Steroid withdrawal in African American kidney transplant recipients: long-term effects on graft outcomes

2007 ◽  
Vol 3 (7) ◽  
pp. 372-373
Author(s):  
Carlton J Young
Keyword(s):  
African American ◽  
Kidney Transplant ◽  
Steroid Withdrawal ◽  
Transplant Recipients ◽  
Long Term Effects ◽  
Kidney Transplant Recipients

Long-Term Graft Outcomes After Steroid Withdrawal in African American Kidney Transplant Recipients Receiving Sirolimus and Tacrolimus

2007 ◽  
Vol 83 (3) ◽  
pp. 277-281 ◽  
Author(s):  
Donald E. Hricik ◽  
Joshua J. Augustine ◽  
Thomas C. Knauss ◽  
Kenneth A. Bodziak ◽  
Mark Aeder ◽  
...  
Keyword(s):  
African American ◽  
Kidney Transplant ◽  
Steroid Withdrawal ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

scholarly journals Early steroid withdrawal has a positive effect on bone in kidney transplant recipients: a propensity score study with inverse probability-of-treatment weighting

2020 ◽  
Vol 12 ◽  
pp. 1759720X2095335 ◽  
Author(s):  
Benjamin Batteux ◽  
Valérie Gras-Champel ◽  
Mathilde Lando ◽  
François Brazier ◽  
Romuald Mentaverri ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Propensity Score ◽  
Kidney Transplant ◽  
Corticosteroid Therapy ◽  
Steroid Withdrawal ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Inverse Probability ◽  
Positive Effect

Background: Long-term corticosteroid use after kidney transplantation is associated with a decrease in bone mineral density (BMD) and a high fracture risk. We hypothesized that patients with early steroid withdrawal (ESW) would display a gain in BMD in the year following kidney transplantation, when compared with patients on long-term corticosteroid therapy. Methods: In a cohort of kidney transplant recipients, 356 patients were included between 2012 and 2019. Dual-energy X-ray absorptiometry was performed 1 and 12 months after transplantation. The data were analyzed using linear regression with inverse probability-of-treatment weighting (based on a propensity score). Results: At 1 year after transplantation, the gain in BMD was significantly greater in recipients with ESW than in recipients on long-term corticosteroid therapy for the lumbar spine (+0.036 g/cm2, p < 0.001) and the femoral neck (+0.020 g/cm2, p = 0.035). Among patients with ESW, (i) none had osteoporosis, (ii) the percentage with normal BMD increased from 33.3% at month 1 to 54.4% at month 12, and (iii) the percentage with osteopenia fell from 56.2% to 45.6%. In patients undergoing long-term corticosteroid therapy, the fracture incidence was 13.5 per 1000 person-years. None of the patients in the ESW group experienced a fracture. Conclusion: ESW has a positive effect on bone in kidney transplant recipients.

scholarly journals De NovoDonor-Specific HLA Antibody Development and PeripheralCD4+CD25highCells in Kidney Transplant Recipients: A Place for Interaction?

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Josefina Alberu ◽  
Maria Inés Vargas-Rojas ◽  
Luis E. Morales-Buenrostro ◽  
Jose C. Crispin ◽  
Roxana Rodríguez-Romo ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
De Novo ◽  
Late Time ◽  
Transplant Recipients ◽  
Long Term Effects ◽  
Kidney Transplant Recipients ◽  
Inhibitory Mechanisms ◽  
Donor Specific Antibodies ◽  
Late Time Point

The aim of this study was to determine whether the abundance of regulatory T cells (Tregs) (CD4+CD25high) affects thede novodevelopment of anti-HLA donor-specific antibodies (DSAs) in kidney transplant recipients (KTRs).Methods. Unsensitized (PRA ≤ 10%, no DSA) adult primary KTRs who received a living (83%) or deceased (17%) KT in our Institution during 2004/2005 were included. DSA testing was performed monthly, and Tregs were quantified by flow cytometry every 3 months, during the 1st year after KT. All patients received triple drug immunosuppressive therapy (CNI + MMF or AZA + PDN); 83% received anti-CD25.Results. 53 KTRs were included; 32% developed DSA during the 1st year after KT. Significantly lower 7-year graft survival was observed in those who developed DSA. No difference was observed in Treg numbers up to 9 months after KT, between DSA positive and negative. However, at 12 months after KT, DSA-negative patients had significantly higher numbers of Treg.Conclusions. Early development of DSA was not associated to variations in Treg abundance. The differences in Treg numbers observed at the late time point may reflect better immune acceptance of the graft and may be associated to long-term effects. Additional inhibitory mechanisms participating earlier in DSA development after KT deserve to be sought.

Study 2: steroid withdrawal in African American kidney transplant recipients receiving sirolimus and tacrolimus: analysis of renal function beyond 1 year

2003 ◽  
Vol 17 (4) ◽  
pp. S64
Author(s):  
Donald E. Hricik ◽  
Thomas C. Knauss ◽  
Kenneth A. Bodziak ◽  
Kelly Weigel ◽  
Christopher Siegel ◽  
...  
Keyword(s):  
Renal Function ◽  
African American ◽  
Kidney Transplant ◽  
Steroid Withdrawal ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients
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