scholarly journals PW1/Peg3 expression regulates key properties that determine mesoangioblast stem cell competence

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Chiara Bonfanti ◽  
Giuliana Rossi ◽  
Francesco Saverio Tedesco ◽  
Monica Giannotta ◽  
Sara Benedetti ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Competence

Differentiation-related changes in mitochondrial properties as indicators of stem cell competence

2006 ◽  
Vol 208 (1) ◽  
pp. 149-153 ◽  
Author(s):  
Thomas Lonergan ◽  
Carol Brenner ◽  
Barry Bavister
Keyword(s):  
Stem Cell ◽  
Cell Competence

scholarly journals A Protodermal miR394 Signal Defines a Region of Stem Cell Competence in the Arabidopsis Shoot Meristem

2013 ◽  
Vol 24 (2) ◽  
pp. 125-132 ◽  
Author(s):  
Steffen Knauer ◽  
Anna L. Holt ◽  
Ignacio Rubio-Somoza ◽  
Elise J. Tucker ◽  
Annika Hinze ◽  
...  
Keyword(s):  
Stem Cell ◽  
Shoot Meristem ◽  
Cell Competence

scholarly journals CCNG1 oncogene: a novel biomarker for cancer therapy /gene therapy

2021 ◽  
Vol 5 (4) ◽  
pp. 01-09
Author(s):  
Erlinda M. Gordon ◽  
Joshua R. Ravicz ◽  
Sant P. Chawla ◽  
Christopher W. Szeto ◽  
Sant P. Chawla ◽  
...  
Keyword(s):  
Stem Cell ◽  
Differential Expression ◽  
B Cell Lymphoma ◽  
Inhibitor Therapy ◽  
Nerve Sheath Tumor ◽  
Ki 67 ◽  
Primary Tumors ◽  
Cyclin G1 ◽  
Potential Biomarker ◽  
Cell Competence

Background: Metastatic cancer is associated with an invariably fatal outcome. However, DeltaRex-G, a tumor-targeted retrovector encoding a gene-edited dominant-negative CCNG1 inhibitor gene, has induced long term (>10 years) survival of patients with chemo-resistant metastatic pancreatic adenocarcinoma, malignant peripheral nerve sheath tumor, osteosarcoma, B-cell lymphoma, and breast carcinoma. Objective: To evaluate the level of CCNG1 expression in tumors as a potential biomarker for CCNG1 (Cyclin G1-blocking) inhibitor therapy. Methods: CCNG1 RNA expression levels that were previously measured as part of whole genome molecular profiling of tumors (TCGA, N=9161), adjacent “tissues” (TCGA, N=678) and GTEx normal tissues (N=7187) across 22 organ sites were analyzed. Differential expression of CCNG1 and Ki-67 in primary (N= 9161) vs metastatic (N= 393) tumors were also compared in primary (N=103) vs. metastatic (N=367) skin cancers (i.e., melanoma). Statistical Analysis: To detect systematically differential expression of CCNG1 and Ki-67 expression between populations (e.g. tumor vs. normal), unpaired Student's t-tests were performed. Results: Enhanced CCNG1 RNA and Cyclin G1 protein expression were noted in tumors compared to normal analogous counterparts, and CCNG1 expression correlated significantly with that of Ki-67. Moreover, CCNG1 expression tended to be higher than that of Ki-67 in metastatic vs primary tumors. Conclusions: Taken together with the emerging Cyclin G1 / Cdk / Myc / Mdm2 / p53 Axis governing Cancer Stem Cell Competence, this supportive data indicates: (1) CCNG1 expression is frequently enhanced in tumors when compared to their normal analogous counterparts, (2) CCNG1 and Ki-67 expressions are higher in metastatic vs primary tumors, (3) CCNG1 expression is significantly correlated with that of Ki-67, and (4) CCNG1 may actually be a stronger prognostic marker of stem cell competence, chemo-refractoriness, and EMT/metastasis than Ki-67. Phase 2 studies are planned to identify patients most likely to respond favorably to CCNG1 inhibitor therapy.

scholarly journals Evaluation of porcine stem cell competence for somatic cell nuclear transfer and production of cloned animals

2017 ◽  
Vol 178 ◽  
pp. 40-49 ◽  
Author(s):  
Jan O. Secher ◽  
Ying Liu ◽  
Stoyan Petkov ◽  
Yonglun Luo ◽  
Dong Li ◽  
...  
Keyword(s):  
Stem Cell ◽  
Somatic Cell ◽  
Somatic Cell Nuclear Transfer ◽  
Nuclear Transfer ◽  
Cell Competence

Author response for "Inhibition of neural stem cell aging through the transient induction of reprogramming factors"

2020 ◽  
Author(s):  
Min Ji Han ◽  
Won Ji Lee ◽  
Joonhyuk Choi ◽  
Yean Ju Hong ◽  
Sang Jun Uhm ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Author Response ◽  
Cell Aging ◽  
Stem Cell Aging ◽  
Reprogramming Factors
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