scholarly journals Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder

2011 ◽  
Vol 44 (1) ◽  
pp. 78-84 ◽  
Author(s):  
Josephine Elia ◽  
Joseph T Glessner ◽  
Kai Wang ◽  
Nagahide Takahashi ◽  
Corina J Shtir ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Copy Number ◽  
Gene Networks ◽  
Metabotropic Glutamate Receptor ◽  
Receptor Gene ◽  
Metabotropic Glutamate ◽  
Hyperactivity Disorder ◽  
Genome Wide ◽  
Number Variation

Genome-wide copy number variation analysis in adult attention-deficit and hyperactivity disorder

2014 ◽  
Vol 49 ◽  
pp. 60-67 ◽  
Author(s):  
Josep-Antoni Ramos-Quiroga ◽  
Cristina Sánchez-Mora ◽  
Miguel Casas ◽  
Iris Garcia-Martínez ◽  
Rosa Bosch ◽  
...  
Keyword(s):  
Copy Number Variation ◽  
Attention Deficit ◽  
Copy Number ◽  
Variation Analysis ◽  
Hyperactivity Disorder ◽  
Copy Number Variation Analysis ◽  
Genome Wide ◽  
Number Variation

scholarly journals DRD4 Gene Polymorphisms as a Risk Factor for Children with Attention Deficit Hyperactivity Disorder in Iranian Population

2017 ◽  
Vol 2017 ◽  
pp. 1-5
Author(s):  
Seyed Mahmoud Tabatabaei ◽  
Shahrokh Amiri ◽  
Sara Faghfouri ◽  
Seyed Gholamreza Noorazar ◽  
Shahin AbdollahiFakhim ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Tandem Repeats ◽  
Receptor Gene ◽  
Variable Number ◽  
Healthy Children ◽  
Drd4 Gene ◽  
Hyperactivity Disorder ◽  
Significant Difference ◽  
Northwest Of Iran

Background and Objective. Dopamine dysfunction is known to be associated with attention deficit hyperactivity disorder (ADHD). Dopamine D4 receptor gene (DRD4) is one of the important genes in this pathway. This study intended to investigate the variable number of tandem repeats (VNTR) in exon 3 of the DRD4 gene in Iranian children and adolescents. Materials and Methods. In this study, 130 children with ADHD, aged 6–14 years, and 130 healthy children, within the same age range, were enrolled. All children were selected from northwest of Iran which have Caucasian ethnic background and are of a Turkic ethnic group. VNTR polymorphisms of the DRD4 gene were evaluated by PCR using exon 3-specific primers followed by agarose gel electrophoresis. Findings. The Hardy-Weinberg principle and Chi-square test showed a significant difference in 4-repetition (4R) alleles between the ADHD (76.2%) and control (53.8%) groups (p=0.004; X2=17.39; df=5). The least percentage of repetition alleles in both groups was 2R. Conclusion. There is a significant correlation between the 4R alleles of DRD4 and ADHD in the northwest of Iran.

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