scholarly journals Spatial control of the GEN1 Holliday junction resolvase ensures genome stability

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Ying Wai Chan ◽  
Stephen C. West
Keyword(s):  
Genome Stability ◽  
Holliday Junction ◽  
Spatial Control ◽  
Holliday Junction Resolvase

scholarly journals The Cdk/Cdc14 Module Controls Activation of the Yen1 Holliday Junction Resolvase to Promote Genome Stability

2014 ◽  
Vol 54 (1) ◽  
pp. 80-93 ◽  
Author(s):  
Christie L. Eissler ◽  
Gerard Mazón ◽  
Brendan L. Powers ◽  
Sergey N. Savinov ◽  
Lorraine S. Symington ◽  
...  
Keyword(s):  
Genome Stability ◽  
Holliday Junction ◽  
Holliday Junction Resolvase

A Test of the Double-Strand Break Repair Model for Meiotic Recombination in Saccharomyces cerevisiae

Genetics ◽  
1996 ◽  
Vol 144 (1) ◽  
pp. 27-41 ◽  
Author(s):  
Larry A Gilbertson ◽  
Franklin W Stahl
Keyword(s):  
Meiotic Recombination ◽  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Holliday Junction ◽  
Single Event ◽  
Heteroduplex Dna ◽  
Holliday Junction Resolvase ◽  
Break Repair ◽  
Two Sides

Abstract We tested predictions of the double-strand break repair (DSBR) model for meiotic recombination by examining the segregation patterns of small palindromic insertions, which frequently escape mismatch repair when in heteroduplex DNA. The palindromes flanked a well characterized DSB site at the ARC4 locus. The “canonical” DSBR model, in which only 5′ ends are degraded and resolution of the four-stranded intermediate is by Holliday junction resolvase, predicts that hDNA will frequently occur on both participating chromatids in a single event. Tetrads reflecting this configuration of hDNA were rare. In addition, a class of tetrads not predicted by the canonical DSBR model was identified. This class represented events that produced hDNA in a “trans” configuration, on opposite strands of the same duplex on the two sides of the DSB site. Whereas most classes of convertant tetrads had typical frequencies of associated crossovers, tetrads with trans hDNA were parental for flanking markers. Modified versions of the DSBR model, including one that uses a topoisomerase to resolve the canonical DSBR intermediate, are supported by these data.

scholarly journals Mus81-Eme1 Are Essential Components of a Holliday Junction Resolvase

Cell ◽  
2001 ◽  
Vol 107 (4) ◽  
pp. 537-548 ◽  
Author(s):  
Michael N. Boddy ◽  
Pierre-Henri L. Gaillard ◽  
W.Hayes McDonald ◽  
Paul Shanahan ◽  
John R. Yates ◽  
...  
Keyword(s):  
Holliday Junction ◽  
Essential Components ◽  
Holliday Junction Resolvase
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