scholarly journals Genome-wide association studies identify four ER negative–specific breast cancer risk loci

2013 ◽  
Vol 45 (4) ◽  
pp. 392-398 ◽  
Author(s):  
Montserrat Garcia-Closas ◽  
◽  
Fergus J Couch ◽  
Sara Lindstrom ◽  
Kyriaki Michailidou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Wide

scholarly journals Identifying 31 novel breast cancer susceptibility loci using data from genome-wide association studies conducted in Asian and European women

2019 ◽  
Author(s):  
Xiang Shu ◽  
Jirong Long ◽  
Qiuyin Cai ◽  
Sun-Seog Kweon ◽  
Ji-Yeob Choi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Association Studies ◽  
Meta Analysis ◽  
Genome Wide Association Studies ◽  
Asian Populations ◽  
Risk Variants ◽  
Genome Wide ◽  
European Women

ABSTRACTCommon genetic variants in 183 loci have been identified in relation to breast cancer risk in genome-wide association studies (GWAS). These risk variants combined explain only a relatively small proportion of breast cancer heritability, particularly in Asian populations. To search for additional genetic susceptibility loci for breast cancer, we performed a meta-analysis of data from GWAS conducted in Asians (24,206 cases and 24,775 controls). Variants showing an association with breast cancer risk at P < 0.01 were evaluated in GWAS conducted in European women including 122,977 cases and 105,974 controls. In the combined analysis of data from both Asian and European women, the lead variant in 28 loci not previously reported showed an association with breast cancer risk at P < 5 ×10−8. In the meta-analysis of all GWAS data from Asian and European descendants, we identified SNPs in three additional loci in association with breast cancer risk at P < 5 ×10−8. The associations for 10 of these loci were replicated in an independent sample of 16,787 cases and 16,680 controls of Asian women (P < 0.05). Expression quantitative trait locus (eQTL) and gene-based analyses provided evidence for the possible involvement of the YBEY, MAN2C1, SNUPN, TBX1, SEMA4A, STC1, MUTYH, LOXL2, and LINC00886 genes underlying the associations observed in eight of these 28 newly identified risk loci. In addition, we replicated the association for 78 of the 166 previously reported risk variants at P < 0.05 in women of Asian descent using GWAS data. These findings improve our understanding of breast cancer genetics and etiology and extend to Asian populations previous findings from studies of European women.

scholarly journals Fine mapping of breast cancer genome-wide association studies loci in women of African ancestry identifies novel susceptibility markers

2013 ◽  
Vol 34 (7) ◽  
pp. 1520-1528 ◽  
Author(s):  
Y. Zheng ◽  
T. O. Ogundiran ◽  
A. G. Falusi ◽  
K. L. Nathanson ◽  
E. M. John ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fine Mapping ◽  
Association Studies ◽  
African Ancestry ◽  
Cancer Genome ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Wide
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