Changing the peptide specificity of a human T-cell receptor by directed evolution

Sheena N. Smith; Yuhang Wang; Javier L. Baylon; Nishant K. Singh; Brian M. Baker; Emad Tajkhorshid; David M. Kranz

doi:10.1038/ncomms6223

Changing the peptide specificity of a human T-cell receptor by directed evolution

Nature Communications ◽

10.1038/ncomms6223 ◽

2014 ◽

Vol 5 (1) ◽

Cited By ~ 14

Author(s):

Sheena N. Smith ◽

Yuhang Wang ◽

Javier L. Baylon ◽

Nishant K. Singh ◽

Brian M. Baker ◽

...

Keyword(s):

T Cell ◽

Directed Evolution ◽

T Cell Receptor ◽

Cell Receptor ◽

Peptide Specificity ◽

Human T Cell

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Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity

Protein Science ◽

10.1110/ps.051936406 ◽

2006 ◽

Vol 15 (4) ◽

pp. 710-721 ◽

Cited By ~ 73

Author(s):

S. M. Dunn

Keyword(s):

T Cell ◽

Phage Display ◽

Directed Evolution ◽

T Cell Receptor ◽

Cell Receptor ◽

Cross Reactivity ◽

Human T Cell

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Author response for "Human T‐cell receptor V gene segment of alpha and beta families: A revised primer design strategy"

10.1002/eji.201747328/v4/response1 ◽

2018 ◽

Author(s):

Angela Chiew Wen Ch'ng ◽

Soo Khim Chan ◽

Joshua Ignatius ◽

Theam Soon Lim

Keyword(s):

T Cell ◽

T Cell Receptor ◽

Gene Segment ◽

Design Strategy ◽

Cell Receptor ◽

Primer Design ◽

Author Response ◽

Human T Cell ◽

V Gene

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Author response for "Human T‐cell receptor V gene segment of alpha and beta families: A revised primer design strategy"

10.1002/eji.201747328/v2/response1 ◽

2018 ◽

Author(s):

Angela Chiew Wen Ch'ng ◽

Soo Khim Chan ◽

Joshua Ignatius ◽

Theam Soon Lim

Keyword(s):

T Cell ◽

T Cell Receptor ◽

Gene Segment ◽

Design Strategy ◽

Cell Receptor ◽

Primer Design ◽

Author Response ◽

Human T Cell ◽

V Gene

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Decision letter for "Human T‐cell receptor V gene segment of alpha and beta families: A revised primer design strategy"

10.1002/eji.201747328/v2/decision1 ◽

2018 ◽

Keyword(s):

T Cell ◽

T Cell Receptor ◽

Gene Segment ◽

Design Strategy ◽

Cell Receptor ◽

Primer Design ◽

Human T Cell ◽

V Gene

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Review for "Human T‐cell receptor V gene segment of alpha and beta families: A revised primer design strategy"

10.1002/eji.201747328/v1/review2 ◽

2017 ◽

Keyword(s):

T Cell ◽

T Cell Receptor ◽

Gene Segment ◽

Design Strategy ◽

Cell Receptor ◽

Primer Design ◽

Human T Cell ◽

V Gene

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Faculty Opinions recommendation of A structural basis for immunodominant human T cell receptor recognition.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1014534.193820 ◽

2003 ◽

Author(s):

Pedro Romero

Keyword(s):

T Cell ◽

T Cell Receptor ◽

Cell Receptor ◽

Structural Basis ◽

Human T Cell ◽

Receptor Recognition

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Faculty Opinions recommendation of Degenerate self-reactive human T-cell receptor causes spontaneous autoimmune disease in mice.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1020983.240591 ◽

2004 ◽

Author(s):

Torben Lund

Keyword(s):

T Cell ◽

Autoimmune Disease ◽

T Cell Receptor ◽

Cell Receptor ◽

Human T Cell

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Ovalbumin Antigen-Specific Activation of Human T Cell Receptor Closely Resembles Soluble Antibody Stimulation as Revealed by BOOST Phosphotyrosine Proteomics

Journal of Proteome Research ◽

10.1021/acs.jproteome.1c00239 ◽

2021 ◽

Author(s):

Xien Yu Chua ◽

Arthur Salomon

Keyword(s):

T Cell ◽

T Cell Receptor ◽

Cell Receptor ◽

Human T Cell

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Identification of an ionomycin/cyclosporin A-responsive element within the human T cell receptor gamma enhancer

European Journal of Immunology ◽

10.1002/eji.1830251223 ◽

1995 ◽

Vol 25 (12) ◽

pp. 3356-3364 ◽

Cited By ~ 3

Author(s):

Thore Hettmann ◽

Amos Cohen

Keyword(s):

T Cell ◽

Cyclosporin A ◽

T Cell Receptor ◽

Cell Receptor ◽

Human T Cell ◽

Responsive Element

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T-cell receptor Vβ5 usage defines reactivity to a human T-cell receptor monoclonal antibody

Immunogenetics ◽

10.1007/bf02421201 ◽

1989 ◽

Vol 30 (3) ◽

pp. 162-168 ◽

Cited By ~ 4

Author(s):

Maria Lipoldova ◽

Arthur W. Boylston ◽

Hans Yssel ◽

Michael J. Owen

Keyword(s):

Monoclonal Antibody ◽

T Cell ◽

T Cell Receptor ◽

Cell Receptor ◽

Human T Cell ◽

Receptor Monoclonal Antibody

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