scholarly journals Enhancer evolution in mammals

2015 ◽  
Vol 47 (3) ◽  
pp. 198-198
Author(s):  
Tiago Faial
Keyword(s):  
Enhancer Evolution

scholarly journals Independent transposon exaptation is a widespread mechanism of shadow enhancer evolution in the mammalian genome

2019 ◽  
Author(s):  
Nicolai K. H. Barth ◽  
Lifei Li ◽  
Leila Taher
Keyword(s):  
Convergent Evolution ◽  
Regulatory Networks ◽  
Tissue Specificity ◽  
Regulatory Elements ◽  
Mammalian Genome ◽  
Alternative Mechanism ◽  
Human And Mouse ◽  
Enhancer Evolution

ABSTRACTMany regulatory networks involve (possibly partially) redundant cis-regulatory elements. These elements are commonly referred to as shadow enhancers and have been assumed to mainly originate by sequence duplication. An alternative mechanism that has not been examined involves the independent exaptation of transposons. Here, we identified 2,117 and 2,787 pairs of shadow enhancers in the human and mouse genomes, respectively, and found that 34% and 18% of these pairs derive from transposons. Moreover, we show that virtually all the enhancer partners of these transposon-derived shadow enhancer pairs are independent exaptations from different transposon types and hypothesize that the increase in the expression and tissue-specificity of their targets as compared to those of non-shadow enhancers facilitates their fixation in the genome. Finally, we provide evidence that the regulatory redundancy observed in many mammalian regulatory networks is predominantly driven by convergent evolution, since shadow enhancers are hardly ever conserved across species.

scholarly journals Simulations of Enhancer Evolution Provide Mechanistic Insights into Gene Regulation

2013 ◽  
Vol 31 (1) ◽  
pp. 184-200 ◽  
Author(s):  
Thyago Duque ◽  
Md. Abul Hassan Samee ◽  
Majid Kazemian ◽  
Hannah N. Pham ◽  
Michael H. Brodsky ◽  
...  
Keyword(s):  
Gene Regulation ◽  
Enhancer Evolution

scholarly journals Functional characterization of enhancer evolution in the primate lineage

2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Jason C. Klein ◽  
Aidan Keith ◽  
Vikram Agarwal ◽  
Timothy Durham ◽  
Jay Shendure
Keyword(s):  
Functional Characterization ◽  
Primate Lineage ◽  
Enhancer Evolution

scholarly journals Enhancer Evolution across 20 Mammalian Species

Cell ◽  
2015 ◽  
Vol 160 (3) ◽  
pp. 554-566 ◽  
Author(s):  
Diego Villar ◽  
Camille Berthelot ◽  
Sarah Aldridge ◽  
Tim F. Rayner ◽  
Margus Lukk ◽  
...  
Keyword(s):  
Mammalian Species ◽  
Enhancer Evolution

scholarly journals Gene Regulation: Piecing Together the Puzzle of Enhancer Evolution

2011 ◽  
Vol 21 (14) ◽  
pp. R542-R543 ◽  
Author(s):  
Rhea R. Datta ◽  
Stephen Small
Keyword(s):  
Gene Regulation ◽  
Enhancer Evolution

scholarly journals Dissecting the regulatory switches of development: lessons from enhancer evolution in Drosophila

Development ◽  
2009 ◽  
Vol 137 (1) ◽  
pp. 5-13 ◽  
Author(s):  
M. J. Borok ◽  
D. A. Tran ◽  
M. C. W. Ho ◽  
R. A. Drewell
Keyword(s):  
Enhancer Evolution
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