scholarly journals Regulation of miR-200c/141 expression by intergenic DNA-looping and transcriptional read-through

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Luciana Batista ◽  
Brigitte Bourachot ◽  
Bogdan Mateescu ◽  
Fabien Reyal ◽  
Fatima Mechta-Grigoriou
Keyword(s):  
Dna Looping ◽  
Intergenic Dna

Renaturation and DNA looping promoted by the SV40 large tumour antigen.

1990 ◽  
Vol 9 (9) ◽  
pp. 2937-2943 ◽  
Author(s):  
G. Schiedner ◽  
R. Wessel ◽  
M. Scheffner ◽  
H. Stahl
Keyword(s):  
Dna Looping ◽  
Tumour Antigen ◽  
Large Tumour

scholarly journals TAF7L modulates brown adipose tissue formation

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Haiying Zhou ◽  
Bo Wan ◽  
Ivan Grubisic ◽  
Tommy Kaplan ◽  
Robert Tjian
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Core Promoter ◽  
Uncoupling Protein ◽  
Dna Looping ◽  
Chromatin Interactions ◽  
Brown Adipose ◽  
Important Regulator

Brown adipose tissue (BAT) plays an essential role in metabolic homeostasis by dissipating energy via thermogenesis through uncoupling protein 1 (UCP1). Previously, we reported that the TATA-binding protein associated factor 7L (TAF7L) is an important regulator of white adipose tissue (WAT) differentiation. In this study, we show that TAF7L also serves as a molecular switch between brown fat and muscle lineages in vivo and in vitro. In adipose tissue, TAF7L-containing TFIID complexes associate with PPARγ to mediate DNA looping between distal enhancers and core promoter elements. Our findings suggest that the presence of the tissue-specific TAF7L subunit in TFIID functions to promote long-range chromatin interactions during BAT lineage specification.

scholarly journals Tailoring the activity of restriction endonuclease Ple I by PNA‐induced DNA looping

EMBO Reports ◽  
2002 ◽  
Vol 3 (10) ◽  
pp. 956-961 ◽  
Author(s):  
Ekaterina Protozanova ◽  
Vadim V Demidov ◽  
Viatcheslav Soldatenkov ◽  
Sergey Chasovskikh ◽  
Maxim D Frank‐Kamenetskii
Keyword(s):  
Restriction Endonuclease ◽  
Dna Looping

scholarly journals Measuring Sequence-Dependent DNA Looping Kinetics

2012 ◽  
Vol 102 (3) ◽  
pp. 276a
Author(s):  
Tung Le ◽  
Harold Kim
Keyword(s):  
Dna Looping ◽  
Sequence Dependent ◽  
Measuring Sequence

Gene insulation. Part II: natural strategies in vertebrates

2010 ◽  
Vol 88 (6) ◽  
pp. 885-898 ◽  
Author(s):  
Michèle Amouyal
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Protein Interactions ◽  
Dna Looping ◽  
Chromatin Domain ◽  
Trna Genes ◽  
Binding Factor ◽  
Genomic Environment ◽  
Nuclear Structures ◽  
Definition Of

The way a gene is insulated from its genomic environment in vertebrates is not basically different from what is observed in yeast and Drosophila (preceding article in this issue). If the formation of a looped chromatin domain, whether generated by attachment to the nuclear matrix or not, has become a classic way to confine an enhancer to a specific genomic domain and to coordinate, sequentially or simultaneously, gene expression in a given program, its role has been extended to new networks of genes or regulators within the same gene. A wider definition of the bases of the chromatin loops (nonchromosomal nuclear structures or genomic interacting elements) is also available. However, whereas insulation in Drosophila is due to a variety of proteins, in vertebrates insulators are still practically limited to CTCF (the CCCTC-binding factor), which appears in all cases to be the linchpin of an architecture that structures the assembly of DNA–protein interactions for gene regulation. As in yeast and Drosophila, the economy of means is the rule and the same unexpected diversion of known transcription elements (active or poised RNA polymerases, TFIIIC elements out of tRNA genes, permanent histone replacement) is observed, with variants peculiar to CTCF. Thus, besides structuring DNA looping, CTCF is a barrier to DNA methylation or interferes with all sorts of transcription processes, such as that generating heterochromatin.

scholarly journals The Effect of Nonspecific Binding of Lambda Repressor on DNA Looping Dynamics

2012 ◽  
Vol 103 (8) ◽  
pp. 1753-1761 ◽  
Author(s):  
Carlo Manzo ◽  
Chiara Zurla ◽  
David D. Dunlap ◽  
Laura Finzi
Keyword(s):  
Dna Looping ◽  
Nonspecific Binding ◽  
Lambda Repressor
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