

scholarly journals Study of Codon Usage Bias Between Genes of SARS-CoV-2 and Human Tissue-specific Genes

2021 ◽  
Vol 3 (3) ◽  
pp. 35-40
Author(s):  
Liheng Lai ◽  
Junqi Zhang ◽  
Zeyu Chen ◽  
Chonghe Sun ◽  
Yipeng Zhang
Keyword(s):  
Codon Usage ◽  
Human Tissue ◽  
Codon Usage Bias ◽  
Tissue Specific

Cloning, expression and characterization of human tissue-specific DNA polymerase λ2

2007 ◽  
Vol 50 (4) ◽  
pp. 457-465 ◽  
Author(s):  
Fu Gu ◽  
Chun You ◽  
JianPing Liu ◽  
Ao Chen ◽  
Yao Yu ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Human Tissue ◽  
Tissue Specific

scholarly journals Computational Detection and Functional Analysis of Human Tissue-Specific A-to-I RNA Editing

PLoS ONE ◽  
2011 ◽  
Vol 6 (3) ◽  
pp. e18129 ◽  
Author(s):  
Tao He ◽  
Qiong Wang ◽  
Guihai Feng ◽  
Yaou Hu ◽  
Li Wang ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Rna Editing ◽  
Human Tissue ◽  
Tissue Specific
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