scholarly journals EphB4 forward signalling regulates lymphatic valve development

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Gu Zhang ◽  
John Brady ◽  
Wei-Ching Liang ◽  
Yan Wu ◽  
Mark Henkemeyer ◽  
...  
Keyword(s):  
Valve Development ◽  
Lymphatic Valve

Fsp1 cardiac embryonic expression delineates atrioventricular endocardial cushion, coronary venous and lymphatic valve development

2020 ◽  
Vol 238 (2) ◽  
pp. 508-514
Author(s):  
Sara Cano‐Ballesteros ◽  
Paul Palmquist‐Gomes ◽  
Ernesto Marín‐Sedeño ◽  
Juan Antonio Guadix ◽  
José María Pérez‐Pomares
Keyword(s):  
Endocardial Cushion ◽  
Valve Development ◽  
Lymphatic Valve

scholarly journals Defective lymphatic valve development and chylothorax in mice with a lymphatic-specific deletion of Connexin43

2017 ◽  
Vol 421 (2) ◽  
pp. 204-218 ◽  
Author(s):  
Stephanie J. Munger ◽  
Michael J. Davis ◽  
Alexander M. Simon
Keyword(s):  
Valve Development ◽  
Lymphatic Valve ◽  
Specific Deletion

scholarly journals Connexin37 and Connexin43 deficiencies in mice disrupt lymphatic valve development and result in lymphatic disorders including lymphedema and chylothorax

2011 ◽  
Vol 354 (2) ◽  
pp. 253-266 ◽  
Author(s):  
John D. Kanady ◽  
Michael T. Dellinger ◽  
Stephanie J. Munger ◽  
Marlys H. Witte ◽  
Alexander M. Simon
Keyword(s):  
Valve Development ◽  
Lymphatic Valve

scholarly journals Piezo1 incorporates mechanical force signals into the genetic program that governs lymphatic valve development and maintenance

JCI Insight ◽  
2019 ◽  
Vol 4 (5) ◽  
Author(s):  
Dongwon Choi ◽  
Eunkyung Park ◽  
Eunson Jung ◽  
Boksik Cha ◽  
Somin Lee ◽  
...  
Keyword(s):  
Mechanical Force ◽  
Genetic Program ◽  
Valve Development ◽  
Lymphatic Valve

scholarly journals Primary and secondary lymphatic valve development: Molecular, functional and mechanical insights

2014 ◽  
Vol 96 ◽  
pp. 38-45 ◽  
Author(s):  
Eleni Bazigou ◽  
John T. Wilson ◽  
James E. Moore
Keyword(s):  
Valve Development ◽  
Lymphatic Valve

scholarly journals PDGFRα: Expression and Function during Mitral Valve Morphogenesis

2021 ◽  
Vol 8 (3) ◽  
pp. 28
Author(s):  
Kelsey Moore ◽  
Diana Fulmer ◽  
Lilong Guo ◽  
Natalie Koren ◽  
Janiece Glover ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Primary Cilia ◽  
Growth Factor Receptor ◽  
Akt Phosphorylation ◽  
Valve Development ◽  
Biochemical Assays ◽  
Factor Receptor Alpha ◽  
Mesenchymal Transformation ◽  
And Function

Mitral valve prolapse (MVP) is a common form of valve disease and can lead to serious secondary complications. The recent identification of MVP causal mutations in primary cilia-related genes has prompted the investigation of cilia-mediated mechanisms of disease inception. Here, we investigate the role of platelet-derived growth factor receptor-alpha (PDGFRα), a receptor known to be present on the primary cilium, during valve development using genetically modified mice, biochemical assays, and high-resolution microscopy. While PDGFRα is expressed throughout the ciliated valve interstitium early in development, its expression becomes restricted on the valve endocardium by birth and through adulthood. Conditional ablation of Pdgfra with Nfatc1-enhancer Cre led to significantly enlarged and hypercellular anterior leaflets with disrupted endothelial adhesions, activated ERK1/2, and a dysregulated extracellular matrix. In vitro culture experiments confirmed a role in suppressing ERK1/2 activation while promoting AKT phosphorylation. These data suggest that PDGFRα functions to suppress mesenchymal transformation and disease phenotypes by stabilizing the valve endocardium through an AKT/ERK pathway.

BMDO SBIR multi-function valve development testing

1998 ◽  
Author(s):  
D. Schappell ◽  
C. Geangu ◽  
S. Grisnik
Keyword(s):  
Valve Development
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