A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk

2007 ◽  
Vol 39 (11) ◽  
pp. 1315-1317 ◽  
Author(s):  
Peter Broderick ◽  
◽  
Luis Carvajal-Carmona ◽  
Alan M Pittman ◽  
Emily Webb ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Colorectal Cancer Risk ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals Genetic Risk Factors for Colorectal Cancer in Multiethnic Indonesians

2019 ◽  
Author(s):  
Irawan Yusuf ◽  
Upik A. Miskad ◽  
Ronald E. Lusikooy ◽  
Arham Arsyad ◽  
Akram Irwan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Cancer Risk ◽  
Genome Wide Association Study ◽  
Risk Model ◽  
Bayesian Variable Selection ◽  
Colorectal Cancer Risk ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

AbstractPurposeColorectal cancer is a common cancer in Indonesia, yet it has been understudied. We conduct a genome-wide association study focused on evaluation and discovery of colorectal cancer risk factors in Indonesians.MethodsWe administered detailed questionnaires and collecting blood samples from 162 colorectal cancer cases throughout Makassar, Indonesia. We also established a control set of 193 healthy individuals frequency matched by age, sex, and ethnicity. A genome-wide association analysis was performed on 84 cases and 89 controls passing quality control. We evaluated known colorectal cancer genetic variants using logistic regression and established a genome-wide polygenic risk model using a Bayesian variable selection technique.ResultsWe replicate associations for rs9497673, rs6936461 and rs7758229 on chromosome 6; rs11255841 on chromosome 10; and rs4779584, rs11632715, and rs73376930 on chromosome 15. Polygenic modeling identified 10 SNP associated with colorectal cancer risk.ConclusionsThis work helps characterize the relationship between variants in theSCL22A3,SCG5,GREM1, andSTXBP5-AS1genes and colorectal cancer in a diverse Indonesian population. With further biobanking and international research collaborations, variants specific to colorectal cancer risk in Indonesians will be identified.

scholarly journals A novel colorectal cancer risk locus at 4q32.2 identified from an international genome-wide association study

2014 ◽  
Vol 35 (11) ◽  
pp. 2512-2519 ◽  
Author(s):  
Stephanie L. Schmit ◽  
Fredrick R. Schumacher ◽  
Christopher K. Edlund ◽  
David V. Conti ◽  
Leon Raskin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Colorectal Cancer Risk ◽  
Genome Wide Association ◽  
Genome Wide ◽  
Risk Locus

scholarly journals A colorectal cancer genome-wide association study in a Spanish cohort identifies two variants associated with colorectal cancer risk at 1p33 and 8p12

BMC Genomics ◽  
2013 ◽  
Vol 14 (1) ◽  
pp. 55 ◽  
Author(s):  
Ceres Fernandez-Rozadilla ◽  
Jean-Baptiste Cazier ◽  
Ian P Tomlinson ◽  
Luis G Carvajal-Carmona ◽  
Claire Palles ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Cancer Genome ◽  
Colorectal Cancer Risk ◽  
Genome Wide Association ◽  
Genome Wide ◽  
Spanish Cohort

scholarly journals Genetic risk factors for colorectal cancer in multiethnic Indonesians

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Irawan Yusuf ◽  
Bens Pardamean ◽  
James W. Baurley ◽  
Arif Budiarto ◽  
Upik A. Miskad ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Cancer Risk ◽  
Genome Wide Association Study ◽  
Risk Model ◽  
Bayesian Variable Selection ◽  
Colorectal Cancer Risk ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

AbstractColorectal cancer is a common cancer in Indonesia, yet it has been understudied in this resource-constrained setting. We conducted a genome-wide association study focused on evaluation and preliminary discovery of colorectal cancer risk factors in Indonesians. We administered detailed questionnaires and collecting blood samples from 162 colorectal cancer cases throughout Makassar, Indonesia. We also established a control set of 193 healthy individuals frequency matched by age, sex, and ethnicity. A genome-wide association analysis was performed on 84 cases and 89 controls passing quality control. We evaluated known colorectal cancer genetic variants using logistic regression and established a genome-wide polygenic risk model using a Bayesian variable selection technique. We replicate associations for rs9497673, rs6936461 and rs7758229 on chromosome 6; rs11255841 on chromosome 10; and rs4779584, rs11632715, and rs73376930 on chromosome 15. Polygenic modeling identified 10 SNP associated with colorectal cancer risk. This work helps characterize the relationship between variants in the SCL22A3, SCG5, GREM1, and STXBP5-AS1 genes and colorectal cancer in a diverse Indonesian population. With further biobanking and international research collaborations, variants specific to colorectal cancer risk in Indonesians will be identified.

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