Eleven reasons to control the protein intake of patients with chronic kidney disease

2007 ◽  
Vol 3 (7) ◽  
pp. 383-392 ◽  
Author(s):  
Denis Fouque ◽  
Michel Aparicio
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Protein Intake

scholarly journals Optimal Protein Intake in Pre-Dialysis Chronic Kidney Disease Patients with Sarcopenia: An Overview

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1205
Author(s):  
Yoshitaka Isaka
Keyword(s):  
Chronic Kidney Disease ◽  
High Risk ◽  
Kidney Disease ◽  
Muscle Mass ◽  
Exercise Therapy ◽  
Protein Intake ◽  
Renin Angiotensin System ◽  
Protein Restriction ◽  
Ckd Stage ◽  
End Stage

Multi-factors, such as anorexia, activation of renin-angiotensin system, inflammation, and metabolic acidosis, contribute to malnutrition in chronic kidney disease (CKD) patients. Most of these factors, contributing to the progression of malnutrition, worsen as CKD progresses. Protein restriction, used as a treatment for CKD, can reduce the risk of CKD progression, but may worsen the sarcopenia, a syndrome characterized by a progressive and systemic loss of muscle mass and strength. The concomitant rate of sarcopenia is higher in CKD patients than in the general population. Sarcopenia is also associated with mortality risk in CKD patients. Thus, it is important to determine whether protein restriction should be continued or loosened in CKD patients with sarcopenia. We may prioritize protein restriction in CKD patients with a high risk of end-stage kidney disease (ESKD), classified to stage G4 to G5, but may loosen protein restriction in ESKD-low risk CKD stage G3 patients with proteinuria <0.5 g/day, and rate of eGFR decline <3.0 mL/min/1.73 m2/year. However, the effect of increasing protein intake alone without exercise therapy may be limited in CKD patients with sarcopenia. The combination of exercise therapy and increased protein intake is effective in improving muscle mass and strength in CKD patients with sarcopenia. In the case of loosening protein restriction, it is safe to avoid protein intake of more than 1.5 g/kgBW/day. In CKD patients with high risk in ESKD, 0.8 g/kgBW/day may be a critical point of protein intake.

scholarly journals Influence of dietary protein intake on body composition in chronic kidney disease patients in stages 3–5: A cross-sectional study

Nefrología ◽  
2018 ◽  
Vol 38 (6) ◽  
pp. 647-654
Author(s):  
Guillermina Barril ◽  
Angel Nogueira ◽  
Mar Ruperto López ◽  
Yone Castro ◽  
José Antonio Sánchez-Tomero
Keyword(s):  
Chronic Kidney Disease ◽  
Body Composition ◽  
Kidney Disease ◽  
Dietary Protein ◽  
Protein Intake ◽  
Cross Sectional Study ◽  
Dietary Protein Intake ◽  
Sectional Study ◽  
Cross Sectional

Abstract P100: Dietary Protein Intake and Chronic Kidney Disease in American Population with Hypertension and Diabetes

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Jin-Liern Hong ◽  
Xia Li ◽  
Charles Poole
Keyword(s):  
Chronic Kidney Disease ◽  
High Risk ◽  
Kidney Disease ◽  
Energy Intake ◽  
Dietary Protein ◽  
Protein Intake ◽  
Level Energy ◽  
Dietary Protein Intake ◽  
Prevalence Odds Ratio ◽  
Renal Disease Progression

Background: Dietary protein intake has been associated with renal disease progression in patients with chronic kidney disease (CKD). Little is known about the renal impact of protein intake in persons with hypertension or diabetes who are at high risk for CKD. Objectives: This study aims to evaluate protein intake in relation to CKD in a representative sample of US adults, stratified by hypertension and diabetes. Methods: A cross-sectional study was conducted using data from the US NHANES 2003-2008. Subjects were excluded if they were pregnant, with known weak kidney, or following on special diet. There were 9,284 eligible participants age 20-80 with data from two 24-hour dietary recall questionnaires. Protein intake was adjusted for energy intake and categorized into four evenly spaced groups. CKD was defined as an estimated glomerular filtration rate <60mL/min/1.73m 2 . Logistical regression model was used to estimate the prevalence odds ratio (POR). Analyses were further stratified by hypertension and diabetes. Results: The median protein intake was 77 g/day (interquartile range, 66 to 89 g/day) in the study population, and was 59, 72, 83, and 100 g/day for the lowest to the highest quarter of protein intake, respectively. The prevalence of CKD was 4%. For a 25-g increase in protein intake, the POR was 1.18 (95% CI: 0.93 to 1.50), adjusting for age, sex, race, income adequacy, education level, energy intake, physical activity, cardiovascular disease, diabetes, and hypertension. The adjusted POR comparing the highest and the lowest quarter of protein intake was 1.12 (95%CI: 0.73 to 1.72). The stratified analysis showed the highest quarter is associated with CKD among persons with both hypertension and diabetes ( Table ). No association was found in persons with hypertension only, diabetes only, or neither. Conclusion: We observed a positive association between protein intake and CKD among American adults with both hypertension and diabetes. This finding adds to the concern of dietary protein intake in persons at high-risk for CKD. Table. Adjusted POR of CKD comparing the highest and the lowest quarter of protein intake. Disease Status Hypertension - + Diabetes - 1.05 (0.45 - 2.45) 0.80 (0.44 - 1.47) + 4.63 (0.33 - 65.70) 3.04 (1.13 - 8.19)

scholarly journals MP430DIETARY PROTEIN INTAKE IS ASSOCIATED WITH NUCLEAR FACTOR-KB EXPRESSION IN NON-DIALYSIS CHRONIC KIDNEY DISEASE PATIENTS

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii586-iii587
Author(s):  
Denise Mafra ◽  
Ana Paula Black ◽  
Greicielle Santos da Silva ◽  
Drielly Cristhiny Mendes de Vargas ◽  
Juliana Saraiva dos Anjos
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Protein Intake ◽  
Nuclear Factor ◽  
Nuclear Factor Kb

PP121 DIETARY SALT AND PROTEIN INTAKE FLUCTUATES EVEN UNDER DIETARY EDUCATION IN PATIENTS WITH CHRONIC KIDNEY DISEASE

2010 ◽  
Vol 5 (2) ◽  
pp. 70
Author(s):  
A. Gondo ◽  
T. Okada ◽  
H. Matsumoto ◽  
Y. Nagaoka ◽  
T. Wada ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Protein Intake ◽  
Dietary Salt ◽  
Dietary Education
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