A female gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite

Phuong N. Tran; Simon H. J. Brown; Todd W. Mitchell; Kai Matuschewski; Paul J. McMillan; Kiaran Kirk; Matthew W. A. Dixon; Alexander G. Maier

doi:10.1038/ncomms5773

A female gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite

Nature Communications ◽

10.1038/ncomms5773 ◽

2014 ◽

Vol 5 (1) ◽

Cited By ~ 22

Author(s):

Phuong N. Tran ◽

Simon H. J. Brown ◽

Todd W. Mitchell ◽

Kai Matuschewski ◽

Paul J. McMillan ◽

...

Keyword(s):

Lipid Metabolism ◽

Abc Transporter ◽

Malaria Parasite ◽

Female Gametocyte

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ABCA7, A novel ABC transporter potentially involved in Macrophage Lipid Metabolism

Atherosclerosis ◽

10.1016/s0021-9150(00)81066-7 ◽

2000 ◽

Vol 151 (1) ◽

pp. 235

Author(s):

W.E. Kaminski ◽

J. Klucken ◽

G. Schmitz

Keyword(s):

Lipid Metabolism ◽

Abc Transporter

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The role of osmiophilic bodies and Pfg377 expression in female gametocyte emergence and mosquito infectivity in the human malaria parasite Plasmodium falciparum

Molecular Microbiology ◽

10.1111/j.1365-2958.2007.06039.x ◽

2007 ◽

Vol 67 (2) ◽

pp. 278-290 ◽

Cited By ~ 61

Author(s):

Tania F. De Koning-Ward ◽

Anna Olivieri ◽

Lucia Bertuccini ◽

Andrew Hood ◽

Francesco Silvestrini ◽

...

Keyword(s):

Plasmodium Falciparum ◽

Malaria Parasite ◽

Human Malaria Parasite ◽

Human Malaria ◽

Female Gametocyte ◽

Parasite Plasmodium ◽

Parasite Plasmodium Falciparum

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The Plasmodium falciparum protein PfMRP1 functions as an influx ABC transporter

10.21203/rs.3.rs-1210682/v1 ◽

2022 ◽

Author(s):

Miguel Silva ◽

Carla Calçada ◽

Nuno Osório ◽

Vitória Baptista ◽

Vandana Thathy ◽

...

Keyword(s):

Phylogenetic Analysis ◽

Plasmodium Falciparum ◽

Plasma Membrane ◽

Abc Transporter ◽

Abc Transporters ◽

Malaria Parasite ◽

Drug Transport ◽

Parasite Species ◽

Antimalarial Activity ◽

Falciparum Protein

Abstract Adenosine triphosphate (ATP)-binding cassette (ABC) transporters play an important role in mediating solute or drug transport across cellular membranes. Although this class of transporters has been well characterized in diverse organisms little is known about the physiological roles in Plasmodium falciparum, the deadliest malaria parasite species. We studied the Plasmodium falciparum Multidrug Resistance-associated Protein 1 (PfMRP1; PF3D7_0112200), an ABC transporter localized to the parasite plasma membrane, generating genetic disrupted parasites. We demonstrate that parasites with disrupted pfmrp1 are resistant to folate analogs, methotrexate and aminopterin, with antimalarial activity. This phenotype occurs due to reduction in compound accumulation in the parasite cytoplasm. Phylogenetic analysis supports pfmrp1 being distantly related to ABC transporters in other eukaryotes, suggesting an unusual function. We propose that PfMRP1 can act as a solute importer, a function not previously observed in this organism.

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P93W4-3 Cell proliferation and lipid metabolism in intraerythrocytic malaria parasite, Plasmodium falciparum

Medical Entomology and Zoology ◽

10.7601/mez.52.101_1 ◽

2001 ◽

Vol 52 (Supplement) ◽

pp. 101

Author(s):

Toshihide MITAMURA ◽

Pamela MAGISTRADO ◽

Nirianne PALACPAC ◽

Toshihiro HORII

Keyword(s):

Cell Proliferation ◽

Plasmodium Falciparum ◽

Lipid Metabolism ◽

Malaria Parasite ◽

Parasite Plasmodium ◽

Parasite Plasmodium Falciparum

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A Cytochemical Study of Glucose-6-Phosphatase (G-6-PASE) in Cells Participating in Atherogenesis of Rabbit Aorta

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100115924 ◽

1975 ◽

Vol 33 ◽

pp. 460-461

Author(s):

Sidney D. Kobernick ◽

Edna A. Elfont ◽

Neddra L. Brooks

Keyword(s):

Lipid Metabolism ◽

New Zealand ◽

Aortic Wall ◽

Rabbit Aorta ◽

Plaque Formation ◽

Metabolic Changes ◽

Atherosclerotic Plaques ◽

Cytochemical Study ◽

Cellular Alteration ◽

New Zealand White Rabbits

This cytochemical study was designed to investigate early metabolic changes in the aortic wall that might lead to or accompany development of atherosclerotic plaques in rabbits. The hypothesis that the primary cellular alteration leading to plaque formation might be due to changes in either carbohydrate or lipid metabolism led to histochemical studies that showed elevation of G-6-Pase in atherosclerotic plaques of rabbit aorta. This observation initiated the present investigation to determine how early in plaque formation and in which cells this change could be observed.Male New Zealand white rabbits of approximately 2000 kg consumed normal diets or diets containing 0.25 or 1.0 gm of cholesterol per day for 10, 50 and 90 days. Aortas were injected jin situ with glutaraldehyde fixative and dissected out. The plaques were identified, isolated, minced and fixed for not more than 10 minutes. Incubation and postfixation proceeded as described by Leskes and co-workers.

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