Long-term outcomes of IL-2R antibody vs antithymocyte globulin for induction therapy in kidney transplantation

2007 ◽  
Vol 3 (3) ◽  
pp. 134-135
Author(s):  
George W Burke ◽  
Gaetano Ciancio
Keyword(s):  
Kidney Transplantation ◽  
Induction Therapy ◽  
Antithymocyte Globulin ◽  
Long Term Outcomes

scholarly journals Combined low-dose everolimus and low-dose tacrolimus after Alemtuzumab induction therapy: a randomized prospective trial in lung transplantation

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Alberto Benazzo ◽  
Ara Cho ◽  
Anna Nechay ◽  
Stefan Schwarz ◽  
Florian Frommlet ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Lung Transplantation ◽  
Kidney Function ◽  
Induction Therapy ◽  
Low Dose ◽  
Prospective Trial ◽  
Control Group ◽  
Long Term Outcomes ◽  
Maintenance Immunosuppression

Abstract Background Long-term outcomes of lung transplantation are severely affected by comorbidities and development of chronic rejection. Among the comorbidities, kidney insufficiency is one of the most frequent and it is mainly caused by the cumulative effect of calcineurin inhibitors (CNIs). Currently, the most used immunosuppression protocols worldwide include induction therapy and a triple-drug maintenance immunosuppression, with one calcineurin inhibitor, one anti-proliferative drug, and steroids. Our center has pioneered the use of alemtuzumab as induction therapy, showing promising results in terms of short- and long-term outcomes. The use of alemtuzumab followed by a low-dose double drug maintenance immunosuppression, in fact, led to better kidney function along with excellent results in terms of acute rejection, chronic lung allograft dysfunction, and survival (Benazzo et al., PLoS One 14(1):e0210443, 2019). The hypothesis driving the proposed clinical trial is that de novo introduction of low-dose everolimus early after transplantation could further improve kidney function via a further reduction of tacrolimus. Based on evidences from kidney transplantation, moreover, alemtuzumab induction therapy followed by a low-dose everolimus and low-dose tacrolimus may have a permissive action on regulatory immune cells thus stimulating allograft acceptance. Methods A randomized prospective clinical trial has been set up to answer the research hypothesis. One hundred ten patients will be randomized in two groups. Treatment group will receive the new maintenance immunosuppression protocol based on low-dose tacrolimus and low-dose everolimus and the control group will receive our standard immunosuppression protocol. Both groups will receive alemtuzumab induction therapy. The primary endpoint of the study is to analyze the effect of the new low-dose immunosuppression protocol on kidney function in terms of eGFR change. The study will have a duration of 24 months from the time of randomization. Immunomodulatory status of the patients will be assessed with flow cytometry and gene expression analysis. Discussion For the first time in the field of lung transplantation, this trial proposes the combined use of significantly reduced tacrolimus and everolimus after alemtuzumab induction. The new protocol may have a twofold advantage: (1) further reduction of nephrotoxic tacrolimus and (2) permissive influence on regulatory cells development with further reduction of rejection episodes. Trial registration EUDRACT Nr 2018-001680-24. Registered on 15 May 2018

A Novel Approach in Combined Liver and Kidney Transplantation With Long-term Outcomes

2017 ◽  
Vol 265 (5) ◽  
pp. 1000-1008 ◽  
Author(s):  
Burcin Ekser ◽  
Richard S. Mangus ◽  
Jonathan A. Fridell ◽  
Chandrashekhar A. Kubal ◽  
Shunji Nagai ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Long Term Outcomes ◽  
Novel Approach ◽  
Liver And Kidney

Kidney transplantation in patients with bladder augmentation: Long term outcomes

2017 ◽  
Vol 16 (3) ◽  
pp. e1982
Author(s):  
K. Yamaçake ◽  
A. Piovesan ◽  
R. Falci ◽  
G. Messi ◽  
H. Kanashiro ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Bladder Augmentation ◽  
Long Term Outcomes
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