Is living-donor kidney volume an independent determinant of post-transplantation graft performance?

2006 ◽  
Vol 2 (10) ◽  
pp. 556-557
Author(s):  
Amgad E El-Agroudy
Keyword(s):  
Living Donor ◽  
Kidney Volume ◽  
Post Transplantation ◽  
Donor Kidney ◽  
Independent Determinant ◽  
Living Donor Kidney

scholarly journals Baseline living‐donor kidney volume and function associate with 1‐year post‐nephrectomy kidney function

2019 ◽  
Vol 33 (3) ◽  
pp. e13485
Author(s):  
Isaac E. Hall ◽  
Akram Shaaban ◽  
Guo Wei ◽  
Magdalena B. Sikora ◽  
Hassan Bourija ◽  
...  
Keyword(s):  
Kidney Function ◽  
Living Donor ◽  
Kidney Volume ◽  
Donor Kidney ◽  
Function Associate ◽  
And Function ◽  
Living Donor Kidney

scholarly journals Effect of Donor and Recipient ABH-Secretor Status on ABO-Incompatible Living Donor Kidney Transplantation

2021 ◽  
Vol 12 ◽  
Author(s):  
Fan Zhang ◽  
Saifu Yin ◽  
Yu Fan ◽  
Turun Song ◽  
Zhongli Huang ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Blood Group ◽  
Graft Rejection ◽  
Living Donor ◽  
Blood Group Antigens ◽  
Post Transplantation ◽  
Donor Kidney ◽  
Secretor Status ◽  
Donor Kidney Transplantation ◽  
Living Donor Kidney

IntroductionABO blood group antigens within grafts are continuously exposed to anti-A/B antibodies in the serum of recipients after ABO-incompatible (ABOi) kidney transplantation and are instrumental in antibody-mediated rejection. Some individuals secrete soluble blood group antigens into body fluids. In this study, we investigated the effect of donor and recipient secretor status on the outcomes of ABOi kidney transplantation.MethodsData of a total of 32 patients with ABOi living donor kidney transplantation were retrospectively collected between 2014 and 2020 in West China Hospital. The genotype and phenotype of both donors and recipients were examined and evaluated with post-transplantation anti-A/B titer changes, graft function, and rejection.ResultsOf the 32 recipients and 32 donors, 23 (71.9%) recipients and 27 (84.4%) donors had secretor genotypes, whereas 9 (28.1%) recipients and 5 (15.6%) donors did not. Anti-A/B titers after ABOi kidney transplantation were not significantly influenced by the secretor status of either donors or recipients. The post-transplantation serum creatinine (Scr) levels and estimated glomerular filtration rate (eGFR) was better in weak- or non-secretor recipients at day 30 (Scr P = 0.047, eGFR P = 0.008), day 90 (Scr P = 0.010, eGFR P = 0.005), and month 9 (eGFR P = 0.008), and recipients from secretor donors had a lower incidence of graft rejection in the first year after ABOi transplantation (P = 0.004).ConclusionsA weak secretor status phenotype was found in both genotypes, i.e., individuals who secreted soluble antigens as well as those who did not. The recipient ABH-secretor status may have an influence on early posttransplant renal function, and the donor ABH-secretor status might affect the incidence of graft rejection.

scholarly journals Clinical Implications for Graft Function of a New Equation Model for the Ratio of Living Donor Kidney Volume to Recipient Body Surface Area

2013 ◽  
Vol 54 (12) ◽  
pp. 870 ◽  
Author(s):  
Chang Ki Lee ◽  
Young Eun Yoon ◽  
Kyung Hwa Choi ◽  
Seung Choul Yang ◽  
Joong Shik Lee ◽  
...  
Keyword(s):  
Surface Area ◽  
Body Surface ◽  
Living Donor ◽  
Graft Function ◽  
Equation Model ◽  
Clinical Implications ◽  
Kidney Volume ◽  
Donor Kidney ◽  
New Equation ◽  
Living Donor Kidney

Living Donor Kidney Volume as a Predictor of Graft Function: Is There a Role for Proteinuria?

2013 ◽  
Vol 45 (1) ◽  
pp. 77-81 ◽  
Author(s):  
H. Akoglu ◽  
T. Yildirim ◽  
G. Eldem ◽  
G. Arik ◽  
R. Yilmaz ◽  
...  
Keyword(s):  
Living Donor ◽  
Graft Function ◽  
Kidney Volume ◽  
Donor Kidney ◽  
Living Donor Kidney

scholarly journals Is Bigger Better? Living Donor Kidney Volume as Measured by the Donor CT Angiogram in Predicting Donor and Recipient eGFR after Living Donor Kidney Transplantation

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Chaudhry Adeel Ebad ◽  
David Brennan ◽  
Julio Chevarria ◽  
Mohammad Bin Hussein ◽  
Donal Sexton ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Kidney Function ◽  
Living Donor ◽  
Volume Measurement ◽  
Kidney Volume ◽  
Donor Kidney ◽  
Living Kidney Donors ◽  
Kidney Recipients ◽  
Ct Angiogram ◽  
Living Donor Kidney

Background. The role of kidney volume measurement in predicting the donor and recipient kidney function is not clear. Methods. We measured kidney volume bilaterally in living kidney donors using CT angiography and assessed the association with the donor remaining kidney and recipient kidney (donated kidney) function at 1 year after kidney transplantation. Donor volume was categorized into tertiles based on lowest, middle, and highest volume. Results. There were 166 living donor and recipient pairs. The mean donor age was 44.8 years (SD ± 10.8), and donor mean BMI was 25.5 (SD ± 2.9). The recipients of living donor kidneys were 64% male and had a mean age of 43.5 years (SD ± 13.3). Six percent of patients experienced an episode of cellular rejection and were maintained on dialysis for a mean of 18 months (13–32) prior to transplant. Kidney volume was divided into tertiles based on lowest, middle, and highest volume. Kidney volume median (range) in tertiles 1, 2, and 3 was 124 (89–135 ml), 155 (136–164 ml), and 184 (165–240 ml) with donor eGFR ml/min (adjusted for body surface area expressed as ml/min/1.73 m2) at the time of donation in each tertile, 109 (93–129), 110 (92–132), and 101 ml/min (84–117). The median (IQR) eGFR in tertiles 1 to 3 in kidney recipients at 1 year after donation was 54 (44–67), 62 (50–75), and 63 ml/min (58–79), respectively. The median (IQR) eGFR in tertiles 1 to 3 in the remaining kidney of donors at 1 year after donation was 59 (53–66), 65 (57–72), and 65 ml/min (56–73), respectively. Conclusion. Bigger kidney volume was associated with better eGFR at 1 year after transplant in the recipient and marginally in the donor remaining kidney.

Lower donated kidney volume is associated with increased risk of lower graft function and acute rejection at 1 year after living donor kidney—a retrospective study

2020 ◽  
Vol 33 (12) ◽  
pp. 1711-1722
Author(s):  
Filipa Silva ◽  
Jorge Malheiro ◽  
Nicole Pestana ◽  
Catarina Ribeiro ◽  
Diogo Nunes‐Carneiro ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Acute Rejection ◽  
Living Donor ◽  
Graft Function ◽  
Kidney Volume ◽  
Donor Kidney ◽  
Increased Risk ◽  
Living Donor Kidney
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