Active surveillance for low-risk prostate cancer: selection of patients and predictors of progression

2008 ◽  
Vol 5 (5) ◽  
pp. 277-283 ◽  
Author(s):  
Marc A Dall'Era ◽  
Badrinath R Konety
Keyword(s):  
Prostate Cancer ◽  
Active Surveillance ◽  
Low Risk ◽  
Risk Prostate Cancer ◽  
Low Risk Prostate Cancer ◽  
Selection Of Patients ◽  
Selection Of

scholarly journals Spatial distribution of positive cores improves the selection of patients with low-risk prostate cancer as candidates for active surveillance

2013 ◽  
Vol 112 (4) ◽  
pp. E234-E242 ◽  
Author(s):  
Firas Abdollah ◽  
Nazareno Suardi ◽  
Umberto Capitanio ◽  
Andrea Gallina ◽  
Maxine Sun ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Spatial Distribution ◽  
Active Surveillance ◽  
Low Risk ◽  
Risk Prostate Cancer ◽  
Low Risk Prostate Cancer ◽  
Selection Of Patients ◽  
Selection Of

Multidisciplinary Care and Pursuit of Active Surveillance in Low-Risk Prostate Cancer

2012 ◽  
Vol 30 (25) ◽  
pp. 3071-3076 ◽  
Author(s):  
Ayal A. Aizer ◽  
Jonathan J. Paly ◽  
Anthony L. Zietman ◽  
Paul L. Nguyen ◽  
Clair J. Beard ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Active Surveillance ◽  
Tertiary Care ◽  
Multidisciplinary Care ◽  
Low Risk ◽  
Multidisciplinary Clinic ◽  
Risk Prostate Cancer ◽  
Low Risk Prostate Cancer ◽  
Tertiary Care Centers ◽  
Selection Of

Purpose Multidisciplinary clinics offer a unique approach to the management of patients with cancer. Yet, limited data exist to show that such clinics affect management. The purpose of this study was to determine whether consultation at a multidisciplinary clinic is associated with selection of active surveillance in patients with low-risk prostate cancer. Patients and Methods The study comprised 701 men with low-risk prostate cancer managed at three tertiary care centers in Boston, MA in 2009. Patients either obtained consultation at a multidisciplinary prostate cancer clinic, at which they were seen by a combination of urologic, radiation, and medical oncologists in a concurrent setting, or they were seen by individual practitioners in sequential settings. The primary outcome was selection of active surveillance. Results Crude rates of selection of active surveillance in patients seen at a multidisciplinary clinic were double that of patients seen by individual practitioners (43% v 22%), whereas the proportion of men treated with prostatectomy or radiation decreased by approximately 30% (P < .001). On multivariate logistic regression, older age (odds ratio [OR], 1.09; 95% CI, 1.05 to 1.12; P < .001), unmarried status (OR, 1.66; 95% CI, 1.01 to 2.72; P = .04), increased Charlson comorbidity index (OR, 1.37; 95% CI, 1.06 to 1.77; P = .02), fewer positive cores (OR, 0.92; 95% CI, 0.90 to 0.94; P < .001), and consultation at a multidisciplinary clinic (OR, 2.15; 95% CI, 1.13 to 4.10; P = .02) were significantly associated with pursuit of active surveillance. Conclusion Multidisciplinary care is associated with increased selection of active surveillance in men with low-risk prostate cancer. This finding may have an important clinical, social, and economic impact.

Testing the most stringent criteria for selection of candidates for active surveillance in patients with low-risk prostate cancer

2009 ◽  
Vol 105 (11) ◽  
pp. 1548-1552 ◽  
Author(s):  
Nazareno Suardi ◽  
Alberto Briganti ◽  
Andrea Gallina ◽  
Andrea Salonia ◽  
Pierre I. Karakiewicz ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Active Surveillance ◽  
Low Risk ◽  
Risk Prostate Cancer ◽  
Low Risk Prostate Cancer ◽  
Criteria For Selection ◽  
Selection Of

scholarly journals Assessment of PSIM (Prostatic Systemic Inflammatory Markers) Score in Predicting Pathologic Features at Robotic Radical Prostatectomy in Patients with Low-Risk Prostate Cancer Who Met the Inclusion Criteria for Active Surveillance

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 355
Author(s):  
Matteo Ferro ◽  
Gennaro Musi ◽  
Deliu Victor Matei ◽  
Alessandro Francesco Mistretta ◽  
Stefano Luzzago ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Active Surveillance ◽  
Inflammatory Markers ◽  
Low Risk ◽  
Inclusion Criteria ◽  
Robotic Radical Prostatectomy ◽  
Lymphocyte Ratio ◽  
Risk Prostate Cancer ◽  
Low Risk Prostate Cancer

Background: circulating levels of lymphocytes, platelets and neutrophils have been identified as factors related to unfavorable clinical outcome for many solid tumors. The aim of this cohort study is to evaluate and validate the use of the Prostatic Systemic Inflammatory Markers (PSIM) score in predicting and improving the detection of clinically significant prostate cancer (csPCa) in men undergoing robotic radical prostatectomy for low-risk prostate cancer who met the inclusion criteria for active surveillance. Methods: we reviewed the medical records of 260 patients who fulfilled the inclusion criteria for active surveillance. We performed a head-to-head comparison between the histological findings of specimens after radical prostatectomy (RP) and prostate biopsies. The PSIM score was calculated on the basis of positivity according to cutoffs (neutrophil-to-lymphocyte ratio (NLR) 2.0, platelets-to-lymphocyte ratio (PLR) 118 and monocyte-to-lymphocyte-ratio (MLR) 5.0), with 1 point assigned for each value exceeding the specified threshold and then summed, yielding a final score ranging from 0 to 3. Results: median NLR was 2.07, median PLR was 114.83, median MLR was 3.69. Conclusion: we found a significantly increase in the rate of pathological International Society of Urological Pathology (ISUP) ≥ 2 with the increase of PSIM. At the multivariate logistic regression analysis adjusted for age, prostate specific antigen (PSA), PSA density, prostate volume and PSIM, the latter was found the sole independent prognostic variable influencing probability of adverse pathology.

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