Home fingerprick sampling for immunosuppressant drug monitoring in pediatric renal transplant patients

2006 ◽  
Vol 2 (6) ◽  
pp. 304-305 ◽  
Author(s):  
Philip D Acott
Keyword(s):  
Renal Transplant ◽  
Drug Monitoring ◽  
Immunosuppressant Drug ◽  
Transplant Patients ◽  
Pediatric Renal Transplant ◽  
Renal Transplant Patients

Tracking of blood pressure and its impact on graft function in pediatric renal transplant patients

2007 ◽  
Vol 11 (8) ◽  
pp. 860-867 ◽  
Author(s):  
Douglas M. Silverstein ◽  
Pamela LeBlanc ◽  
James M. Hempe ◽  
Thiagarajan Ramcharan ◽  
J. Philip Boudreaux
Keyword(s):  
Blood Pressure ◽  
Renal Transplant ◽  
Graft Function ◽  
Transplant Patients ◽  
Pediatric Renal Transplant ◽  
Renal Transplant Patients

Clinical Everolimus Experience in Pediatric Renal Transplant Patients

2013 ◽  
Vol 45 (3) ◽  
pp. 913-916 ◽  
Author(s):  
N. Dincel ◽  
I.K. Bulut ◽  
T.Ö. Sezer ◽  
S. Mir ◽  
C. Hoşcoşkun
Keyword(s):  
Renal Transplant ◽  
Transplant Patients ◽  
Pediatric Renal Transplant ◽  
Renal Transplant Patients

Ribavirin therapy of hepatitis E infection may cause hyporegenerative anemia in pediatric renal transplant patients

2018 ◽  
Vol 22 (4) ◽  
pp. e13195 ◽  
Author(s):  
Verena Klämbt ◽  
Marcus Panning ◽  
Maximilian Seidl ◽  
Karsten Häffner ◽  
Martin Pohl
Keyword(s):  
Renal Transplant ◽  
Hepatitis E ◽  
Transplant Patients ◽  
Pediatric Renal Transplant ◽  
Renal Transplant Patients

HPLC-microparticle enzyme immunoassay specific for tacrolimus in whole blood of hepatic and renal transplant patients

1995 ◽  
Vol 41 (9) ◽  
pp. 1292-1296 ◽  
Author(s):  
I Firdaous ◽  
A Hassoun ◽  
J B Otte ◽  
R Reding ◽  
J P Squifflet ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Enzyme Immunoassay ◽  
Drug Monitoring ◽  
Reference Method ◽  
Parent Drug ◽  
Therapeutic Drug ◽  
Blood Concentrations ◽  
Transplant Patients ◽  
Microparticle Enzyme Immunoassay ◽  
Renal Transplant Patients

Abstract Tacrolimus is a relatively new immunosuppressant used in organ transplantation to prevent graft rejection. However, its use is not devoid of side effects, making it important to maintain blood concentrations within therapeutic ranges. Several analytical methods are currently available for routine drug monitoring. However, these methods are based on use of the same monoclonal antibody, which also cross-reacts with some metabolites, resulting in overestimation of some blood concentrations. Even though this antibody appears appropriate for therapeutic drug monitoring, no reference method measures only the parent drug, mainly because of the poor absorptivity of tacrolimus in ultraviolet light. We have developed a method displaying an increased specificity towards the unchanged drug, using conventional equipment available in most clinical laboratories. After chromatographic separation of the blood extract, the tacrolimus fraction is analyzed by an automated microparticle enzyme immunoassay (MEIA) performed on the IMx analyzer (Abbott Labs.). This method is linear from 0 to 40 micrograms/L, yields CVs from 8.5% to 18.2%, and has a detection limit of 5 micrograms/L. Tacrolimus concentrations obtained by HPLC-MEIA in hepatic and renal transplant patients are from 47.5% to 18.8% lower than those obtained by MEIA, according to liver function tests and metabolite accumulation, even though no significant differences were observed between the methods for drug-free blood samples supplemented with known amounts of tacrolimus.

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