scholarly journals Correction: Corrigendum: BMP signalling differentially regulates distinct haematopoietic stem cell types

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Mihaela Crisan ◽  
Parham Solaimani Kartalaei ◽  
Chris S. Vink ◽  
Tomoko Yamada-Inagawa ◽  
Karine Bollerot ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Types ◽  
Haematopoietic Stem Cell ◽  
Bmp Signalling

scholarly journals BMP signalling differentially regulates distinct haematopoietic stem cell types

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Mihaela Crisan ◽  
Parham Solaimani Kartalaei ◽  
Chris S. Vink ◽  
Tomoko Yamada-Inagawa ◽  
Karine Bollerot ◽  
...  
Keyword(s):  
Stem Cell ◽  
Developmental Stages ◽  
Fetal Liver ◽  
Cell Lineage ◽  
Cell Types ◽  
Haematopoietic Stem Cell ◽  
Control Mechanisms ◽  
Molecular Control ◽  
Bmp Signalling ◽  
Insight Into

Abstract Adult haematopoiesis is the outcome of distinct haematopoietic stem cell (HSC) subtypes with self-renewable repopulating ability, but with different haematopoietic cell lineage outputs. The molecular basis for this heterogeneity is largely unknown. BMP signalling regulates HSCs as they are first generated in the aorta-gonad-mesonephros region, but at later developmental stages, its role in HSCs is controversial. Here we show that HSCs in murine fetal liver and the bone marrow are of two types that can be prospectively isolated—BMP activated and non-BMP activated. Clonal transplantation demonstrates that they have distinct haematopoietic lineage outputs. Moreover, the two HSC types differ in intrinsic genetic programs, thus supporting a role for the BMP signalling axis in the regulation of HSC heterogeneity and lineage output. Our findings provide insight into the molecular control mechanisms that define HSC types and have important implications for reprogramming cells to HSC fate and treatments targeting distinct HSC types.

scholarly journals The Haematopoietic Stem Cell Niche: New Insights into the Mechanisms Regulating Haematopoietic Stem Cell Behaviour

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Andrew J. Lilly ◽  
William E. Johnson ◽  
Christopher M. Bunce
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Stem Cell Niche ◽  
Cell Types ◽  
Haematopoietic Stem Cell ◽  
Cell Behaviour ◽  
Ongoing Research ◽  
Hsc Niche ◽  
Numerous Cell ◽  
Cell Niche

The concept of the haematopoietic stem cell (HSC) niche was formulated by Schofield in the 1970s, as a region within the bone marrow containing functional cell types that can maintain HSC potency throughout life. Since then, ongoing research has identified numerous cell types and a plethora of signals that not only maintain HSCs, but also dictate their behaviour with respect to homeostatic requirements and exogenous stresses. It has been proposed that there are endosteal and vascular niches within the bone marrow, which are thought to regulate different HSC populations. However, recent data depicts a more complicated picture, with functional crosstalk between cells in these two regions. In this review, recent research into the endosteal/vascular cell types and signals regulating HSC behaviour are considered, together with the possibility of a single subcompartmentalised niche.

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