Does concurrent postoperative radiotherapy and chemotherapy in head and neck cancer improve patient outcome?

2004 ◽  
Vol 1 (1) ◽  
pp. 14-15 ◽  
Author(s):  
Sue S Yom ◽  
David I Rosenthal
Head & Neck ◽  
2021 ◽  
Author(s):  
John Pang ◽  
Farhoud Faraji ◽  
Erik Risa ◽  
Loren K. Mell ◽  
Jeffrey J. Houlton ◽  
...  

2010 ◽  
Vol 2 (1) ◽  
pp. 43-51
Author(s):  
Vedang Murthy ◽  
Sayan Kundu ◽  
Tanweer Shahid ◽  
Ashwini Budrukkar ◽  
Tejpal Gupta ◽  
...  

Abstract Though early stage head and neck cancers can be cured either by surgery or radiation, patients with locally advanced disease continues to pose a therapeutic challenge. Locoregional failure is the major cause of death in head and neck cancers. As the outcome of locally advanced head and neck cancer is less than promising, a combined modality approach is generally undertaken in this group of patients. The combination of surgery, radiation and more recently, chemotherapy and targeted therapy can improve outcomes in locally advanced head and neck cancer patients. This overview discusses the rationale and role of postoperative radiotherapy (PORT) in advanced head and neck cancers, the radiotherapy technique in brief and methods of enhancing the efficacy of postoperative RT by altering the fractionation schedules and adding chemotherapy and targeted therapy.


Oral Oncology ◽  
2006 ◽  
Vol 42 (2) ◽  
pp. 131-138 ◽  
Author(s):  
Sandrine M.G. van de Pol ◽  
Patricia A.H. Doornaert ◽  
Remco de Bree ◽  
C. René Leemans ◽  
Ben J. Slotman ◽  
...  

1997 ◽  
Vol 33 ◽  
pp. S102-S103 ◽  
Author(s):  
R. Guttenberger ◽  
J. Lutterbach ◽  
A. Roth ◽  
S. Rõser ◽  
R. Schindler ◽  
...  

1993 ◽  
Vol 107 (5) ◽  
pp. 437-440 ◽  
Author(s):  
L. A. Ravasz ◽  
G. J. Hordijk ◽  
P. J. Slootweg ◽  
F. Smit ◽  
I. V. D. Tweel

Eighty consecutive patients with advanced head and neck cancer were treated with combined therapy of radical surgery and post-operative radiotherapy. Indications for post-operative radiotherapy were pathological staging of the primary tumour (pT3 or pT4), poorly differentiated or undifferentiated carcinoma (G3, G4), tumour thickness, tumour invasion in the surrounding tissues with slender tumour strands and solitary tumour cells, perineural spread, lymphangio-invasive tumour growth, multiple positive neck nodes or extranodal spread, and microscopical irradicality of the surgical margins. The contribution for prognosis of these indications for post-operative radiotherapy were retrospectively calculated in an univariate and multivariateanalysis. Of all investigated parameters, the mode of tumour invasion and lymphangio-invasive growth were independent prognostic factors. If these unfavourable prognostic signs are present, post-operative radiotherapy has to be intensified to at least curative doses of 66 Gy or more to the areas at risk.


Sign in / Sign up

Export Citation Format

Share Document