Does losartan alter urinary levels of connective tissue growth factor in patients with diabetic nephropathy?

2006 ◽  
Vol 2 (4) ◽  
pp. 192-193
Author(s):  
Josep M Campistol
Keyword(s):  
Diabetic Nephropathy ◽  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth ◽  
Urinary Levels

scholarly journals Connective tissue growth factor in tubulointerstitial injury of diabetic nephropathy

2001 ◽  
Vol 60 (1) ◽  
pp. 96-105 ◽  
Author(s):  
Shinong Wang ◽  
Mark Denichilo ◽  
Carrie Brubaker ◽  
Raimund Hirschberg
Keyword(s):  
Diabetic Nephropathy ◽  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth ◽  
Tubulointerstitial Injury

scholarly journals Elevated Urinary Connective Tissue Growth Factor in Diabetic Nephropathy Is Caused by Local Production and Tubular Dysfunction

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Karin G. F. Gerritsen ◽  
Jan Willem Leeuwis ◽  
Maarten P. Koeners ◽  
Stephan J. L. Bakker ◽  
Willem van Oeveren ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Fractional Excretion ◽  
Tissue Growth ◽  
Tubular Dysfunction ◽  
Diabetic Mice ◽  
Local Production ◽  
Renal Handling

Connective tissue growth factor (CTGF; CCN2) plays a role in the development of diabetic nephropathy (DN). Urinary CTGF (uCTGF) is elevated in DN patients and has been proposed as a biomarker for disease progression, but it is unknown which pathophysiological factors contribute to elevated uCTGF. We studied renal handling of CTGF by infusion of recombinant CTGF in diabetic mice. In addition, uCTGF was measured in type 1 DN patients and compared with glomerular and tubular dysfunction and damage markers. In diabetic mice, uCTGF was increased and fractional excretion (FE) of recombinant CTGF was substantially elevated indicating reduced tubular reabsorption. FE of recombinant CTGF correlated with excretion of endogenous CTGF. CTGF mRNA was mainly localized in glomeruli and medullary tubules. Comparison of FE of endogenous and recombinant CTGF indicated that 60% of uCTGF had a direct renal source, while 40% originated from plasma CTGF. In DN patients, uCTGF was independently associated with markers of proximal and distal tubular dysfunction and damage. In conclusion, uCTGF in DN is elevated as a result of both increased local production and reduced reabsorption due to tubular dysfunction. We submit that uCTGF is a biomarker reflecting both glomerular and tubulointerstitial hallmarks of diabetic kidney disease.

scholarly journals Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice

2008 ◽  
Vol 73 (4) ◽  
pp. 446-455 ◽  
Author(s):  
H. Yokoi ◽  
M. Mukoyama ◽  
K. Mori ◽  
M. Kasahara ◽  
T. Suganami ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth

scholarly journals Reduction of urinary connective tissue growth factor by Losartan in type 1 patients with diabetic nephropathy

2005 ◽  
Vol 67 (6) ◽  
pp. 2325-2329 ◽  
Author(s):  
Steen Andersen ◽  
Frans A. van Nieuwenhoven ◽  
Lise Tarnow ◽  
Peter Rossing ◽  
Kasper Rossing ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth

scholarly journals Role of connective tissue growth factor in the pathogenesis of diabetic nephropathy

2001 ◽  
Vol 359 (1) ◽  
pp. 77 ◽  
Author(s):  
Nadia Abdel WAHAB ◽  
Natalia YEVDOKIMOVA ◽  
Benjamin S. WESTON ◽  
Terry ROBERTS ◽  
Xin Jun LI ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth
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